{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:01:03Z","timestamp":1772658063130,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In patients with cystic fibrosis (CF), infertility is a common issue in men, while women often experience subfertility. The introduction of CF transmembrane conductance regulator (CFTR) modulators has improved disease progression and enhanced quality of life, consequently leading to an increase in unplanned pregnancies. This article describes six cases of pregnancies in five patients diagnosed with severe CF who were treated with the combined therapy of elexacaftor\/tezacaftor\/ivacaftor (ETI). All women were under regular clinical and instrumental monitoring at the Regional CF Center for Adults at the University of Naples Federico II. The reported pregnancies were spontaneous, and all patients were followed throughout their pregnancies. Two pregnancies were carried to term by the same patient. All five patients with a severe CF phenotype were able to experience pregnancy without stopping their ETI treatment without any complications. In two cases, the patients chose to continue ETI therapy while breastfeeding, and there were no adverse events reported. A cesarean delivery was preferred in all cases to prevent potential respiratory distress. These five patients represent some of the few cases in Italy where pregnancy was achieved without interrupting treatment with ETI. However, the lack of more reliable data necessitates that doctors and patients carefully evaluate the risks and benefits of continuing or discontinuing treatment with CFTR modulators. In conclusion, the increasing number of pregnancies and the desire for children expressed by women with CF highlight the need for more data on the long-term effects of CFTR modulators.<\/jats:p>","DOI":"10.3390\/jcm14186520","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:59:51Z","timestamp":1758088791000},"page":"6520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Series on the Combined Therapy with Elexacaftor\/Tezacaftor\/Ivacaftor During Pregnancy in Women with Severe Cystic Fibrosis: A Retrospective Report from an Italian Centre"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8909-9726","authenticated-orcid":false,"given":"Paola","family":"Iacotucci","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8099-2072","authenticated-orcid":false,"given":"Jolanda","family":"Somma","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4702-7186","authenticated-orcid":false,"given":"Lorenza","family":"Ferrillo","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta","family":"Celardo","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-2739","authenticated-orcid":false,"given":"Valeria","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Scuola Medica Salernitana, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino Di","family":"Carlo","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9701-0437","authenticated-orcid":false,"given":"Giuseppe","family":"Rengo","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3441-889X","authenticated-orcid":false,"given":"Graziamaria","family":"Corbi","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-6883","authenticated-orcid":false,"given":"Vincenzo","family":"Carnovale","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1001\/jama.2023.8120","article-title":"Cystic Fibrosis: A Review","volume":"329","author":"Ong","year":"2023","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3390\/jcm13020585","article-title":"Cystic Fibrosis in Adults: A Paradigm of Frailty Syndrome? An Observational Study.","volume":"13","author":"Iacotucci","year":"2024","journal-title":"J. Clin. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.21037\/tau.2020.04.05","article-title":"Genetics of CFTR and male infertility","volume":"10","author":"Bieniek","year":"2021","journal-title":"Transl. Androl. Urol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/adc.87.2.135","article-title":"Urogenital abnormalities in male children with cystic fibrosis","volume":"87","author":"Blau","year":"2002","journal-title":"Arch. Dis. Child."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jcf.2018.10.009","article-title":"Failure to conceive in women with CF is associated with pancreatic insufficiency and advancing age","volume":"18","author":"Shteinberg","year":"2019","journal-title":"J. Cyst. Fibros."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jcf.2023.03.013","article-title":"Cervical mucus quality in females with and without cystic fibrosis","volume":"22","author":"Roe","year":"2023","journal-title":"J. Cyst. Fibros."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Jain, R., and Taylor-Cousar, J.L. (2021). Fertility, Pregnancy and Lactation Considerations for Women with CF in the CFTR Modulator Era. J. Pers. Med., 11.","DOI":"10.3390\/jpm11050418"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s00404-023-07153-y","article-title":"Unplanned pregnancies following the introduction of elexacaftor\/tezacaftor\/ivacaftor therapy in women with cystic fibrosis","volume":"308","author":"Alicandro","year":"2023","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jcf.2020.02.018","article-title":"Outcomes of pregnancy in women with cystic fibrosis (CF) taking CFTR modulators\u2014an international survey","volume":"19","author":"Nash","year":"2020","journal-title":"J. Cyst. Fibros."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Li, D., Zhu, Y., Donnelley, M., Parsons, D., Habgood, M.D., and Schneider-Futschik, E.K. (2024). Fetal drug exposure after maternally administered CFTR modulators Elexacaftor\/Tezacaftor\/Ivacaftor in a rat model. Biomed. Pharmacother., 171.","DOI":"10.1016\/j.biopha.2024.116155"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jcf.2024.11.014","article-title":"Lens-related ocular changes in fetal rats following in-utero exposure to elexacaftor-tezacaftor-ivacaftor","volume":"24","author":"Zhu","year":"2025","journal-title":"J. Cyst. Fibros."