{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:09:23Z","timestamp":1793844563152,"version":"4.6.1"},"reference-count":47,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Tooth autotransplantation is a natural tooth replacement method that preserves the periodontal ligament, supporting root development and alveolar bone remodeling. Unlike dental implants, autotransplanted teeth maintain sensory function and adapt better to the mouth. Although once overlooked, new surgical, imaging, and regenerative advances have revived interest in this technique. This narrative review explores the renewed interest in tooth autotransplantation by assessing its benefits, success rates, technological advancements, and role in modern dentistry while evaluating its advantages, limitations, and potential impact on dental care. Methods: A narrative approach was used to provide a comprehensive and descriptive overview of current knowledge on tooth autotransplantation. A literature search was conducted in PubMed, Scopus, and Google Scholar using keywords such as \u201ctooth autotransplantation\u201d, \u201cbiological tooth replacement\u201d, \u201cperiodontal ligament\u201d, and \u201cdental implants alternative\u201d. English-language articles published between 2000 and 2025 were included, covering clinical trials, reviews, and relevant case reports. Selection focused on studies discussing biological mechanisms, clinical techniques, technological advances, and treatment outcomes. Results: Success rates range from 80% to 95%, with better predictability in younger patients with immature donor teeth. Long-term viability depends on preserving the PDL and performing atraumatic extractions. However, challenges such as root resorption, ankylosis, and appropriate case selection remain significant considerations. Technological advancements, including CBCT, 3D-printed surgical guides, and biomimetic storage media, have improved surgical precision and clinical outcomes. Conclusions: Tooth autotransplantation is an effective and cost-effective alternative to dental implants, particularly for growing patients or when implants are not suitable. While success depends on surgical skill and proper case selection, improvements in imaging and regenerative techniques have made outcomes more predictable. Future advances in bioengineering, AI-based planning, and regenerative therapies are likely to expand their use in modern dentistry.<\/jats:p>","DOI":"10.3390\/jcm14176249","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T10:55:37Z","timestamp":1756983337000},"page":"6249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Tooth Autotransplantation in Contemporary Dentistry: A Narrative Review of Its Clinical Applications and Biological Basis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-2194","authenticated-orcid":false,"given":"Aida","family":"Meto","sequence":"first","affiliation":[{"name":"Department of Dentistry, Faculty of Dental Sciences, University of Aldent, 1007 Tirana, Albania"},{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41125 Modena, Italy"},{"name":"Department of Dental Research Cell, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune 411018, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kreshnik","family":"\u00c7ota","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Dental Sciences, University of Aldent, 1007 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-2453","authenticated-orcid":false,"given":"Agron","family":"Meto","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Dental Sciences, University of Aldent, 1007 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Bara","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2299-300X","authenticated-orcid":false,"given":"Luca","family":"Boschini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Tooth auto-transplantation as an alternative treatment option: A literature review","volume":"10","author":"Omerca","year":"2013","journal-title":"Dent. Res. J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Doomen, R., Barendregt, D., Temmerman, L., De Roo, N., and De Pauw, G. (Dent. Traumatol., 2025). Premolar Autotransplantation to the Anterior Maxilla Region-Aesthetic Outcome and Patient Satisfaction, Dent. Traumatol., Online ahead of print.","DOI":"10.1111\/edt.13057"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ajodo.2023.11.011","article-title":"Survival of retained permanent canines after autotransplantation: A retrospective cohort study","volume":"165","author":"Krupp","year":"2024","journal-title":"Am. J. Orthod. Dentofacial Orthop."},{"key":"ref_4","unstructured":"Guerini, V. (1909). A History of Dentistry from the Most Ancient Times Until the End of the Eighteenth Century, Lea & Febiger. Available online: https:\/\/catalog.lib.unc.edu\/catalog\/UNCb1905784."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0030-4220(70)90143-X","article-title":"The replantation and transplantation of teeth. A review","volume":"29","author":"Natiella","year":"1970","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/edt.12641","article-title":"Jens Ove Andreasen, 1935\u20132020 Father of Dental Traumatology","volume":"37","author":"Andersson","year":"2021","journal-title":"Dent. Traumatol."},{"key":"ref_7","first-page":"512","article-title":"A clinical and radiographic study of 76 autotransplanted third molars","volume":"78","author":"Andreasen","year":"1970","journal-title":"Scand. J. Dent. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.surge.2012.10.003","article-title":"Developments in autotransplantation of teeth","volume":"11","author":"Cross","year":"2013","journal-title":"Surgeon"},{"key":"ref_9","unstructured":"Pasqualini, U., and Pasqualini, M.E. (2009). Treatise of Implant Dentistry: The Italian Tribute to Modern Implantology, Ariesdue."},{"key":"ref_10","first-page":"92","article-title":"Autogenous tooth transplantation: An alternative to dental implant placement?","volume":"67","author":"Clokie","year":"2001","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/edt.13025","article-title":"Autotransplantation of Premolars to the Anterior Maxilla: A Long-Term Retrospective Cohort Study of Survival, Success, Esthetic, and Patient-Reported Outcome With up to 38-Year Follow-Up","volume":"41","author":"Akhlef","year":"2025","journal-title":"Dent. Traumatol."},{"key":"ref_12","first-page":"e30491","article-title":"Tooth Autotransplantation as an Alternative Biological Treatment: A Literature Review","volume":"14","author":"Kakde","year":"2022","journal-title":"Cureus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/adj.12420","article-title":"Autotransplantation: A viable treatment option for adolescent patients with significantly compromised teeth","volume":"61","author":"Ong","year":"2016","journal-title":"Aust. Dent. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000351894","article-title":"Periodontal Ligament and Alveolar Bone in Health and Adaptation: Tooth Movement","volume":"18","author":"Jiang","year":"2016","journal-title":"Front. Oral Biol."},{"key":"ref_15","first-page":"e27875","article-title":"Autotransplantation of the Lower Posterior Teeth: A Comprehensive Review","volume":"14","author":"Algubeal","year":"2022","journal-title":"Cureus"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/dvdy.10404","article-title":"Role of Hertwig\u2019s epithelial root sheath cells in tooth root development","volume":"228","author":"Oishi","year":"2003","journal-title":"Dev. Dyn."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.17796\/jcpd.35.2.97816254u2140x88","article-title":"Tooth autotransplantation as a treatment option: A review","volume":"35","author":"Park","year":"2010","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.identj.2023.07.008","article-title":"Advances in Regenerative Dentistry Approaches: An Update","volume":"74","author":"Thalakiriyawa","year":"2024","journal-title":"Int. Dent. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/edt.12762","article-title":"Tooth resorption-Part 2: A clinical classification","volume":"38","author":"Abbott","year":"2022","journal-title":"Dent. Traumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/edt.12495","article-title":"Long-term outcomes of autotransplantation of teeth: A case series","volume":"35","author":"Tsukiboshi","year":"2019","journal-title":"Dent. Traumatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/iej.13976","article-title":"Pathogenesis of non-infection related inflammatory root resorption in permanent teeth: A narrative review","volume":"56","author":"Lin","year":"2023","journal-title":"Int. Endod. J."},{"key":"ref_22","first-page":"515","article-title":"Root resorption of dental and traumatic origin: Classification based on etiology","volume":"10","author":"Trope","year":"1998","journal-title":"Pract. Periodontics Aesthet. Dent."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1034\/j.1600-9657.2003.00192.x","article-title":"Root resorption\u2014Diagnosis, classification and treatment choices based on stimulation factors","volume":"19","author":"Fuss","year":"2003","journal-title":"Dent. Traumatol."},{"key":"ref_24","first-page":"2","article-title":"Invasive Cervical Root Resorption: A Comprehensive Review on Pathogenesis, Diagnosis, and Treatment","volume":"19","author":"Asgary","year":"2024","journal-title":"Iran. Endod. J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kitaura, H., Marahleh, A., Ohori, F., Noguchi, T., Shen, W.R., Qi, J., Nara, Y., Pramusita, A., Kinjo, R., and Mizoguchi, I. (2020). Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145169"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/edt.12819","article-title":"A step-by step guide for autotransplantation of teeth","volume":"39","author":"Tsukiboshi","year":"2023","journal-title":"Dent. Traumatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.adaj.2024.01.006","article-title":"Advancements in tooth autotransplantation","volume":"155","author":"Dokova","year":"2024","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/cap.10272","article-title":"Translational approach to tooth autotransplantation: A 27-year case study","volume":"14","author":"Franceschi","year":"2024","journal-title":"Clin. Adv. Periodontics"},{"key":"ref_29","first-page":"e66904","article-title":"From Concept to Clinical Practice: A Review of Autotransplantation Techniques and Their Impact on Dentistry","volume":"16","author":"Ajay","year":"2024","journal-title":"Cureus"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.joms.2017.03.049","article-title":"Do Autotransplanted Teeth Require Elective Root Canal Therapy? A Long-Term Follow-Up Case Series","volume":"75","author":"Murtadha","year":"2017","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.joen.2025.02.003","article-title":"Nine-year