{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:43:18Z","timestamp":1760060598250,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dong-A ST Co., Ltd., Seoul, Republic of Korea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Erosive gastritis has various causes, and severe damage to the mucosa can cause symptoms such as indigestion, abdominal pain, nausea, and vomiting. The condition is defined by visible erosions that emerge as discrete defects in the gastric mucosa. Stillen\u00ae is a natural mucosal-protective agent derived from Artemisia asiatica, but its comparative efficacy versus rebamipide remains unclear. This systematic review and network meta-analysis evaluated whether Stillen\u00ae leads to non-inferior endoscopic improvement outcomes compared to rebamipide in patients with acute or chronic gastritis. Methods: Databases including PubMed, EMBASE, Cochrane Library, RISS, KoreaMed, ClinicalTrials.gov, and ICTRP were searched through 15 August 2025. Eligible studies were randomized controlled trials (RCTs) comparing Stillen\u00ae with rebamipide or other mucosal-protective agents in gastritis. Two reviewers independently screened studies, extracted data, and evaluated the risk of bias. The primary outcome was the improvement rate (\u226550% erosion reduction); the secondary outcome was the cure rate (complete erosion resolution) and safety outcomes. Results: A total of 11 RCTs met the inclusion criteria, with 9 contributing to the primary network analysis. Stillen\u00ae was non-inferior to rebamipide in terms of the improvement rate at 2 weeks (OR: 1.11, 95% CI: (0.88, 1.39) in FAS) and in pooled analysis across 2, 3, and 4 weeks. Cure rates showed no significant differences between the two agents. The safety outcomes were comparable, with no significant differences. Most studies were assessed as having a low risk of bias, and the certainty of evidence was rated as high for most efficacy outcomes. Conclusions: The network meta-analysis suggests that Stillen\u00ae is non-inferior to rebamipide in improving erosions in patients with acute or chronic gastritis.<\/jats:p>","DOI":"10.3390\/jcm14176209","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T15:02:57Z","timestamp":1756825377000},"page":"6209","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy and Safety of Stillen\u00ae and Rebamipide in Patients with Acute or Chronic Gastritis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-6546","authenticated-orcid":false,"given":"Hyejoo","family":"Lee","sequence":"first","affiliation":[{"name":"Academic Research Service Headquarters, LSK Global PS, Seoul 04535, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Rae","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Academic Research Service Headquarters, LSK Global PS, Seoul 04535, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7048-6366","authenticated-orcid":false,"given":"Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Academic Research Service Headquarters, LSK Global PS, Seoul 04535, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1044-0440","authenticated-orcid":false,"given":"Woo Chul","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0016-5107(95)70043-9","article-title":"Interobserver agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteers","volume":"42","author":"Laine","year":"1995","journal-title":"Gastrointest. Endosc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1016\/S0002-9270(98)00565-6","article-title":"Guidelines for the management of Helicobacter pylori infection","volume":"93","author":"Cw","year":"1998","journal-title":"Am. J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/CMR.00054-05","article-title":"Pathogenesis of Helicobacter pylori infection","volume":"19","author":"Kusters","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s40264-014-0207-2","article-title":"Cardiovascular risk with non-steroidal anti-inflammatory drugs: Clinical implications","volume":"37","author":"Bello","year":"2014","journal-title":"Drug Saf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0140-6736(16)32404-7","article-title":"Peptic ulcer disease","volume":"390","author":"Lanas","year":"2017","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/gutjnl-2015-309252","article-title":"Kyoto global consensus report on Helicobacter pylori gastritis","volume":"64","author":"Sugano","year":"2015","journal-title":"Gut"},{"key":"ref_7","first-page":"728","article-title":"Guidelines for prevention of NSAID-related ulcer complications","volume":"104","author":"Lanza","year":"2009","journal-title":"Off. J. Am. Coll. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.14309\/ajg.0000000000001538","article-title":"ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease","volume":"117","author":"Katz","year":"2022","journal-title":"Off. J. Am. Coll. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/j.gastro.2017.01.031","article-title":"The risks and benefits of long-term use of proton pump inhibitors: Expert review and best practice advice from the American Gastroenterological Association","volume":"152","author":"Freedberg","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1001\/jama.2009.722","article-title":"Acid-suppressive medication use and the risk for hospital-acquired pneumonia","volume":"301","author":"Herzig","year":"2009","journal-title":"JAMA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1046\/j.1365-2036.2000.00768.x","article-title":"Potential gastrointestinal effects of long-term acid suppression with proton pump inhibitors","volume":"14","author":"Laine","year":"2000","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/archinternmed.2010.73","article-title":"Proton pump inhibitors and risk for recurrent Clostridium difficile infection","volume":"170","author":"Linsky","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/joim.12698","article-title":"Long-term use of proton pump inhibitors, dose\u2013response relationship and associated risk of ischemic stroke and myocardial infarction","volume":"283","author":"Sehested","year":"2018","journal-title":"J. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/jamainternmed.2013.14673","article-title":"Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the intensive care unit","volume":"174","author":"MacLaren","year":"2014","journal-title":"JAMA Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s40262-019-00844-3","article-title":"A systematic review of gastric acid-reducing agent-mediated drug\u2013drug interactions with orally administered medications","volume":"59","author":"Patel","year":"2020","journal-title":"Clin. Pharmacokinet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4292\/wjgpt.v5.i2.57","article-title":"Histamine2-receptor antagonists: Rapid development of tachyphylaxis with repeat dosing","volume":"5","author":"McRorie","year":"2014","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.3748\/wjg.v10.i16.2379","article-title":"DA-9601 for erosive gastritis: Results of a double-blind placebo-controlled phase III clinical trial","volume":"10","author":"Seol","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.3346\/jkms.2017.32.11.1807","article-title":"Evaluation of the efficacy and safety of DA-9601 versus its new formulation, DA-5204, in patients with gastritis: Phase III, randomized, double-blind, non-inferiority study","volume":"32","author":"Choi","year":"2017","journal-title":"J. Korean Med. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e38801","DOI":"10.1097\/MD.0000000000038801","article-title":"DA-9601 has protective effects comparable to those of proton pump inhibitor and rebamipide against nonsteroidal anti-inflammatory drugs-induced upper and lower gastrointestinal bleeding in patients with rheumatoid arthritis: A nationwide study using Korean Health Insurance Review and Assessment Service database","volume":"103","author":"So","year":"2024","journal-title":"Medicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"101753","DOI":"10.4292\/wjgpt.v16.i1.101753","article-title":"Rebamipide in gastric mucosal protection and healing: An Asian perspective","volume":"16","author":"Kak","year":"2025","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"ref_21","first-page":"215","article-title":"Efficacy and Safety of Albis (R) in Acute and Chronic Patients with Gastritis: A Double-blind, Placebo-controlled, Randomized Multi-center Study","volume":"42","author":"Han","year":"2011","journal-title":"Korean J. Gastrointest. Endosc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"841","DOI":"10.5009\/gnl20338","article-title":"Efficacy and safety of rebamipide versus its new formulation, AD-203, in patients with erosive gastritis: A randomized, double-blind, active control, noninferiority, multicenter, phase 3 study","volume":"15","author":"Kim","year":"2021","journal-title":"Gut Liver"},{"key":"ref_23","first-page":"125","article-title":"Single blinded, randomized, active drug comparative, multi-center study to evaluate the therapeutic efficacy of gliptide (R) tab (sulglycotide 200 mg) in gastritis patients; phase IV study","volume":"35","author":"Jeong","year":"2007","journal-title":"Korean J. Gastrointest. Endosc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.7704\/kjhugr.2013.13.3.173","article-title":"Therapeutic Efficacy of Gliptide (Sulglycotide 200 mg): A Double Blinded, Randomized, Active Drug Comparative, Multicenter Study","volume":"13","author":"Moon","year":"2013","journal-title":"Korean J. Helicobacter Up. Gastrointest. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2702089","DOI":"10.1155\/cjgh\/2702089","article-title":"A Phase 2, Multi-Center, Randomized, Double-Blind, Parallel-Group Trial to Evaluate the Efficacy and Safety of CKD-495 in Patients with Acute and Chronic Gastritis","volume":"2025","author":"Park","year":"2025","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e35926","DOI":"10.1097\/MD.0000000000035926","article-title":"Efficacy and safety of CKD-495 in acute and chronic gastritis: A Phase III superiority clinical trial","volume":"102","author":"Seo","year":"2023","journal-title":"Medicine"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Boutron, I., Page, M.J., Higgins, J.P., Altman, D.G., Lundh, A., Hr\u00f3bjartsson, A., and Group, C.B.M. (2019). Considering bias and conflicts of interest among the included studies. Cochrane Handbook for Systematic Reviews of Interventions, Cochrane.","DOI":"10.1002\/9781119536604.ch7"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: An emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Albadrani, M., Eltahir, H.M., Mahmoud, A.B., and Abouzied, M.M. (2025). Evaluating the Safety and Efficacy of Malaria Preventive Measures in Pregnant Women with a Focus on HIV Status: A Systematic Review and Network Meta-Analysis. J. Clin. Med., 14.","DOI":"10.3390\/jcm14103396"},{"key":"ref_30","first-page":"245","article-title":"Measures of effect size for categorical data","volume":"247","author":"Fleiss","year":"1994","journal-title":"Handb. Res. Synth."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13643-019-0985-9","article-title":"Network meta-analysis of randomised trials of pharmacological, psychotherapeutic, exercise and collaborative care interventions for depressive symptoms in patients with coronary artery disease: Hybrid systematic review of systematic reviews protocol","volume":"8","author":"Doyle","year":"2019","journal-title":"Syst. Rev."},{"key":"ref_32","unstructured":"Lee, Y.C., and Kim, J.I. (2025, August 24). A Multicenter, Active-Controlled, Randomized, Double-Blind, Parallel-Group Clinical Trial to Evaluate the Efficacy of 4-Week Treatment with Stillen in Patients with Acute or Chronic Gastritis, Available online: https:\/\/clinicaltrials.gov\/study\/NCT01817556?cond=NCT01817556&rank=1."},{"key":"ref_33","unstructured":"(2014). Guidelines for Submitting Data for Each Stage of Indirect Comparisons in Clinical Utility Assessment, The Health Insurance Review and Assessment Service."},{"key":"ref_34","unstructured":"(2021). Guidelines for Economic Evaluation of Pharmaceuticals, The Health Insurance Review and Assessment Service."},{"key":"ref_35","unstructured":"Cho, S.W. (2025, August 24). Phase 2b Multi-Center Clinical Trial to Clarify the Efficacy and Target Population of DA9601 in Patients with Acute and Chronic Gastritis, and to Determine the Optimal Clinical Dosage and Administration, Available online: https:\/\/clinicaltrials.gov\/study\/NCT07139886?cond=NCT07139886&rank=1."},{"key":"ref_36","first-page":"125","article-title":"Therapeutic Efficacy of Gliptide (Sulglycotide) on Gastritis\u2014A Single Blind, Randomized, Active Drug Comparative, Multi-center, Phase IV Study","volume":"35","author":"Kim","year":"2005","journal-title":"Korean J. Gastrointest. Endosc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/10715760000301301","article-title":"The role of neutrophils and inflammation in gastric mucosal injury","volume":"33","author":"Yoshikawa","year":"2000","journal-title":"Free Radic. Res."},{"key":"ref_38","first-page":"174","article-title":"General Pharmacology of Artemisia Extract Powder, DA-9601","volume":"4","author":"Lee","year":"1996","journal-title":"J. Appl. Pharmacol. Off. J. Korean Soc. Appl. Pharmacol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6209\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:38:15Z","timestamp":1760035095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":38,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcm14176209"],"URL":"https:\/\/doi.org\/10.3390\/jcm14176209","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,9,2]]}}}