{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:10:07Z","timestamp":1792030207134,"version":"4.4.0"},"reference-count":155,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Obstructive sleep apnea syndrome (OSAS) and impaired nasal breathing are common in children and are frequently linked to maxillary constriction. Rapid maxillary expansion (RME) is an orthopedic treatment used to increase upper airway dimensions and improve respiratory function. It has been hypothesized that RME could contribute to improvements in behavior and cognition, possibly through enhanced sleep and respiratory function. It also promotes the shift from oral to nasal breathing, supporting craniofacial development and neuromuscular stability, and it is increasingly recognized as a multidisciplinary intervention that can improve pediatric health outcomes. With increasing evidence supporting its efficacy, RME should be considered not only for its orthodontic benefits but also as a multidisciplinary treatment option within pediatric care protocols. This underscores the importance of integrated care among orthodontists, ENT specialists, and pediatricians. Aim: To systematically assess the impact of RME on nasal respiratory parameters and sleep-disordered breathing, particularly OSAS, in pediatric patients. Methods: Following PRISMA guidelines, a systematic review was conducted using 12 clinical studies evaluating anatomical and functional respiratory changes after RME in children with mouth breathing or OSAS. Parameters included airway volume (CBCT, cephalometry), nasal resistance (rhinomanometry), and polysomnography (PSG) data. Results: RME consistently resulted in significant increases in nasal cavity volume and upper airway dimensions. Multiple studies reported reductions in the apnea\u2013hypopnea index (AHI), improved oxygen saturation, and better subjective sleep quality. Longitudinal studies confirmed the stability of these benefits. However, variability in study protocols limited meta-analytical comparison. Conclusions: RME is effective in enhancing nasal breathing and mitigating OSAS symptoms in children. While results are promising, further high-quality randomized controlled trials are needed to validate these findings and guide standardized treatment protocols.<\/jats:p>","DOI":"10.3390\/jcm14186565","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:54:26Z","timestamp":1758200066000},"page":"6565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of the Effect of Rapid Maxillary Expansion on Nasal Respiratory Function and Obstructive Sleep Apnea Syndrome in Children: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-1039","authenticated-orcid":false,"given":"Alessio Danilo","family":"Inchingolo","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-2350","authenticated-orcid":false,"given":"Grazia","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirka","family":"Cavino","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6686-3104","authenticated-orcid":false,"given":"Lucia Pia","family":"Zaminga","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Savastano","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-5883","authenticated-orcid":false,"given":"Francesco","family":"Inchingolo","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca Martino","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Science, Milan University, 20122 Milan, Italy"},{"name":"Unit of Maxillo-Facial Surgery and Dentistry, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-0984","authenticated-orcid":false,"given":"Massimo","family":"Del Fabbro","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Science, Milan University, 20122 Milan, Italy"},{"name":"Unit of Maxillo-Facial Surgery and Dentistry, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Palermo","sequence":"additional","affiliation":[{"name":"Department of Experiment Medicine, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-6337","authenticated-orcid":false,"given":"Angelo Michele","family":"Inchingolo","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-8987","authenticated-orcid":false,"given":"Gianna","family":"Dipalma","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Abate, A., Lanteri, V., Marcolongo, L., Solimei, L., and Maspero, C. (2023). Evaluation of Masticatory Muscles in Adult Patients with Maxillary Hypoplasia Treated with Surgically Assisted Rapid Maxillary Expansion (SARME): A Retrospective Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12020607"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bjorl.2017.01.009","article-title":"Rapid Maxillary Expansion in Mouth Breathers: A Short-Term Skeletal and Soft-Tissue Effect on the Nose","volume":"84","author":"Badreddine","year":"2018","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_3","first-page":"617","article-title":"Rapid Maxillary Expansion and Upper Airway Volume: Systematic Review and Meta-Analysis on the Role of Rapid Maxillary Expansion in Mouth Breathing","volume":"15","author":"Balasubramanian","year":"2022","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1590\/2176-9451.19.5.079-087.oar","article-title":"Transverse Effects on the Nasomaxillary Complex One Year after Rapid Maxillary Expansion as the Only Intervention: A Controlled Study","volume":"19","author":"Baratieri","year":"2014","journal-title":"Dent. Press J. Orthod."