{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:58:07Z","timestamp":1779361087326,"version":"3.51.4"},"reference-count":46,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Society of Allergology, Asthma, and Clinical Immunology (SIAAIC)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organs and systems with a broad and heterogeneous spectrum of clinical manifestations. National disease-specific datasets and registries are crucial for clinical research since they can provide real-world and long-term data about clinical aspects, biomarkers, and treatments. Registries collect data from actual patients over time, outside the controlled environment of randomized controlled trials. This can help enhance the understanding of the natural history of a disease, provide information about how treatments work in everyday settings and elucidate potential variations in care and outcomes across different geographic areas. Here, we present a protocol for the creation of a standardized national disease-specific dataset for patients with SLE\u2014the Systemic Lupus Erythematous Network (LUNET) Registry\u2014which will facilitate data sharing, cross-comparison, and interoperability among centers. The LUNET registry is intended to serve as a comprehensive primary data source, capturing real-world longitudinal clinical information and the heterogeneity of patient presentations that are often underrepresented in traditional clinical trials. Ultimately, the LUNET registry will help to optimize SLE management in routine clinical practice by enabling the compilation of real-world evidence to inform clinical decision-making and health policy.<\/jats:p>","DOI":"10.3390\/jcm14176197","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T13:01:13Z","timestamp":1756818073000},"page":"6197","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The LUNET Project: Developing the Italian Systemic Erythematous Lupus Network"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7599-5426","authenticated-orcid":false,"given":"Ilaria","family":"Mormile","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7249-7616","authenticated-orcid":false,"given":"Luisa","family":"Brussino","sequence":"additional","affiliation":[{"name":"SCDU Immunologia e Allergologia AO Ordine Mauriziano, University of Turin, 10128 Turin, Italy"},{"name":"Dipartimento di Scienze Mediche, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio Walter","family":"Canonica","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy"},{"name":"Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Cortini","sequence":"additional","affiliation":[{"name":"In&Fo&Med, Via San Gregorio 12, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Costantino","sequence":"additional","affiliation":[{"name":"Allergology, Clinical Immunology and Reumatology Unit, Carlo Poma Hospital, 46100 Mantua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Dagna","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS Ospedale San Raffaele, 20132 Milan, Italy"},{"name":"Faculty of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Del Giacco","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Della Casa","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-5886","authenticated-orcid":false,"given":"Mario","family":"Di Gioacchino","sequence":"additional","affiliation":[{"name":"Synergo-Institute of Clinical Immunotherapy and Advanced Biological Treatments, 66100 Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Emmi","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy"},{"name":"Clinical Medicine and Rheumatology Unit, Cattinara University Hospital, 34100 Trieste, Italy"},{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Melbourne 3168, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Moroncini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Marche Polytechnic University, 60121 Ancona, Italy"},{"name":"Department of Internal Medicine, Marche University Hospital, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-4320","authenticated-orcid":false,"given":"Simone","family":"Negrini","sequence":"additional","affiliation":[{"name":"SCDU Immunologia e Allergologia AO Ordine Mauriziano, University of Turin, 10128 Turin, Italy"},{"name":"Dipartimento di Scienze Mediche, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-5069","authenticated-orcid":false,"given":"Daniela","family":"Pacella","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9184-5089","authenticated-orcid":false,"given":"Paola","family":"Parronchi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy"},{"name":"Immunology and Cell Therapy Unit, Careggi University Hospital, 50139 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-6446","authenticated-orcid":false,"given":"Vincenzo","family":"Patella","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine ASL Salerno, \u2018Santa Maria Della Speranza\u2019 Hospital, 84091 Salerno, Italy"},{"name":"Postgraduate Programme in Allergy and Clinical Immunology, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-032X","authenticated-orcid":false,"given":"Francesca Wanda","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy"},{"name":"WAO Center of Excellence, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Sirena","sequence":"additional","affiliation":[{"name":"In&Fo&Med, Via San Gregorio 12, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-2093","authenticated-orcid":false,"given":"Massimo","family":"Triggiani","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, University of Salerno, 84084 Fisciano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4567-8216","authenticated-orcid":false,"given":"Angelo","family":"Vacca","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area, UOC Medicina Interna \u201cGuido Baccelli\u201d, University of Bari Aldo Moro, Policlinico, 70126 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0347-2540","authenticated-orcid":false,"given":"Amato","family":"de Paulis","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy"},{"name":"WAO Center of Excellence, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1002\/art.34473","article-title":"Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus","volume":"64","author":"Petri","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/annrheumdis-2018-214819","article-title":"2019 European League Against Rheumatism\/American College of Rheumatology classification criteria for systemic lupus erythematosus","volume":"78","author":"Aringer","year":"2019","journal-title":"Ann. 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(2024). Epidemiology of SLE in Italy: An observational study using a primary care database. Lupus Sci. Med., 11.","DOI":"10.1136\/lupus-2024-001162"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6197\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:38:01Z","timestamp":1760035081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":46,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcm14176197"],"URL":"https:\/\/doi.org\/10.3390\/jcm14176197","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]}}}