Follow-up of Autotransplantation in the Maxillary Anterior Region: Replacing a Fused Incisor with a Supernumerary Tooth","volume":"51","author":"Sezer","year":"2025","journal-title":"J. Endod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e15336","DOI":"10.1016\/j.heliyon.2023.e15336","article-title":"Tooth autotransplantation gives teeth a second chance at life: A case series","volume":"9","author":"Ji","year":"2023","journal-title":"Heliyon"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S2168","DOI":"10.4103\/jpbs.jpbs_66_24","article-title":"Autogenic Molar Transplantation of Third Molar with Complete Root Formation Versus Incomplete Root Formation: A Prospective Clinical Study","volume":"16","author":"Dixit","year":"2024","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/edt.12351","article-title":"Effects of tooth storage media on periodontal ligament preservation","volume":"33","author":"Hasan","year":"2017","journal-title":"Dent. Traumatol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Fagundes, N.C.F., Bittencourt, L.O., Magno, M.B., Marques, M.M., Maia, L.C., and Lima, R.R. (2018). Efficacy of Hank\u2019s balanced salt solution compared to other solutions in the preservation of the periodontal ligament. A systematic review and meta-analysis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0209867"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1600-9657.2010.00879.x","article-title":"Study of the effectiveness of propolis extract as a storage medium for avulsed teeth","volume":"26","author":"Casaroto","year":"2010","journal-title":"Dent. Traumatol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Baxmann, M., Huth, K.C., K\u00e1rp\u00e1ti, K., and Bar\u00e1th, Z. (2025). Autogenous Transplantation of Teeth Across Clinical Indications: A Systematic Review and Meta-Analysis. J. Clin. Med., 14.","DOI":"10.3390\/jcm14145126"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Chhana, A.A., Moretti, A.J., Lietzan, A.D., Christensen, J.R., and Miguez, P.A. (2025). A Narrative and Case-Illustrated Review on Dental Autotransplantation Identifying Current Gaps in Knowledge. J. Clin. Med., 14.","DOI":"10.3390\/jcm14010017"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e7721","DOI":"10.1002\/ccr3.7721","article-title":"Successful outcome of permanent maxillary incisor reimplanted after 30\u2009hours of extra-oral time-a case report with 5-year follow-up","volume":"11","author":"Kaur","year":"2023","journal-title":"Clin. Case Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41368-024-00337-5","article-title":"Expert consensus on intentional tooth replantation","volume":"17","author":"Lin","year":"2025","journal-title":"Int. J. Oral. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13287-022-02700-x","article-title":"A new direction in managing avulsed teeth: Stem cell-based de novo PDL regeneration","volume":"13","author":"Aksel","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e70581","DOI":"10.1002\/ccr3.70581","article-title":"Immediate Autotransplantation of Mature Third Molars to Bilateral Mandibular First Molars With Large Periapical Lesions: A Case Report","volume":"13","author":"Ainiwaer","year":"2025","journal-title":"Clin. Case Rep."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Walch, B., Gaggl, A., Zeman-Kuhnert, K., and Brandtner, C. (2025). Autotransplantation of Impacted Third Molars to DCIA Free Flap in Adolescent Patient: A Case Report. Children, 12.","DOI":"10.3390\/children12030370"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Sartoretto, S.C., Shibli, J.A., Javid, K., Cotrim, K., Canabarro, A., Louro, R.S., Lowenstein, A., Mour\u00e3o, C.F., and Moraschini, V. (2023). Comparing the Long-Term Success Rates of Tooth Preservation and Dental Implants: A Critical Review. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14030142"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/edt.13012","article-title":"Clinical Efficacy of CBCT and 3D-Printed Replicas in Molar Autotransplantation: A Controlled Clinical Trial","volume":"41","author":"Lejnieks","year":"2025","journal-title":"Dent. Traumatol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Im, J., Kim, J.Y., Yu, H.S., Lee, K.J., Choi, S.H., Kim, J.H., Ahn, H.K., and Cha, J.Y. (2022). Accuracy and efficiency of automatic tooth segmentation in digital dental models using deep learning. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-13595-2"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Adamska, P., Pyli\u0144ska-D\u0105browska, D., Stasiak, M., Sobczak-Zagalska, H., Jusyk, A., Zedler, A., and Studniarek, M. (2024). Tooth Autotransplantation, Autogenous Dentin Graft, and Growth Factors Application: A Method for Preserving the Alveolar Ridge in Cases of Severe Infraocclusion\u2014A Case Report and Literature Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13133902"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6249\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:39:26Z","timestamp":1760035166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/17\/6249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":47,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcm14176249"],"URL":"https:\/\/doi.org\/10.3390\/jcm14176249","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]}}}