},{"key":"ref_5","first-page":"118","article-title":"Does the Timing and Method of Rapid Maxillary Expansion Have an Effect on the Changes in Nasal Dimensions?","volume":"72","author":"Basciftci","year":"2002","journal-title":"Angle Orthod."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Cerkezi, S., Nakova, M., Gorgoski, I., Ferati, K., Bexheti-Ferati, A., Palermo, A., Inchingolo, A.D., Ferrante, L., Inchingolo, A.M., and Inchingolo, F. (2024). The Role of Sulfhydryl (Thiols) Groups in Oral and Periodontal Diseases. Biomedicines, 12.","DOI":"10.3390\/biomedicines12040882"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Dipalma, G., Inchingolo, A.D., Mem\u00e8, L., Casamassima, L., Carone, C., Malcangi, G., Inchingolo, F., Palermo, A., and Inchingolo, A.M. (2024). The Diagnosis and Management of Infraoccluded Deciduous Molars: A Systematic Review. Children, 11.","DOI":"10.3390\/children11111375"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Dipalma, G., Inchingolo, A.M., Latini, G., Ferrante, L., Nardelli, P., Malcangi, G., Trilli, I., Inchingolo, F., Palermo, A., and Inchingolo, A.D. (2024). The Effectiveness of Curcumin in Treating Oral Mucositis Related to Radiation and Chemotherapy: A Systematic Review. Antioxidants, 13.","DOI":"10.3390\/antiox13101160"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.D., Ferrara, I., Viapiano, F., Netti, A., Campanelli, M., Buongiorno, S., Latini, G., Carpentiere, V., Ciocia, A.M., and Ceci, S. (2022). Rapid Maxillary Expansion on the Adolescent Patient: Systematic Review and Case Report. Children, 9.","DOI":"10.3390\/children9071046"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.D., Inchingolo, A.M., Malcangi, G., Avantario, P., Azzollini, D., Buongiorno, S., Viapiano, F., Campanelli, M., Ciocia, A.M., and De Leonardis, N. (2022). Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism\u2014A Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14173519"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1111\/joor.13574","article-title":"Occurrence of Temporomandibular Disorders among Patients Undergoing Treatment for Obstructive Sleep Apnoea Syndrome (OSAS) Using Mandibular Advancement Device (MAD): A Systematic Review Conducted According to PRISMA Guidelines and the Cochrane Handbook for Systematic Reviews of Interventions","volume":"50","author":"Langaliya","year":"2023","journal-title":"J. Oral Rehabil."},{"key":"ref_12","first-page":"67","article-title":"A Hygienic Appliance for Rapid Expansion","volume":"2","author":"Biederman","year":"1968","journal-title":"JPO J. Pract. Orthod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0889-5406(87)90202-2","article-title":"Maxillary Expansion: Clinical Implications","volume":"91","author":"Bishara","year":"1987","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.joms.2015.11.035","article-title":"Effect of Surgically Assisted Rapid Maxillary Expansion on Upper Airway Volume: A Systematic Review","volume":"74","author":"Buck","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/2177-6709.25.3.039-045.oar","article-title":"Effect of Rapid Maxillary Expansion on Nasal Cavity Assessed with Cone-Beam Computed Tomography","volume":"25","author":"Caldas","year":"2020","journal-title":"Dent. Press J. Orthod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1067\/mod.2002.120685","article-title":"Long-Term Effects of Rapid Maxillary Expansion: A Posteroanterior Cephalometric Evaluation","volume":"121","author":"Cameron","year":"2002","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_17","first-page":"2089","article-title":"CHARGE Syndrome: An Overview on Dental and Maxillofacial Features","volume":"18","author":"Inchingolo","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.M., Patano, A., De Santis, M., Del Vecchio, G., Ferrante, L., Morolla, R., Pezzolla, C., Sardano, R., Dongiovanni, L., and Inchingolo, F. (2023). Comparison of Different Types of Palatal Expanders: Scoping Review. Children, 