{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:54:32Z","timestamp":1776214472497,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objective: The relationship between Helicobacter pylori (H. pylori) infection and inflammatory bowel disease (IBD) remains controversial. While H. pylori is a well-established pathogen in gastroduodenal diseases, emerging evidence suggests it may exert immunomodulatory effects that influence the pathogenesis and clinical course of IBD. This review aims to explore the association between H. pylori infection and IBD, focusing on infection prevalence among IBD patients, the potential protective or harmful roles of H. pylori, and the impact of eradication therapy on IBD onset and activity. Methods: A comprehensive literature search was conducted using PubMed up to, including clinical studies, meta-analyses, systematic reviews, and observational data. A total of 40 studies met the inclusion criteria and were critically reviewed. Results: The majority of studies indicate a significantly lower prevalence of H. pylori infection among patients with IBD compared to the general population. Several meta-analyses support a potential protective effect, particularly in Crohn\u2019s disease and among CagA-positive H. pylori strains. However, data on the impact of eradication therapy on IBD progression remain inconclusive. Some studies suggest a higher relapse risk post-eradication, while others report no change in disease activity. Variability in outcomes may be influenced by geographic, demographic, and methodological differences, as well as disease activity at the time of eradication. Conclusions: Although numerous studies support an inverse association between H. pylori infection and IBD, the nature and direction of this relationship remain unclear. Given the complex interplay between host immunity, gut microbiota, and antibiotic exposure, the decision to eradicate H. pylori in IBD patients should be individualized. Further prospective studies are needed to clarify the immunological and microbiological mechanisms underlying this association and to inform clinical guidelines.<\/jats:p>","DOI":"10.3390\/jcm14176083","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:29:18Z","timestamp":1756376958000},"page":"6083","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Controversies in the Relationship Between Helicobacter pylori Infection and Inflammatory Bowel Disease: Narrative Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-7988","authenticated-orcid":false,"given":"Jonatan","family":"Vukovic","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia"},{"name":"Department of Internal Medicine, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4669-666X","authenticated-orcid":false,"given":"Ivana","family":"Jukic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia"},{"name":"Faculty of Health Sciences, University of Split, Rudjera Boskovica 35, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Moodley, Y., Linz, B., Bond, R.P., Nieuwoudt, M., Soodyall, H., Schlebusch, C.M., Bernh\u00f6ft, S., Hale, J., Suerbaum, S., and Mugisha, L. (2012). Age of the association between Helicobacter pylori and man. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002693"},{"key":"ref_2","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"1","author":"Warren","year":"1983","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","article-title":"Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis","volume":"153","author":"Hooi","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1523-5378.2009.00703.x","article-title":"The epidemiology of Helicobacter pylori and public health implications","volume":"14","author":"Azevedo","year":"2009","journal-title":"Helicobacter"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hel.12165","article-title":"Epidemiology of Helicobacter pylori infection","volume":"19","author":"Eusebi","year":"2014","journal-title":"Helicobacter"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Nguyen, J., Kotilea, K., Bontems, P., and Miendje Deyi, V.Y. (2023). Helicobacter pylori Infections in Children. Antibiotics, 12.","DOI":"10.3390\/antibiotics12091440"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/oxfordjournals.epirev.a018040","article-title":"Helicobacter pylori: Epidemiology and routes of transmission","volume":"22","author":"Brown","year":"2000","journal-title":"Epidemiol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.trecan.2021.05.007","article-title":"Helicobacter pylori: A stealth assassin","volume":"7","author":"Wroblewski","year":"2021","journal-title":"Trends Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11950","DOI":"10.3748\/wjg.v20.i34.11950","article-title":"Extraintestinal manifestations of Helicobacter pylori: A concise review","volume":"20","author":"Wong","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/gutjnl-2012-302084","article-title":"European Helicobacter Study Group. Management of Helicobacter pylori infection\u2014The Maastricht IV\/ Florence Consensus Report","volume":"61","author":"Malfertheiner","year":"2012","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wang, L., Cao, Z.M., Zhang, L.L., Dai, X.C., Liu, Z.J., Zeng, Y., Li, X.Y., Wu, Q.J., and Lv, W.L. (2022). Helicobacter Pylori and Autoimmune Diseases: Involving Multiple Systems. