{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:01:22Z","timestamp":1787068882206,"version":"build-2736575974"},"reference-count":23,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The aim of this study was to evaluate the cervical regeneration process following monopolar electrosurgical conization (MESC), using a multimodal approach including ultrasonographic, cytologic, colposcopic, and histologic assessments, and to determine the relationship between the extent of excision and the capacity for cervical tissue regeneration. Methods: This prospective observational study included 28 patients who underwent MESC due to abnormal cervical cytology or biopsy-confirmed cervical intraepithelial neoplasia. Preoperative, postoperative one month and six month cervical measurements were obtained using two-dimensional transvaginal ultrasonography. Monthly colposcopic evaluations were conducted, cervical biopsies were taken at the third month, and a cytological assessment was performed at the sixth month. Cervical volume and length regeneration were calculated and analyzed in relation to the dimensions of the excised cone. Regeneration percentages and their correlations with excised tissue dimensions were evaluated using paired t-tests and Pearson correlation analysis. Results: Mean cervical volume and length regeneration rates at six months were 84.61% \u00b1 5.64 and 86.36% \u00b1 3.33, respectively. The transformation zone was histologically visible in 32.1% of patients at three months and cytologically in 75.9% at six months. An inverse correlation was observed between both cone volume and length and cervical regeneration (p &lt; 0.005). Patients with larger preoperative cervical dimensions exhibited a higher regenerative capacity. Positive surgical margins were found in only one patient (3.4%), and no high-grade cytologic abnormalities were noted at follow-up. Conclusions: MESC may enable substantial cervical regeneration within six months. Larger excisions impair healing and delay transformation zone reformation, which may inform the optimal timing for initiating gynecological and colposcopic examinations, as well as for performing cervical interventions when indicated.<\/jats:p>","DOI":"10.3390\/jcm14165918","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T15:19:02Z","timestamp":1755789542000},"page":"5918","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cervical Regeneration Following Monopolar Electrosurgical Conization: A Prospective Evaluation of Volume, Length, and Transformation Zone Reformation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-9153","authenticated-orcid":false,"given":"\u015eule","family":"G\u00fcl Ayd\u0131n","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Adana City Training and Research Hospital, Adana 01230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6454-6470","authenticated-orcid":false,"given":"Sevda","family":"Ba\u015f","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, Adana 01230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-4554","authenticated-orcid":false,"given":"Fatma","family":"\u00d6zmen","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, Training and Research Hospital, Ordu University School of Medicine, Ordu 52000, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-3393","authenticated-orcid":false,"given":"\u015eeyma","family":"Ya\u015far","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, \u0130n\u00f6n\u00fc University School of Medicine, Malatya 44280, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-4487","authenticated-orcid":false,"given":"Zeynel Abidin","family":"Ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pathology, Adana City Training and Research Hospital, Adana 01230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-0212","authenticated-orcid":false,"given":"Ahmet Zeki","family":"Nessar","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Osmaniye State Hospital, Osmaniye 80000, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-6628","authenticated-orcid":false,"given":"Sevtap","family":"Seyfettino\u011flu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, Adana 01230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-9053","authenticated-orcid":false,"given":"Mehmet Ali","family":"Narin","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, Adana 01230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1471-0528.2012.03275.x","article-title":"Regeneration of uterine cervix at 6 months after large loop excision of the transformation zone for cervical intraepithelial neoplasia","volume":"119","author":"Papoutsis","year":"2012","journal-title":"BJOG Int. 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