10.","DOI":"10.3390\/children10071258"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.M., Inchingolo, A.D., Viapiano, F., Ciocia, A.M., Ferrara, I., Netti, A., Dipalma, G., Palermo, A., and Inchingolo, F. (2023). Treatment Approaches to Molar Incisor Hypomineralization: A Systematic Review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12227194"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.M., Inchingolo, A.D., Trilli, I., Ferrante, L., Di Noia, A., de Ruvo, E., Palermo, A., Inchingolo, F., and Dipalma, G. (2024). Orthopedic Devices for Skeletal Class III Malocclusion Treatment in Growing Patients: A Comparative Effectiveness Systematic Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13237141"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.M., Inchingolo, A.D., Nardelli, P., Latini, G., Trilli, I., Ferrante, L., Malcangi, G., Palermo, A., Inchingolo, F., and Dipalma, G. (2024). Stem Cells: Present Understanding and Prospects for Regenerative Dentistry. J. Funct. Biomater., 15.","DOI":"10.3390\/jfb15100308"},{"key":"ref_22","first-page":"e241","article-title":"Expansion of Permanent First Molars with Rapid Maxillary Expansion Appliance Anchored on Primary Second Molars","volume":"10","author":"Tepedino","year":"2018","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_23","first-page":"59","article-title":"Breathing Pattern and Head Posture: Changes in Craniocervical Angles","volume":"64","author":"Sabatucci","year":"2015","journal-title":"Minerva Stomatol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Dipalma, G., Inchingolo, A.D., Pezzolla, C., Sardano, R., Trilli, I., Di Venere, D., Corsalini, M., Inchingolo, F., Severino, M., and Palermo, A. (2025). Head and Cervical Posture in Sagittal Skeletal Malocclusions: Insights from a Systematic Review. J. Clin. Med., 14.","DOI":"10.3390\/jcm14082626"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Inchingolo, F., Hazballa, D., Inchingolo, A.D., Malcangi, G., Marinelli, G., Mancini, A., Maggiore, M.E., Bordea, I.R., Scarano, A., and Farronato, M. (2022). Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review. Materials, 15.","DOI":"10.3390\/ma15031120"},{"key":"ref_26","first-page":"25","article-title":"Unilateral Posterior Crossbite in Adolescents: Surface Electromyographic Evaluation","volume":"13","author":"Ciavarella","year":"2012","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajodo.2017.11.033","article-title":"Midfacial Changes in the Coronal Plane Induced by Microimplant-Supported Skeletal Expander, Studied with Cone-Beam Computed Tomography Images","volume":"154","author":"Cantarella","year":"2018","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cerritelli, L., Hatzopoulos, S., Catalano, A., Bianchini, C., Cammaroto, G., Meccariello, G., Iannella, G., Vicini, C., Pelucchi, S., and Skarzynski, P.H. (2022). Rapid Maxillary Expansion (RME): An Otolaryngologic Perspective. J. Clin. Med., 11.","DOI":"10.3390\/jcm11175243"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ajodo.2012.11.019","article-title":"Dimensional Changes of Upper Airway after Rapid Maxillary Expansion: A Prospective Cone-Beam Computed Tomography Study","volume":"143","author":"Chang","year":"2013","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1067\/mod.2001.110167","article-title":"A Comparison of Dental and Dentoalveolar Changes between Rapid Palatal Expansion and Nickel-Titanium Palatal Expansion Appliances","volume":"119","author":"Ciambotti","year":"2001","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40510-020-00321-9","article-title":"Tomographic Assessment of Palatal Suture Opening Pattern and Pterygopalatine Suture Disarticulation in the Axial Plane after Midfacial Skeletal Expansion","volume":"21","author":"Colak","year":"2020","journal-title":"Prog. Orthod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/ejo\/22.5.519","article-title":"Effect of Rapid Maxillary Expansion on Skeletal, Dental, and Nasal Structures: A Postero-Anterior Cephalometric Study","volume":"22","author":"Cross","year":"2000","journal-title":"Eur. J. Orthod."},{"key":"ref_33","first-page":"S175","article-title":"The key role of the palatal expander in orthodontics","volume":"13","author":"Bambini","year":"2024","journal-title":"Eur. J. Musculoskelet. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1758-3284-3-1","article-title":"Non-Hodgkin Lymphoma Affecting the Tongue: Unusual Intra-Oral Location","volume":"3","author":"Inchingolo","year":"2011","journal-title":"Head Neck Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Limongelli, L., Cascardi, E., Capodiferro, S., Favia, G., Corsalini, M., Tempesta, A., and Maiorano, E. (2020). Multifocal Amelanotic Melanoma of the Hard Palate: A Challenging Case. Diagnostics, 10.","DOI":"10.3390\/diagnostics10060424"},{"key":"ref_36","first-page":"7653","article-title":"New Biograft Solution, Growth Factors and Bone Regenerative Approaches in Neurosurgery, Dentistry, and Orthopedics: A Review","volume":"27","author":"Montemurro","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kang, J.