{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:02Z","timestamp":1787028662757,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Accurate surgical margin delineation is essential in the treatment of non-melanoma skin cancers (NMSCs), particularly basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), to reduce recurrence and metastasis. Dermoscopy improves diagnostic accuracy for skin tumors, but its utility for preoperative margin assessment remains underexplored. To compare dermoscopy-guided versus clinical visual inspection for preoperative margin assessment in NMSC excision, focusing on histological clearance rates and surgical outcomes. Methods: This systematic review and meta-analysis followed PRISMA 2020 guidelines. MEDLINE, Cochrane CENTRAL, Scopus, and Web of Science were searched from inception to 1 July 2025. Eligible studies included adult patients undergoing surgical excision of histologically confirmed BCC or cSCC, with preoperative margin evaluation using either dermoscopy or clinical examination. The primary outcome was the rate of complete histological excision. Study quality was assessed using the Newcastle\u2013Ottawa Scale. A random-effects meta-analysis using the Freeman\u2013Tukey transformation was performed. Results: Nine cohort studies comprising 900 NMSC lesions were included. Dermoscopy-guided excision demonstrated pooled histological clearance of 98.7% (95% CI: 97\u201399.8%), compared to 80\u201394% with clinical assessment. Moderate heterogeneity was observed (I2 = 42%). However, variability in study design and limited data for cSCC restricted broader conclusions. Conclusions: Dermoscopy may enhance margin assessment and histological clearance in NMSC surgery, especially for BCC. Further standardized, high-quality studies are needed to confirm its role in surgical planning and extend evidence to SCC.<\/jats:p>","DOI":"10.3390\/jcm14176014","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:26:31Z","timestamp":1756189591000},"page":"6014","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Versus Dermoscopic Evaluation of Tumor Margins Prior to Surgical Excision\u2014A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1831-6337","authenticated-orcid":false,"given":"Anestis","family":"Chrysostomidis","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"First Department of Dermatology, School of Medicine, Faculty of Health Sciences, Aristotle University, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1332-0479","authenticated-orcid":false,"given":"Evangelos","family":"Kostares","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Saramantos","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-7295","authenticated-orcid":false,"given":"Konstantinos","family":"Lallas","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, School of Medicine, Faculty of Health Sciences, Aristotle University, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7193-0964","authenticated-orcid":false,"given":"Aimilios","family":"Lallas","sequence":"additional","affiliation":[{"name":"First Department of Dermatology, School of Medicine, Faculty of Health Sciences, Aristotle University, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-9882","authenticated-orcid":false,"given":"Maria","family":"Kantzanou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Tilaveridis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3896-0309","authenticated-orcid":false,"given":"Athanassios","family":"Kyrgidis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/archderm.1997.03890420073008","article-title":"Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992","volume":"133","author":"Gray","year":"1997","journal-title":"Arch. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jaad.2009.11.698","article-title":"How to diagnose nonpigmented skin tumors: A review of vascular structures seen with dermoscopy: Part I. Melanocytic skin tumors","volume":"63","author":"Zalaudek","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_3","first-page":"45","article-title":"Dermoscopy as an adjunct to surgical excision of nonmelanoma Skin lesions: A systematic review and Meta-analysis","volume":"15","author":"Hurley","year":"2022","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e15711","DOI":"10.1111\/dth.15711","article-title":"The effect of dermoscopy in assisting on defining surgical margins of basal cell carcinoma","volume":"35","author":"Chen","year":"2022","journal-title":"Dermatol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e14196","DOI":"10.1111\/dth.14196","article-title":"Effectiveness of dermoscopy in the demarcation of surgical margins in slow Mohs surgery","volume":"33","author":"Litaiem","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_6","unstructured":"(2016). Quality Statement 3: Dermoscopy (Standard No. QS130). Updated 2024."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jaad.2024.07.1505","article-title":"Dermatoscopic predictors of histopathologically aggressive basal cell carcinoma and their positive impact of subtype prediction by human readers","volume":"91","author":"Camela","year":"2024","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/bjd.12634","article-title":"Dermoscopy uncovers clinically undetectable pigmentation in basal cell carcinoma","volume":"170","author":"Lallas","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jaad.2013.10.003","article-title":"Accuracy of dermoscopic criteria for discriminating superficial from other subtypes of basal cell carcinoma","volume":"70","author":"Lallas","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1111\/jdv.13988","article-title":"Dermoscopy of small-size basal cell carcinoma: A case-control study","volume":"31","author":"Longo","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1097\/DSS.0000000000002471","article-title":"Dermoscopic Findings in the Presurgical Evaluation of Basal Cell Carcinoma. A Prospective Study","volume":"47","author":"Conforti","year":"2021","journal-title":"Dermatol. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1001\/archderm.144.9.1120","article-title":"Dermoscopic evaluation of amelanotic and hypomelanotic melanoma","volume":"144","author":"Menzies","year":"2008","journal-title":"Arch. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/bjd.19660","article-title":"Incomplete surgical excision of keratinocyte skin cancers: A systematic review and meta-analysis","volume":"184","author":"Nolan","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Liu, Z., Huang, S., Li, F., Wang, X., Liu, M., Wong, H.S., Jiang, J., Zhou, Y., and Wang, D. (2023). The efficacy of dermoscopy in defining the surgical margins of cutaneous squamous cell carcinoma: A retrospective study. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1141820"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wojtowicz, I., and \u017bychowska, M. (2025). Dermoscopy of Basal Cell Carcinoma Part 3: Differential Diagnosis, Treatment Monitoring and Novel Technologies. Cancers, 17.","DOI":"10.3390\/cancers17061025"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jaad.2005.04.087","article-title":"Basal cell carcinoma treated with Mohs surgery in Australia II. Outcome at 5-year follow-up","volume":"53","author":"Leibovitch","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/bjd.17507","article-title":"Diagnostic accuracy of ex vivo fluorescence confocal microscopy in Mohs surgery of basal cell carcinomas: A prospective study on 753 margins","volume":"180","author":"Longo","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/DSS.0000000000004455","article-title":"Surgical Margins of Nonmelanoma Skin Cancers in Mohs Surgery: Dermoscopy Versus Naked Eye","volume":"51","author":"Aoki","year":"2025","journal-title":"Dermatol. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/09546634.2012.672711","article-title":"Preoperative margin detection by digital dermoscopy in the traditional surgical excision of cutaneous squamous cell carcinomas","volume":"24","author":"Carducci","year":"2013","journal-title":"J. Dermatol. Treat."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1524-4725.2010.01870.x","article-title":"Margin detection using digital dermatoscopy improves the performance of traditional surgical excision of basal cell carcinomas of the head and neck","volume":"37","author":"Carducci","year":"2011","journal-title":"Dermatol. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/j.1468-3083.2010.03652.x","article-title":"Dermoscopy-guided surgery in basal cell carcinoma","volume":"24","author":"Caresana","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1111\/jdv.12689","article-title":"Narrow-margin excision is a safe, reliable treatment for well-defined, primary pigmented basal cell carcinoma: An analysis of 288 lesions in Japan","volume":"29","author":"Ito","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lupu, M., Voiculescu, V.M., Caruntu, A., Tebeica, T., and Caruntu, C. (2021). Preoperative Evaluation through Dermoscopy and Reflectance Confocal Microscopy of the Lateral Excision Margins for Primary Basal Cell Carcinoma. Diagnostics, 11.","DOI":"10.3390\/diagnostics11010120"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"793","DOI":"10.25259\/IJDVL_325_2022","article-title":"Use of preoperative and perioperative ex vivo dermoscopy for precise mapping of margins for standard surgical excision of primary basal cell carcinoma","volume":"89","author":"Savant","year":"2023","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s40257-018-0367-4","article-title":"Noninvasive Imaging Tools in the Diagnosis and Treatment of Skin Cancers","volume":"19","author":"Bakos","year":"2018","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/jdv.17790","article-title":"Clinical and dermatoscopic predictors of squamous cell carcinoma of the lips: A case-control, multicentric study","volume":"36","author":"Lallas","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/bjd.13510","article-title":"The clinical and dermoscopic features of invasive cutaneous squamous cell carcinoma depend on the histopathological grade of differentiation","volume":"172","author":"Lallas","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/bjd.12749","article-title":"Applicability of dermoscopy for evaluation of patients\u2019 response to nonablative therapies for the treatment of superficial basal cell carcinoma","volume":"170","author":"Apalla","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.jaad.2018.12.026","article-title":"The diagnostic accuracy of dermoscopy for basal cell carcinoma: A systematic review and meta-analysis","volume":"80","author":"Reiter","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_31","first-page":"CD011901","article-title":"Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults","volume":"12","author":"Dinnes","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/jdv.14803","article-title":"Tracking actinic keratosis of face and scalp treated with 0.015% ingenol mebutate to identify clinical and dermoscopic predictors of treatment response","volume":"32","author":"Pampena","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jaad.2015.12.038","article-title":"Standardization of terminology in dermoscopy\/dermatoscopy: Results of the third consensus conference of the International Society of Dermoscopy","volume":"74","author":"Kittler","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e2022189","DOI":"10.5826\/dpc.1204a189","article-title":"Instructional Strategies to Enhance Dermoscopic Image Interpretation Education: A Review of the Literature","volume":"12","author":"Tran","year":"2022","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Halip, I.-A., V\u00e2\u0163\u0103, D., Statescu, L., Salahoru, P., Patra\u015fcu, A.I., Olinici, D.T., Tarcau, B., Popescu, I.-A., Mocanu, M., and Constantin, A.-M. (2022). Assessment of Basal Cell Carcinoma Using Dermoscopy and High Frequency Ultrasound Examination. Diagnostics, 12.","DOI":"10.3390\/diagnostics12030735"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e13271","DOI":"10.1111\/srt.13271","article-title":"Non-invasive imaging techniques in presurgical margin assessment of basal cell carcinoma: Current evidence","volume":"29","author":"Janowska","year":"2023","journal-title":"Ski. Res. Technol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6014\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:32:47Z","timestamp":1760034767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":36,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcm14176014"],"URL":"https:\/\/doi.org\/10.3390\/jcm14176014","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]}}}