{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:34:18Z","timestamp":1792096458165,"version":"4.4.0"},"reference-count":47,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Pregnancy-Related Acute kidney injury (PRAKI) is a critical complication of pregnancy, defined by the sudden deterioration in renal function during gestation or within the initial six weeks postpartum. Pregnancy is thought to increase the risk of acute kidney injury (AKI) by 51%. This is linked to the anatomical alterations that occur during pregnancy and special conditions, such as preeclampsia\/eclampsia. PRAKI\u2019s epidemiology and outcome vary between developed and developing nations. PRAKI is an uncommon entity in high-income countries; however, its incidence has recently increased. The aim of this systematic review is to evaluate the maternal and perinatal outcomes and risk factors affecting pregnancies affected by AKI. Methods: Comprehensive research was performed in PubMed\/Medline, Scopus, and Google Scholar electronic databases from 2015 up to January 2025, using the terms AKI, PRAKI, sepsis, preeclampsia\/eclampsia, liver enzymes, low platelet count (HELLP) syndrome, and pregnancy. After a thorough assessment, 25 full-text articles were obtained. Results: Our results revealed that preeclampsia, eclampsia, HELLP syndrome, and antepartum and postpartum hemorrhage predispose women to PRAKI. Other unusual factors, like disseminated intravascular coagulation (DIC) or hemolytic uremic syndrome (HUS), should not be underestimated. Furthermore, the latest published data showed unfavorable maternal and fetal outcomes in pregnancies affected by AKI compared to the general population. Conclusions: PRAKI constitutes a serious pregnancy complication that requires immediate treatment. The higher prevalence of PRAKI in developing countries (4\u201326%) versus wealthy nations (1.0\u20132.8%) has considerably indicated the impact of socioeconomic status and the accessibility of health services.<\/jats:p>","DOI":"10.3390\/jcm14176031","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T14:43:18Z","timestamp":1756219398000},"page":"6031","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pregnancy-Related Acute Kidney Injury: Causes and Its Impact on Perinatal Outcomes\u2014A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Emmanuel N.","family":"Kontomanolis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3853-8352","authenticated-orcid":false,"given":"Ioannis","family":"Prokopakis","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, General Hospital of Athens \u2018ALEXANDRA\u2019, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7229-9983","authenticated-orcid":false,"given":"Antonios","family":"Koutras","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, General Hospital of Athens \u2018ALEXANDRA\u2019, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Andreou","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Laiko General Hospital of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3419-6450","authenticated-orcid":false,"given":"Dionysios","family":"Metaxas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erythros Stavros Hospital, 11526 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Boulieris","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, General Hospital of Athens \u2018ALEXANDRA\u2019, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-3048","authenticated-orcid":false,"given":"Eleftherios","family":"Zachariou","sequence":"additional","affiliation":[{"name":"1st Gynecology Department, Metropolitan General Hospital, 14671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-0608","authenticated-orcid":false,"given":"Ioakeim","family":"Sapantzoglou","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, General Hospital of Athens \u2018ALEXANDRA\u2019, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0160-7755","authenticated-orcid":false,"given":"Dimitrios","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"Athens Naval and Veterans Hospital, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios-Chrysovalantis","family":"Palios","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University General Hospital of Larissa, Mezourlo, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-4701","authenticated-orcid":false,"given":"Charalampos","family":"Karachalios","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Laiko General Hospital of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Papadimitriou","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Laiko General Hospital of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Daglas","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Laiko General Hospital of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Chionis","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Laiko General Hospital of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0615-3597","authenticated-orcid":false,"given":"Antonios","family":"Lagadas","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Laiko General Hospital of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6454-7855","authenticated-orcid":false,"given":"Paraskevas","family":"Perros","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Laiko General Hospital of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrneph.2011.14","article-title":"Classification and staging of acute kidney injury: Beyond the RIFLE and AKIN criteria","volume":"7","author":"Ricci","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R204","DOI":"10.1186\/cc2872","article-title":"Acute renal failure\u2014Definition, outcome measures, animal models, fluid therapy and information technology needs: The Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group","volume":"8","author":"Bellomo","year":"2004","journal-title":"Crit. Care"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Liu, D., He, W., Li, Y., Xiong, M., Wang, L., Huang, J., Jia, L., Yuan, S., and Nie, S. (2019). Epidemiology of acute kidney injury in hospitalized pregnant women in China. BMC Nephrol., 20.","DOI":"10.1186\/s12882-019-1255-8"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.ackd.2013.01.012","article-title":"Renal Physiology of Pregnancy","volume":"20","author":"Cheung","year":"2013","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1007\/s40620-022-01349-2","article-title":"Pregnancy-related acute kidney injury in the African continent: Where do we stand? A systematic review","volume":"35","author":"Shalaby","year":"2022","journal-title":"J. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin. Pract."},{"key":"ref_7","unstructured":"American College of Obstetricians and Task Force on Hypertension in Pregnancy, Hypertension in pregnancy (2013). Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy. Obstet. Gynecol., 122, 1122\u20131131."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s13224-014-0502-y","article-title":"Preeclampsia-eclampsia","volume":"64","author":"Gupte","year":"2014","journal-title":"J. Obstet. Gynecol. India"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000525492","article-title":"Pregnancy-Related Acute Kidney Injury\u2014Do We Know What to Do?","volume":"147","author":"Shah","year":"2022","journal-title":"Nephron"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ahmed, D.M., Mengistu, T.S., and Endalamaw, A.G. (2018). Incidence and factors associated with outcomes of uterine rupture among women delivered at Felegehiwot referral hospital, Bahir Dar, Ethiopia: Cross sectional study. BMC Pregnancy Childbirth, 18.","DOI":"10.1186\/s12884-018-2083-8"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1053\/j.ackd.2013.02.002","article-title":"Acute kidney injury in pregnancy-current status","volume":"20","author":"Acharya","year":"2013","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"151317","DOI":"10.1016\/j.semnephrol.2023.151317","article-title":"Pregnancy-Associated Acute Kidney Injury in Low-Resource Settings: Progress Over the Last Decade","volume":"42","author":"Davidson","year":"2022","journal-title":"Semin. Nephrol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.semnephrol.2017.05.010","article-title":"Acute Kidney Injury in Pregnancy","volume":"37","author":"Jim","year":"2017","journal-title":"Semin. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10928-020-09677-1","article-title":"Anatomical and physiological alterations of pregnancy","volume":"47","author":"Kazma","year":"2020","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.joad.2015.08.002","article-title":"Relation between acute kidney injury and pregnancy-related factors","volume":"5","author":"Siribamrungwong","year":"2016","journal-title":"J. Acute Dis."},{"key":"ref_16","first-page":"e58982","article-title":"Acute Kidney Injury in Pregnancy: A Prospective Study","volume":"16","author":"Choudhary","year":"2024","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s40620-017-0466-y","article-title":"Acute kidney injury in pregnancy with special reference to pregnancy-specific disorders: A hospital based study (2014-2016)","volume":"31","author":"Prakash","year":"2018","journal-title":"J. Nephrol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.5005\/japi-11001-0064","article-title":"Pregnancy-related Acute Kidney Injury in Public Hospital in South India: Changing Trends","volume":"70","author":"Sahay","year":"2022","journal-title":"J. Assoc. Physicians India"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.4103\/jfmpc.jfmpc_924_23","article-title":"Risk factors and fetomaternal outcome in pregnancy-related acute kidney injury","volume":"12","author":"Sandilya","year":"2023","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/jfcm.jfcm_117_22","article-title":"Feto-maternal outcome of pregnancy related acute kidney injury in a North Indian population","volume":"29","author":"Sachan","year":"2022","journal-title":"J. Fam. Community Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/0971-4065.194394","article-title":"Pregnancy-related acute kidney injury: An analysis of 165 cases","volume":"27","author":"Mahesh","year":"2017","journal-title":"Indian. J. Nephrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3109\/0886022X.2016.1164015","article-title":"Postpartum acute kidney injury: A review of 99 cases","volume":"38","author":"Eswarappa","year":"2016","journal-title":"Ren. Fail."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.3109\/0886022X.2015.1074493","article-title":"Acute kidney injury in pregnancy--a single center experience","volume":"37","author":"Gopalakrishnan","year":"2015","journal-title":"Ren. Fail."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"493","DOI":"10.4103\/1319-2442.284025","article-title":"The changing face of pregnancy-related acute kidney injury from eastern part of India: A hospital-based, prospective, observational study","volume":"31","author":"Chaudhury","year":"2020","journal-title":"Saudi J. Kidney Dis. Transpl."