-H., Kim, H.J., and Song, S.I. (2022). Obstructive Sleep Apnea and Anatomical Structures of the Nasomaxillary Complex in Adolescents. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0272262"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11325-005-0028-8","article-title":"Orthodontic Treatment in Children to Prevent Sleep-Disordered Breathing in Adulthood","volume":"9","author":"Kikuchi","year":"2005","journal-title":"Sleep Breath."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1164\/ajrccm.153.3.8630569","article-title":"Upper Airway Shape: Is It Important in the Pathogenesis of Obstructive Sleep Apnea?","volume":"153","author":"Leiter","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_40","first-page":"666","article-title":"Oropharyngeal Collapse Predicts Treatment Response with Oral Appliance Therapy in Obstructive Sleep Apnea","volume":"29","author":"Ng","year":"2006","journal-title":"Sleep"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The Epidemiology of Adult Obstructive Sleep Apnea","volume":"5","author":"Punjabi","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"key":"ref_42","first-page":"2840","article-title":"Obstructive sleep apnea syndrome. Current literature on diagnostic methods","volume":"91","author":"Svanborg","year":"1994","journal-title":"Lakartidningen"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1054\/jcms.2000.0147","article-title":"Obstructive Sleep Apnoea: Multiple Comparisons of Cephalometric Variables of Obese and Non-Obese Patients","volume":"28","author":"Tangugsorn","year":"2000","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1001\/jama.289.17.2230","article-title":"Incidence of Sleep-Disordered Breathing in an Urban Adult Population: The Relative Importance of Risk Factors in the Development of Sleep-Disordered Breathing","volume":"289","author":"Tishler","year":"2003","journal-title":"JAMA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ajodo.2011.08.025","article-title":"Improvement of Nasal Airway Ventilation after Rapid Maxillary Expansion Evaluated with Computational Fluid Dynamics","volume":"141","author":"Iwasaki","year":"2012","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ajodo.2012.09.014","article-title":"Tongue Posture Improvement and Pharyngeal Airway Enlargement as Secondary Effects of Rapid Maxillary Expansion: A Cone-Beam Computed Tomography Study","volume":"143","author":"Iwasaki","year":"2013","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1046\/j.1365-2273.2003.00722.x","article-title":"The Association of Subjective Nasal Patency with Peak Inspiratory Nasal Flow in a Large Healthy Population","volume":"28","author":"Jose","year":"2003","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"ref_48","first-page":"1","article-title":"Nasal Airway Changes in Bone-Borne and Tooth-Borne Rapid Maxillary Expansion Treatments","volume":"13","author":"Kabalan","year":"2015","journal-title":"Int. Orthod."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1097\/SCS.0000000000003008","article-title":"Evaluation of Sleep Quality in Patients with Nasal Septal Deviation via the Pittsburgh Sleep Quality Index","volume":"27","author":"Kara","year":"2016","journal-title":"J. Craniofac. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.ijporl.2008.07.014","article-title":"Effects of Rapid Maxillary Expansion on Nasal Breathing and Some Naso-Respiratory and Breathing Problems in Growing Children: A Literature Review","volume":"72","author":"Oktay","year":"2008","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_51","unstructured":"(2025, May 24). Variation in Symptoms of Sleep-Disordered Breathing with Race and Ethnicity: The Sleep Heart Health Study, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/12627736\/."},{"key":"ref_52","unstructured":"(2025, May 24). Sleep-Disordered Breathing, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/23099131\/."},{"key":"ref_53","unstructured":"(2025, May 24). Predictors of Sleep-Disordered Breathing in Community-Dwelling Adults: The Sleep Heart Health Study, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/11966340\/."},{"key":"ref_54","unstructured":"(2025, May 24). Mandibular Advancement Devices in 630 Men and Women with Obstructive Sleep Apnea and Snoring: Tolerability and Predictors of Treatment Success, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/15078734\/."