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.833424"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/ibd.21116","article-title":"Association between Helicobacter pylori infection and inflammatory bowel disease: A meta-analysis and systematic review of the literature","volume":"16","author":"Luther","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chc.2010.01.007","article-title":"Inflammatory bowel disease","volume":"19","author":"Szigethy","year":"2010","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cyto.2004.07.012","article-title":"New cytokine therapeutics for inflammatory bowel disease","volume":"28","author":"Stokkers","year":"2004","journal-title":"Cytokine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrd1986","article-title":"Evolving knowledge and therapy of inflammatory bowel disease","volume":"5","author":"Korzenik","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/01.MIB.0000195385.19268.68","article-title":"Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities","volume":"12","author":"Hanauer","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Liu, Y., Li, J., Yang, G., Meng, D., Long, X., and Wang, K. (2024). Global burden of inflammatory bowel disease in the elderly: Trends from 1990 to 2021 and projections to 2051. Front. Aging, 5.","DOI":"10.3389\/fragi.2024.1479928"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.micinf.2009.06.005","article-title":"Role of Nod2 in the development of Crohn\u2019s disease","volume":"11","author":"Yamamoto","year":"2009","journal-title":"Microbes Infect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.disamonth.2017.07.001","article-title":"A comprehensive review and update on Crohn\u2019s disease","volume":"64","author":"Gajendran","year":"2018","journal-title":"Dis. Mon."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.34172\/aim.2021.44","article-title":"The Relationship Between Helicobacter Pylori and Inflammatory Bowel Disease","volume":"24","author":"Zhong","year":"2021","journal-title":"Arch. Iran. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.15403\/jgld.2014.1121.272.hpy","article-title":"Helicobacter Pylori Eradication Therapy Is Not Associated with the Onset of Inflammatory Bowel Diseases. A Case-Control Study","volume":"27","author":"Rosania","year":"2018","journal-title":"J. Gastrointestin Liver Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.5217\/ir.2018.00044","article-title":"Seven Days Triple Therapy for Eradication of Helicobacter Pylori Does Not Alter the Disease Activity of Patients with Inflammatory Bowel Disease","volume":"16","author":"Shinzaki","year":"2018","journal-title":"Intest. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Lahat, A., Kopylov, U., Neuman, S., Levhar, N., Yablecovitch, D., Avidan, B., Weiss, B., Ben-Horin, S., Eliakim, R., and on behalf of the Israeli IBD research Network (IIRN) (2017). Helicobacter Pylori Prevalence and Clinical Significance in Patients with Quiescent Crohn\u2019s Disease. BMC Gastroenterol., 17.","DOI":"10.1186\/s12876-017-0588-7"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Gravina, A.G., Pellegrino, R., Iascone, V., Palladino, G., Federico, A., and Zagari, R.M. (2024). Impact of Helicobacter pylori Eradication on Inflammatory Bowel Disease Onset and Disease Activity: To Eradicate or Not to Eradicate?. Diseases, 12.","DOI":"10.3390\/diseases12080179"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Dilaghi, E., Felici, E., Lahner, E., Pilozzi, E., Furio, S., Lucchini, L., Quatrale, G., Piccirillo, M., Parisi, P., and Curto, S. (2024). Helicobacter Pylori infection in children with inflammatory bowel disease: A prospective multicenter study. BMC Pediatr., 24.","DOI":"10.1186\/s12887-024-04902-z"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e13092","DOI":"10.1111\/hel.13092","article-title":"ESPGHAN  H. pylori special interest group. Helicobacter pylori infection found during upper endoscopy performed for the diagnosis of celiac, inflammatory bowel diseases, and eosinophilic esophagitis: A multicenter pediatric European study","volume":"29","author":"Kotilea","year":"2024","journal-title":"Helicobacter"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bretto, E., Frara, S., Armandi, A., Caviglia, G.P., Saracco, G.M., Bugianesi, E., Pitoni, D., and Ribaldone, D.G. (2024). Helicobacter pylori in Inflammatory Bowel Diseases: Active Protagonist or Innocent Bystander?. Antibiotics, 13.","DOI":"10.3390\/antibiotics13030267"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"17562848231177610","DOI":"10.1177\/17562848231177610","article-title":"Helicobacter pylori in children: Think before you kill the bug!","volume":"16","author":"Ravikumara","year":"2023","journal-title":"Therap. Adv. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3000605211060648","DOI":"10.1177\/03000605211060648","article-title":"Effect of sequential eradication therapy on serum osteoprotegerin levels in patients with Helicobacter pylori infection and co-existing inflammatory bowel disease","volume":"49","author":"Murad","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3748\/wjg.v27.i7.545","article-title":"Helicobacter pylori: Commensal, symbiont or pathogen?","volume":"27","author":"Reshetnyak","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e000679","DOI":"10.1136\/bmjpo-2020-000679","article-title":"Helicobacter pylori infection in children","volume":"4","author":"Escobedo","year":"2020","journal-title":"BMJ Paediatr. Open."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s41419-018-0982-2","article-title":"Helicobacter pylori infection and inflammatory bowel disease: A crosstalk between upper and lower digestive tract","volume":"9","author":"Yu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_36","first-page":"349","article-title":"Does Helicobacter pylori eradication therapy trigger or protect against Crohn\u2019s disease?","volume":"79","author":"Murad","year":"2016","journal-title":"Acta Gastroenterol. Belg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000445985","article-title":"Helicobacter pylori: Does Gastritis Prevent Colitis?","volume":"1","author":"Arnold","year":"2016","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/diseases3020034","article-title":"Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies","volume":"3","author":"Robinson","year":"2015","journal-title":"Diseases"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/hel.12157","article-title":"Helicobacter pylori and nonmalignant diseases","volume":"19","author":"Ierardi","year":"2014","journal-title":"Helicobacter"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Wang, Z., Zhao, S., Zhong, X., Su, Y., Song, Y., Li, J., and Shi, Y. (2024). Debate on the relationship between Helicobacter pylori infection and inflammatory bowel disease: A bibliometric analysis. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1479941"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e70014","DOI":"10.1002\/jgh3.70014","article-title":"Bibliometric analysis of the correlation between  H. pylori and inflammatory bowel disease","volume":"8","author":"Li","year":"2024","journal-title":"JGH Open"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e34882","DOI":"10.1097\/MD.0000000000034882","article-title":"The association between Helicobacter pylori infection and inflammatory bowel disease in children: A systematic review with meta-analysis","volume":"102","author":"Kong","year":"2023","journal-title":"Medicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.3748\/wjg.v29.i30.4604","article-title":"Immune response modulation in inflammatory bowel diseases by Helicobacter pylori infection","volume":"29","author":"Teixeira","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"He, J., Liu, Y., Ouyang, Q., Li, R., Li, J., Chen, W., Hu, W., He, L., Bao, Q., and Li, P. (2022). Helicobacter pylori and unignorable extragastric diseases: Mechanism and implications. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.972777"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e057214","DOI":"10.1136\/bmjopen-2021-057214","article-title":"Helicobacter pylori infection in patients with inflammatory bowel diseases: A single-centre, prospective, observational study in Egypt","volume":"12","author":"Youssef","year":"2022","journal-title":"BMJ Open"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"17562848211004493","DOI":"10.1177\/17562848211004493","article-title":"The role of gastrointestinal pathogens in inflammatory bowel disease: A systematic review","volume":"14","author":"Axelrad","year":"2021","journal-title":"Therap. Adv. Gastroenterol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Gravina, A.G., Priadko, K., Ciamarra, P., Granata, L., Facchiano, A., Miranda, A., Dallio, M., Federico, A., and Romano, M. (2020). Extra-Gastric Manifestations of Helicobacter pylori Infection. J. Clin. Med., 9.","DOI":"10.3390\/jcm9123887"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.3748\/wjg.v26.i28.4076","article-title":"Helicobacter pylori infection: Beyond gastric manifestations","volume":"26","author":"Santos","year":"2020","journal-title":"World. J. Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/apt.15770","article-title":"Systematic review: Gastrointestinal infection and incident inflammatory bowel disease","volume":"51","author":"Axelrad","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/apt.15306","article-title":"Systematic review with meta-analysis: Association between Helicobacter pylori CagA seropositivity and odds of inflammatory bowel disease","volume":"50","author":"Tepler","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_51","first-page":"10509","article-title":"Correlation Between Helicobacter Pylori Infection and Crohn\u2019s Disease: A Meta-Analysis","volume":"23","author":"Wang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_52","first-page":"81","article-title":"Inverse association between Helicobacter pylori and inflammatory bowel disease: Myth or fact?","volume":"89","author":"Kayali","year":"2018","journal-title":"Acta Biomed."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e1773","DOI":"10.1097\/MD.0000000000001773","article-title":"Enterohepatic Helicobacter Species as a Potential Causative Factor in Inflammatory Bowel Disease: A Meta-Analysis","volume":"94","author":"Yu","year":"2015","journal-title":"Medicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.3748\/wjg.v20.i21.6374","article-title":"Helicobacter pylori infection and inflammatory bowel disease: Is there a link?","volume":"20","author":"Papamichael","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4161\/gmic.19181","article-title":"Helicobacter pylori DNA\u2019s anti-inflammatory effect on experimental colitis","volume":"3","author":"Owyang","year":"2012","journal-title":"Gut Microbes"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4166\/kjg.2009.53.6.341","article-title":"The prevalence of Helicobacter pylori infection in Korean patients with inflammatory bowel disease, a multicenter study","volume":"53","author":"Song","year":"2009","journal-title":"Korean J. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.3748\/wjg.v19.i28.4576","article-title":"Helicobacter pylori and Crohn\u2019s disease: A retrospective single-center study from China","volume":"19","author":"Xiang","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_58","first-page":"485","article-title":"The relationship between inflammatory bowel disease and Helicobacter pylori across East Asian, European and Mediterranean countries: A meta-analysis","volume":"33","author":"Imawana","year":"2020","journal-title":"Ann. Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e12741","DOI":"10.1111\/hel.12741","article-title":"Review: Extragastric diseases and Helicobacter pylori","volume":"25","author":"Pellicano","year":"2020","journal-title":"Helicobacter"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.3748\/wjg.v21.i15.4750","article-title":"Helicobacter pylori infection and inflammatory bowel disease in Asians: A meta-analysis","volume":"21","author":"Wu","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/2050640615580889","article-title":"The association between Helicobacter pylori infection and inflammatory bowel disease based on meta-analysis","volume":"3","author":"Rokkas","year":"2015","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/gutjnl-2015-310545","article-title":"Dual role of Helicobacter and Campylobacter species in IBD: A systematic review and meta-analysis","volume":"66","author":"Kaakoush","year":"2017","journal-title":"Gut"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2019.04.016","article-title":"Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses","volume":"157","author":"Piovani","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/5584_2019_367","article-title":"Current and Future Treatment of Helicobacter Pylori Infections","volume":"1149","author":"Matsumoto","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2108655","DOI":"10.1080\/19490976.2022.2108655","article-title":"The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management","volume":"14","author":"Sadeghi","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_66","first-page":"101234","article-title":"Next-generation probiotics delivery: Innovations and applications of single-cell encapsulation","volume":"61","author":"Aijun","year":"2024","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1007\/s10620-017-4561-7","article-title":"Association of Helicobacter pylori and Crohn\u2019s Disease Incidence: An Inversion Reaction?","volume":"62","author":"Bartels","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Alotaibi, A.D., Al-Abdulwahab, A.A., Ismail, M.H., AlElyani, J.M., Alamri, T.A., Alsulaiman, R.M., Alhafid, I.A., Alzahrani, I.M., AlSulaiman, R.S., and Althubaity, A. (2025). Prevalence of H. Pylori in inflammatory bowel disease patients and its association with severity. BMC Gastroenterol., 25.","DOI":"10.1186\/s12876-025-03892-1"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6083\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:34:21Z","timestamp":1760034861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":68,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcm14176083"],"URL":"https:\/\/doi.org\/10.3390\/jcm14176083","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]}}}