{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:02Z","timestamp":1787028662525,"version":"build-2736575974"},"reference-count":29,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["20K19410"],"award-info":[{"award-number":["20K19410"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Post-Intensive Care Syndrome (PICS), which includes Intensive Care Unit-Acquired Weakness (ICU-AW), can lead to lasting functional impairments even after patients are discharged from the hospital. Early mobilization is a key strategy for preventing ICU-AW, a major contributor to PICS. The primary objective of this study is to assess the impact of early mobilization on ICU-AW in critically ill sepsis patients, while also evaluating the feasibility of a larger, multicenter study through comparison with previous data. Methods: This multicenter observational study, conducted in four hospitals in Nagano Prefecture, Japan, from April 2020 to March 2023, included sepsis patients admitted to the ICU or emergency departments. Patients were classified into ICU-AW and non-ICU-AW groups based on admission data. Background factors and discharge outcomes (complications, ADL, physical function) were assessed. Logistic regression analysis was performed to evaluate the relationship between early mobilization and ICU-AW incidence, with a subgroup analysis on the impact of a dedicated team or physiotherapist. Results: A total of 154 sepsis patients were enrolled, with 76 (49.4%) diagnosed with ICU-AW at discharge. The most common infection source in ICU-AW patients was the urinary tract (31%). Early mobilization (\u22653 days) significantly reduced ICU-AW incidence, with adjusted odds ratios of 3.73 (95% CI = 1.79\u20137.77) for treatment details and 2.93 (95% CI = 1.22\u20137.08) for patient factors. However, the presence of a dedicated team or physiotherapist did not significantly affect ICU-AW incidence, with adjusted odds ratios of 0.50 (95% CI = 0.24\u201310.6) and 0.99 (95% CI = 0.40\u20132.47), respectively. Conclusions: Early mobilization effectively reduced ICU-AW incidence in sepsis patients, though a dedicated team or physiotherapist had no significant impact. Urinary tract infections were the most common infection source in ICU-AW patients. Early mobilization during dialysis for acute kidney injury shows promising potential and warrants further promotion.<\/jats:p>","DOI":"10.3390\/jcm14165904","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T15:19:02Z","timestamp":1755789542000},"page":"5904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Impact of Early Mobilization on the Incidence of Intensive Care Unit-Acquired Weakness in Patients with Sepsis in the Critical Care\u2014The Shinshu Multicenter Prospective Cohort Study (EROSCCS Study)"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-4654","authenticated-orcid":false,"given":"Yasunari","family":"Sakai","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Shinshu University Hospital, Nagano 390-8621, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Taniuchi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Center, Aizawa Hospital, Nagano 390-0814, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Karasawa","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Ina Central Hospital, Nagano 396-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Saku Central Hospital Advanced Care Center, Nagano 385-0051, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Saku Central Hospital Advanced Care Center, Nagano 385-0051, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Shinshu University Hospital, Nagano 390-8621, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-486X","authenticated-orcid":false,"given":"Hiroshi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Advanced Emergency Critical Care Center, Shinshu University Hospital, Nagano 390-0802, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Shinshu University Hospital, Nagano 390-8621, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1007\/s00134-007-0772-2","article-title":"Neuromuscular dysfunction acquired in critical illness: A systematic review","volume":"33","author":"Stevens","year":"2007","journal-title":"Intensive Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1600-0404.2008.00996.x","article-title":"Predisposing factors for critical illness polyneuro myopathy in a multidisciplinary intensive care unit","volume":"118","author":"Nanas","year":"2008","journal-title":"Acta Neurol Scand."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1164\/rccm.201004-0670OC","article-title":"Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans","volume":"183","author":"Jaber","year":"2011","journal-title":"Am. 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