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1111\/bph.16417","article-title":"Extent of foetal exposure to maternal elexacaftor\/tezacaftor\/ivacaftor during pregnancy","volume":"181","author":"Li","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","article-title":"Cystic fibrosis","volume":"388","author":"Elborn","year":"2016","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE guidelines for case reports: Explanation and elaboration document","volume":"89","author":"Riley","year":"2017","journal-title":"J. Clin. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jcf.2014.09.008","article-title":"Cystic fibrosis (CF) and ovarian reserve: A cross-sectional study examining serum anti-mullerian hormone (amh) in young women","volume":"14","author":"Schram","year":"2015","journal-title":"J. Cyst. Fibros."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-med-042921-021447","article-title":"Cystic Fibrosis Modulator Therapies","volume":"74","author":"Jia","year":"2023","journal-title":"Annu. Rev. Med."},{"key":"ref_17","first-page":"101637","article-title":"Update on advances in cystic fibrosis towards a cure and implications for primary care clinicians","volume":"54","author":"Terlizzi","year":"2024","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Carnovale, V., Iacotucci, P., Terlizzi, V., Colangelo, C., Ferrillo, L., Pepe, A., Francalanci, M., Taccetti, G., Buonaurio, S., and Celardo, A. (2022). Elexacaftor\/Tezacaftor\/Ivacaftor in Patients with Cystic Fibrosis Homozygous for the F508del Mutation and Advanced Lung Disease: A 48-Week Observational Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11041021"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jcf.2017.01.008","article-title":"Pregnancy among cystic fibrosis women in the era of CFTR modulators","volume":"16","author":"Heltshe","year":"2017","journal-title":"J. Cyst. Fibros."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jcf.2020.12.011","article-title":"Elexacafator\/tezacaftor\/ivacaftor resolves subfertility in females with CF: A two center case series","volume":"20","author":"Goodwin","year":"2021","journal-title":"J. Cyst. Fibros."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jcf.2022.10.004","article-title":"Congenital bilateral cataracts in newborns exposed to elexacaftor-tezacaftor-ivacaftor in utero and while breast feeding","volume":"21","author":"Jain","year":"2022","journal-title":"J. Cyst. Fibros."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ripani, P., Mucci, M., Pantano, S., Di Sabatino, M., Collini, F., Ferri, G., Romano, M., and Recchiuti, A. (2023). Maternal, newborn and breast milk concentrations of elexacaftor\/tezacaftor\/ivacaftor in a F508del heterozygous woman with cystic fibrosis following successful pregnancy. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1274303"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jcf.2024.05.007","article-title":"Standards for the care of people with cystic fibrosis (CF); Planning for a longer life","volume":"23","author":"Gramegna","year":"2024","journal-title":"J. Cyst. Fibros."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1901208","DOI":"10.1183\/13993003.01208-2019","article-title":"ERS\/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases","volume":"55","author":"Middleton","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1016\/j.jcf.2019.12.004","article-title":"To be or not to be on CFTR modulators during pregnancy: Risks to be considered","volume":"19","author":"Vekaria","year":"2020","journal-title":"J. Cyst. Fibros."},{"key":"ref_26","first-page":"101778","article-title":"Experience to date with CFTR modulators during pregnancy and breastfeeding in the British Columbia Cystic Fibrosis clinic","volume":"40","author":"Goodwin","year":"2022","journal-title":"Respir. Med. Case Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100340","DOI":"10.1016\/j.clinme.2025.100340","article-title":"A descriptive cohort study of pregnancy and parenthood in women with cystic fibrosis","volume":"25","author":"Duffy","year":"2025","journal-title":"Clin. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.chest.2024.09.019","article-title":"Impact of Cystic Fibrosis Transmembrane Conductance Regulator Modulators on Maternal Outcomes During and After Pregnancy","volume":"167","author":"Jain","year":"2025","journal-title":"Chest"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e001289","DOI":"10.1136\/bmjresp-2022-001289","article-title":"Prospectively evaluating maternal and fetal outcomes in the era of CFTR modulators: The MAYFLOWERS observational clinical trial study design","volume":"9","author":"Jain","year":"2022","journal-title":"BMJ Open Respir. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jcf.2007.10.001","article-title":"European Cystic Fibrosis Society. Guidelines for the management of pregnancy in women with cystic fibrosis","volume":"7","author":"Edenborough","year":"2008","journal-title":"J. Cyst. Fibros."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.rmed.2018.11.009","article-title":"A case-control study on pregnancy in Italian Cystic Fibrosis women. Data from the Italian Registry","volume":"145","author":"Giordani","year":"2018","journal-title":"Respir. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ccm.2021.04.008","article-title":"Pulmonary Considerations for Pregnant Women","volume":"42","author":"Nassikas","year":"2021","journal-title":"Clin. Chest Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.arcped.2025.03.005","article-title":"Preliminary proposals for the follow-up of infants born to mothers with cystic fibrosis treated with CFTR modulators during the first two years of life","volume":"32","author":"Reix","year":"2025","journal-title":"Arch. Pediatr."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/18\/6520\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:46:43Z","timestamp":1760035603000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/18\/6520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":33,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcm14186520"],"URL":"https:\/\/doi.org\/10.3390\/jcm14186520","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,16]]}}}