{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:01:18Z","timestamp":1789398078300,"version":"build-2803163510"},"reference-count":69,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Cardiovascular disease (CVD) and edentulism are major public health challenges with shared risk factors and overlapping inflammatory pathways. This study investigates the association between complete tooth loss and CVD. (2) Methods: Data were analyzed from the 2015\u20132018 National Health and Nutrition Examination Survey (NHANES) dataset using Poisson regression analysis to examine the relationship between CVD and complete edentulism, adjusting for age, sex, education, family income-to-poverty ratio, race\/ethnicity, diabetes status, and BMI. Of the 11,287 participants, 1763 individuals (15.62%) were completely edentulous, and 9524 (84.38%) retained some or all of their dentition. (3) Results: Individuals with cardiovascular conditions, including myocardial infarction (PR = 1.55; 95% CI: 1.23\u20131.98), coronary heart disease (PR = 1.44; 95% CI: 1.13\u20131.85), congestive heart failure (PR = 1.58; 95% CI: 1.22\u20132.07), and stroke (PR = 1.46; 95% CI: 1.13\u20131.90), demonstrated a higher prevalence of complete edentulism compared to those without these conditions, after adjusting for key demographic and health-related confounders (p &lt; 0.01). (4) Conclusions: These findings suggest a statistical association between CVD and complete edentulism in U.S. adults. However, due to the cross-sectional nature of this study, causal relationships cannot be inferred, and further longitudinal studies are needed to understand the bidirectional mechanisms between CVD and complete edentulism.<\/jats:p>","DOI":"10.3390\/jcm14176035","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T14:43:18Z","timestamp":1756219398000},"page":"6035","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association Between Cardiovascular Disease and Complete Edentulism in U.S. Adults"],"prefix":"10.3390","volume":"14","author":[{"given":"Saud","family":"Alyahya","sequence":"first","affiliation":[{"name":"Kuwait Ministry of Health, Kuwait City 15462, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2357-7818","authenticated-orcid":false,"given":"Basel","family":"Hamoud","sequence":"additional","affiliation":[{"name":"Kuwait Ministry of Health, Kuwait City 15462, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alqattan","sequence":"additional","affiliation":[{"name":"Kuwait Ministry of Health, Kuwait City 15462, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Almasoud","sequence":"additional","affiliation":[{"name":"Kuwait Ministry of Health, Kuwait City 15462, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Almehjan","sequence":"additional","affiliation":[{"name":"Kuwait Ministry of Health, Kuwait City 15462, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashed","family":"Alajmi","sequence":"additional","affiliation":[{"name":"Kuwait Ministry of Health, Kuwait City 15462, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Alhazmi","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Faculty of Dental Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend","family":"Alqaderi","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Dental Medicine, Tufts University, Boston, MA 02111, USA"},{"name":"Dasman Diabetes Institute, Kuwait City 15462, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mendoza, M.F., Anzelmo, M.A., Suan, N.M., Cuccia, C.S., and Lavie, C.J. 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