{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T17:02:56Z","timestamp":1784480576471,"version":"3.55.0"},"reference-count":73,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Most patients with hypertension exhibit elevated and detectable levels of natriuretic peptides, particularly BNP and NT-proBNP, as well as troponin concentrations. However, the prognostic relevance of this finding has not been clearly established in patients who have hypertension without heart failure (HF). In this review, we aimed to evaluate the prognostic utility of BNP\/NT-proBNP alongside troponin T\/I for risk stratification in hypertensive patients, excluding those with HF. Methods: This systematic review was registered in PROSPERO (CRD42024552031). A systematic literature search was conducted using two online databases, Ovid Medline and Web of Science, to identify studies. Data retrieved from articles were used in line with the PRISMA statement guidelines. Participants were aged \u2265 18 years with hypertension. The primary end point was a major adverse cardiac event (MACE) and its individual components. Descriptive synthesis was performed, and data are presented in tabular form. Results: Seventeen studies (70,021 participants) were retrieved for analysis comprising eight prospective cohort studies, six randomized controlled trials, and three retrospective studies. The review evaluated cardiac biomarkers: BNP (n = 6), NT proBNP (n=9), troponin T (n = 4), and troponin I (n = 7). Studies predicted composite MACE (n = 8), all-cause mortality (n = 7), HF (n = 6), and atrial fibrillation (n = 3) outcomes. Cardiac biomarkers showed a strong association with reported outcomes. However, heterogeneity in biomarker thresholds and methodologies limited comparability. Conclusions: The obtained results suggest that elevated cardiac biomarkers BNP\/NT-proBNP and troponin I are associated with significantly higher risk of MACE and are powerful predictors in clinical setting. However, large-scale studies are required to validate the robustness and prognostic utility of these biomarkers<\/jats:p>","DOI":"10.3390\/jcm14175935","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:50:31Z","timestamp":1755863431000},"page":"5935","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Prognostic Significance of Circulating Biomarkers of End Organ Damage in Hypertension"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6210-3062","authenticated-orcid":false,"given":"Elliot","family":"Mbeta","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at Liverpool John Moores University (LJMU), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool L8 8TX, UK"},{"name":"School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Williams","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at Liverpool John Moores University (LJMU), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool L8 8TX, UK"},{"name":"School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-4430","authenticated-orcid":false,"given":"James","family":"Yates","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at Liverpool John Moores University (LJMU), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool L8 8TX, UK"},{"name":"School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2355-2011","authenticated-orcid":false,"given":"Rajiv","family":"Sankaranarayanan","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at Liverpool John Moores University (LJMU), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool L8 8TX, UK"},{"name":"Department of Cardiology, Aintree University Hospital, University Hospitals of Liverpool Group, Liverpool L9 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-1489","authenticated-orcid":false,"given":"Peter","family":"Penson","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at Liverpool John Moores University (LJMU), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool L8 8TX, UK"},{"name":"School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at Liverpool John Moores University (LJMU), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool L8 8TX, UK"},{"name":"Danish Centre for Health Services Research, Department of Clinical Medicine, Aalborg University, 9220 Aalborg East, Denmark"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L8 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-5236","authenticated-orcid":false,"given":"Garry","family":"McDowell","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at Liverpool John Moores University (LJMU), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool L8 8TX, UK"},{"name":"School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L8 8TX, UK"},{"name":"Research Laboratory, Liverpool Heart and Chest Hospital, Liverpool L14 3PE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"James","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: A comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc. 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