{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:49:02Z","timestamp":1793411342475,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Cervical cancer is considered to be a global health challenge, particularly in low- and middle-income countries. Romania reports one of the highest burdens in Europe due to limited access to screening and HPV vaccination. Chemoradiotherapy is standard for locally advanced disease, but the impact on quality of life (QoL) for a low- and middle-income population has not yet been explored. This study aims to evaluate the effect of chemoradiotherapy on the QoL of cervical cancer survivors in the Romanian population. Methods: This prospective observational study included 111 patients with stage I\u2013IV cervical cancer undergoing chemoradiotherapy. QoL was assessed using the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire before, during, and after treatment. Demographic and clinical data were collected. The statistical analyses included t-tests, ANOVA, and linear mixed-effects models to evaluate changes over time and the influence of sociodemographic and treatment-related factors. Results: FACT-G scores significantly increased after treatment, with improvements in physical and functional well-being. Better before-treatment QoL was associated with urban residence, early-stage disease, marital status, and higher education. Among treatment toxicities, only nausea had a statistically significant negative effect on QoL during treatment, while other toxicities showed no significant impact. Conclusions: Chemoradiotherapy in cervical cancer patients was not associated with a substantial deterioration in quality of life during treatment and was followed by significant improvement after therapy completion. These findings highlight a favorable short-term QoL trajectory and emphasize the need for longitudinal studies to assess whether such benefits are maintained over the long term.<\/jats:p>","DOI":"10.3390\/jcm14176023","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T10:35:17Z","timestamp":1756204517000},"page":"6023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Chemoradiotherapy on Quality of Life in Cervical Cancer Patients: A Prospective Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9177-3305","authenticated-orcid":false,"given":"Maria-Alexandra","family":"Barbu","sequence":"first","affiliation":[{"name":"Department 8\u2014Radiology, Oncology, Hematology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, Romania"},{"name":"MedEuropa Center of Oncology and Radiation Therapy, Dobroesti 20a, 022343 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4385-9475","authenticated-orcid":false,"given":"Miruna","family":"Ghigeanu","sequence":"additional","affiliation":[{"name":"Oncology Department, Col\u021bea Clinical Hospital, Ion C. Br\u0103tianu 1, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bahaa-Eddin","sequence":"additional","affiliation":[{"name":"Oncology Department, Col\u021bea Clinical Hospital, Ion C. Br\u0103tianu 1, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Michire","sequence":"additional","affiliation":[{"name":"Radiotherapy Department, Sanador Oncology Center, Strada Sevastopol, Nr 4, Sector 1, 010993 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Hanu","sequence":"additional","affiliation":[{"name":"Prof. Dr. Matei Bal\u0219 Institute of Infectious Diseases, 021105 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gentiana","family":"Eremia","sequence":"additional","affiliation":[{"name":"Prof. Dr. Al. Trestioreanu Oncology Institute, Radiotherapy 2 Department, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ianina","family":"Draganescu","sequence":"additional","affiliation":[{"name":"Prof. Dr. Al. Trestioreanu Oncology Institute, Radiotherapy 2 Department, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Birca","sequence":"additional","affiliation":[{"name":"Prof. Dr. Al. Trestioreanu Oncology Institute, Radiotherapy 2 Department, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1601-0580","authenticated-orcid":false,"given":"Mihai-Teodor","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Prof. Dr. Al. Trestioreanu Oncology Institute, Radiotherapy 2 Department, 022328 Bucharest, Romania"},{"name":"Prof. Dr. Al. Trestioreanu Oncology Discipline, Department 8, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref_1","unstructured":"(2025, May 06). Cancer (IARC) TIA for R on. Global Cancer Observatory. Available online: https:\/\/gco.iarc.fr\/."},{"key":"ref_2","unstructured":"Globocan (2025, January 06). Romania 2022, Factsheet. Available online: https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/642-romania-fact-sheet.pdf."},{"key":"ref_3","unstructured":"(2025, May 06). Cervical Cancer. 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