{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:11:09Z","timestamp":1790716269733,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health, under the National Recovery and Resilience Plan (NRRP)\u2014Mission 6 (Health), Component 2\u2014Investment 2.1","award":["PNRR-TR1-2023-12378226"],"award-info":[{"award-number":["PNRR-TR1-2023-12378226"]}]},{"name":"Italian Ministry of Health, under the National Recovery and Resilience Plan (NRRP)\u2014Mission 6 (Health), Component 2\u2014Investment 2.1","award":["H13C24000190006"],"award-info":[{"award-number":["H13C24000190006"]}]},{"name":"European Union\u2014NextGenerationEU","award":["PNRR-TR1-2023-12378226"],"award-info":[{"award-number":["PNRR-TR1-2023-12378226"]}]},{"name":"European Union\u2014NextGenerationEU","award":["H13C24000190006"],"award-info":[{"award-number":["H13C24000190006"]}]},{"name":"Fondazione Don Carlo Gnocchi","award":["PNRR-TR1-2023-12378226"],"award-info":[{"award-number":["PNRR-TR1-2023-12378226"]}]},{"name":"Fondazione Don Carlo Gnocchi","award":["H13C24000190006"],"award-info":[{"award-number":["H13C24000190006"]}]},{"name":"Italian Ministry of Health","award":["PNRR-TR1-2023-12378226"],"award-info":[{"award-number":["PNRR-TR1-2023-12378226"]}]},{"name":"Italian Ministry of Health","award":["H13C24000190006"],"award-info":[{"award-number":["H13C24000190006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Soft tissue sarcomas (STSs) are rare and heterogeneous malignancies requiring a multidisciplinary approach to diagnosis and treatment. Advances in surgical techniques, chemotherapy, and radiotherapy have improved survival rates but often result in significant functional impairments, particularly in patients undergoing limb-sparing procedures. Rehabilitation is crucial for restoring mobility and independence, with recent studies emphasizing the importance of personalized rehabilitation protocols tailored to specific surgical interventions. Quantitative assessments, such as 3D motion capture and surface electromyography, provide objective insights into gait performance and motor function, enabling more precise rehabilitation strategies to optimize recovery. Methods: This study evaluated gait performance in 21 patients with lower-limb impairment following limb-sparing surgery for STS. Patients underwent two instrumented gait assessments using marker-based 3D motion capture and surface electromyography to measure spatiotemporal gait parameters, joint kinematics, and muscle activity. Independence in the activity of daily living was assessed with the modified Barthel Index in both timepoints. Results: Following rehabilitation, patients demonstrated significant improvements in functional independence, as reflected by an increase in the modified Barthel Index (p &lt; 0.001). Gait analysis revealed increased walking speed, stride length, cadence, and improved joint range of motion at the hip, knee, and ankle, though electromyographic analysis showed no statistically significant differences in muscle activation patterns or co-contraction indices. Conclusions: These findings underscore the importance of a rehabilitation programs personalized on gait strategies. A deeper understanding of motor adaptations based on sarcoma location and surgical approach could further refine rehabilitation protocols, ultimately enhancing patient outcomes and quality of life.<\/jats:p>","DOI":"10.3390\/jcm14176061","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:31:12Z","timestamp":1756373472000},"page":"6061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rehabilitation Outcomes Following Surgical Management of Lower-Limb Soft Tissue Sarcomas: Insights from Gait Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-831X","authenticated-orcid":false,"given":"Marco","family":"Germanotta","sequence":"first","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-9075","authenticated-orcid":false,"given":"Francesca","family":"Falchini","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5214-8248","authenticated-orcid":false,"given":"Arianna","family":"Pavan","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0727-6578","authenticated-orcid":false,"given":"Stefania","family":"Lattanzi","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0661-6442","authenticated-orcid":false,"given":"Laura","family":"Cortellini","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beniamino","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Plastic-Reconstructive and Aesthetic Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7858-1528","authenticated-orcid":false,"given":"Stefania","family":"Tenna","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Plastic-Reconstructive and Aesthetic Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Valeri","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Plastic-Reconstructive and Aesthetic Surgery, Universit\u00e0 Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8120-2801","authenticated-orcid":false,"given":"Chiara","family":"Pagnoni","sequence":"additional","affiliation":[{"name":"Operative Research Unit, Soft-Tissue Sarcomas Surgery Department, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Passa","sequence":"additional","affiliation":[{"name":"Operative Research Unit, Soft-Tissue Sarcomas Surgery Department, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0248-5238","authenticated-orcid":false,"given":"Michela","family":"Angelucci","sequence":"additional","affiliation":[{"name":"Operative Research Unit, Soft-Tissue Sarcomas Surgery Department, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vincenzi","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Alloni","sequence":"additional","affiliation":[{"name":"Operative Research Unit, Soft-Tissue Sarcomas Surgery Department, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-9977","authenticated-orcid":false,"given":"Irene Giovanna","family":"Aprile","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Valeri","sequence":"additional","affiliation":[{"name":"Operative Research Unit, Soft-Tissue Sarcomas Surgery Department, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"ref_1","first-page":"200","article-title":"Soft-tissue Sarcoma in Adults: An Update on the Current State of Histiotype-specific Management in an Era of Personalized Medicine","volume":"70","author":"Gamboa","year":"2020","journal-title":"CA A Cancer J. 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