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.26574\/maedica.2022.17.1.80","article-title":"Renal Outcomes of Pregnancy-Related Acute Kidney Injury: A Single Centre Experience in India","volume":"17","author":"Yadav","year":"2022","journal-title":"Maedica"},{"key":"ref_26","first-page":"e49610","article-title":"A Retrospective Study on Clinical Outcomes of Pregnancy-Related Acute Kidney Injury Patients at a South Indian Tertiary Care Hospital","volume":"15","author":"Anvar","year":"2023","journal-title":"Cureus"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1007\/s11255-023-03484-6","article-title":"Clinical characteristics and prognosis of pregnancy-related acute kidney injury: A case series study","volume":"55","author":"Lu","year":"2023","journal-title":"Int. Urol. Nephrol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Li, X., Wu, X., Zhang, M., Xu, L., Li, G., Wen, Y., and Wang, W. (2021). Pregnancy-related acute kidney injury at high altitude: A retrospective observational study in a single center. BMC Nephrol., 22.","DOI":"10.1186\/s12882-021-02418-7"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0300060520988388","article-title":"Clinical characteristics and prognosis of postpartum acute kidney injury","volume":"49","author":"Shu","year":"2021","journal-title":"J. Int. Med Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.12669\/pjms.40.10.9228","article-title":"Frequency of adverse perinatal outcomes in patients with pregnancy related acute renal (kidney) injury in a tertiary care hospital","volume":"40","author":"Mohammad","year":"2024","journal-title":"Pak. J. Med. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"535","DOI":"10.29271\/jcpsp.2023.05.535","article-title":"Acute Kidney Injury Due to Obstetric Complications","volume":"33","author":"Mal","year":"2023","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_32","first-page":"e3362","article-title":"Characteristics and Outcome of Obstetric Acute Kidney Injury in Pakistan: A Single-center Prospective Observational Study","volume":"10","author":"Bokhari","year":"2018","journal-title":"Cureus"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Cooke, W.R., Hemmil\u00e4, U.K., Craik, A.L., Mandula, C.J., Mvula, P., Msusa, A., Dreyer, G., and Evans, R. (2018). Incidence, aetiology and outcomes of obstetric-related acute kidney injury in Malawi: A prospective observational study. BMC Nephrol., 19.","DOI":"10.1186\/s12882-018-0824-6"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s40620-021-01133-8","article-title":"Acute kidney injury during pregnancy and puerperium: An Egyptian hospital-based study","volume":"34","author":"Gaber","year":"2021","journal-title":"J. Nephrol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s40620-023-01822-6","article-title":"Risk factors and outcomes associated with pregnancy-related acute kidney injury in a high-risk cohort of women in Nigeria","volume":"37","author":"Waziri","year":"2024","journal-title":"J. Nephrol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.4103\/1319-2442.275487","article-title":"Pregnancy-related acute kidney injury: Etiologies and short-term outcomes in a tertiary hospital in Southwest Nigeria","volume":"30","author":"Adejumo","year":"2019","journal-title":"Saudi J. Kidney Dis. Transpl."},{"key":"ref_37","first-page":"627","article-title":"Incidence of Pregnancy-Related Acute Kidney Injury in a Low Resource Setting: A Prospective Study","volume":"64","author":"Orhewere","year":"2023","journal-title":"Niger. Med. J."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Berhe, E., Teka, H., Abraha, H.E., Abera, B.T., Gebru, M.A., Gebremariam, T., Yahya, M., Amare, B., Tadesse, H., and Gidey, H. (2024). Characteristics and outcome of pregnancy-related acute kidney injury in a teaching hospital in a low-resource setting: A five-year retrospective review. BMC Nephrol., 25.","DOI":"10.1186\/s12882-024-03616-9"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Meca, D.C., Varlas, V.N., Mehedin\u021bu, C., and C\u00eerstoiu, M.M. (2023). Correlations between Maternal and Fetal Outcomes in Pregnant Women with Kidney Failure. J. Clin. Med., 12.","DOI":"10.3390\/jcm12030832"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1681\/ASN.2014100954","article-title":"Characteristics and Outcomes of AKI Treated with Dialysis during Pregnancy and the Postpartum Period","volume":"26","author":"Hildebrand","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.5005\/jp-journals-10071-24325","article-title":"Etiology of Pregnancy-related Acute Kidney Injury among Obstetric Patients in India: A Systematic Review","volume":"26","author":"Pandey","year":"2022","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.4103\/1319-2442.270268","article-title":"Changing epidemiology of acute kidney injury in pregnancy: A journey of four decades from a developing country","volume":"30","author":"Prakash","year":"2019","journal-title":"Saudi J. Kidney Dis. Transpl."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bpobgyn.2018.12.005","article-title":"Acute kidney injury in pregnancy including renal disease diagnosed in pregnancy","volume":"57","author":"Hall","year":"2019","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_44","first-page":"129","article-title":"Pregnancy Related Acute Renal Failure in a Tertiary Care Hospital in Bangladesh","volume":"13","author":"Rahman","year":"2012","journal-title":"J. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"E29563","DOI":"10.1097\/MD.0000000000029563","article-title":"Incidence of acute kidney injury during pregnancy and its prognostic value for adverse clinical outcomes: A systematic review and meta-analysis","volume":"101","author":"Trakarnvanich","year":"2022","journal-title":"Medicine"},{"key":"ref_46","unstructured":"(2025, March 16). Pregnancy-Related Acute Renal Failure: A Ten-Year Experience\u2014PubMed, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/21422644\/."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1590\/S1516-31802006000500004","article-title":"Risk factors for death among critically ill patients with acute renal failure","volume":"124","author":"Mota","year":"2006","journal-title":"Sao Paulo Med. J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6031\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:33:03Z","timestamp":1760034783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":47,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcm14176031"],"URL":"https:\/\/doi.org\/10.3390\/jcm14176031","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]}}}