},{"key":"ref_55","unstructured":"(2025, May 24). Heart Rate Responses to Autonomic Challenges in Obstructive Sleep Apnea, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/24194842\/."},{"key":"ref_56","first-page":"45","article-title":"Comparison of the Dental and Skeletal Effects of Two Different Rapid Palatal Expansion Appliances for the Correction of the Maxillary Asymmetric Transverse Discrepancies","volume":"61","author":"Farronato","year":"2012","journal-title":"Minerva Stomatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/ejo\/cjq051","article-title":"Rapid Maxillary Expansion in Growing Patients. Hyrax versus Transverse Sagittal Maxillary Expander: A Cephalometric Investigation","volume":"33","author":"Farronato","year":"2011","journal-title":"Eur. J. Orthod."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"100845","DOI":"10.1016\/j.ortho.2024.100845","article-title":"Divergence between CBCT and Optical Scans for Soft Tissue Analysis and Cephalometry in Facial Imaging: A Cross-Sectional Study on Healthy Adults","volume":"22","author":"Farronato","year":"2024","journal-title":"Int. Orthod."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Maspero, C., Cenzato, N., Inchingolo, F., Cagetti, M.G., Isola, G., Sozzi, D., Del Fabbro, M., and Tartaglia, G.M. (2023). The Maxilla-Mandibular Discrepancies through Soft-Tissue References: Reliability and Validation of the Anteroposterior Measurement. Children, 10.","DOI":"10.3390\/children10030459"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lanteri, V., Farronato, M., Ugolini, A., Cossellu, G., Gaffuri, F., Parisi, F.M.R., Cavagnetto, D., Abate, A., and Maspero, C. (2020). Volumetric Changes in the Upper Airways after Rapid and Slow Maxillary Expansion in Growing Patients: A Case-Control Study. Materials, 13.","DOI":"10.3390\/ma13102239"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1001\/jamafacial.2013.344","article-title":"Development of a Severity Classification System for Subjective Nasal Obstruction","volume":"15","author":"Lipan","year":"2013","journal-title":"JAMA Facial Plast. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ajodo.2010.11.024","article-title":"Nasal Cavity Size, Airway Resistance, and Subjective Sensation after Surgically Assisted Rapid Maxillary Expansion: A Prospective Longitudinal Study","volume":"140","author":"Magnusson","year":"2011","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_63","first-page":"e769","article-title":"Effect of Rapid Maxillary Expansion on the Apnoea-Hypopnoea Index during Sleep in Children","volume":"14","year":"2022","journal-title":"Syst. Rev. J. Clin. Exp. Dent."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40510-015-0105-x","article-title":"The Role of Rapid Maxillary Expansion in the Promotion of Oral and General Health","volume":"16","author":"McNamara","year":"2015","journal-title":"Prog. Orthod."},{"key":"ref_65","unstructured":"Melsen, B. (1972). A Histological Study of the Influence of Sutural Morphology and Skeletal Maturation on Rapid Palatal Expansion in Children. Trans. Eur. Orthod. Soc., 499\u2013507."},{"key":"ref_66","first-page":"215","article-title":"Rapid Expansion of the Maxillary Arch. II. Indications for Rapid Expansion","volume":"2","author":"Moss","year":"1968","journal-title":"JPO J. Pract. Orthod."},{"key":"ref_67","unstructured":"(2025, May 24). Adult Sleep Apnea Syndromes, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/7653425\/."},{"key":"ref_68","unstructured":"(2025, May 24). A Randomized, Controlled Study of a Mandibular Advancement Splint for Obstructive Sleep Apnea, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/11371418\/."},{"key":"ref_69","unstructured":"(2025, May 24). A Four Year Follow-Up of Sleep and Respiratory Measures in Elementary School-Aged Children with Sleep Disordered Breathing, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/23499429\/."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"(2025, May 28). Therapeutic and Adverse Effects of Lasers in Dentistry: A Systematic Review. Available online: https:\/\/www.mdpi.com\/2304-6732\/10\/6\/650.","DOI":"10.3390\/photonics10060650"},{"key":"ref_71","unstructured":"(2025, May 28). Rapid Palate Expansion\u2019s Impact on Nasal Breathing: A Systematic Review, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/39954405\/."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/jama.283.14.1829","article-title":"Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Study. Sleep Heart Health Study","volume":"283","author":"Nieto","year":"2000","journal-title":"JAMA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ajodo.2006.10.034","article-title":"Relationship between Rapid Maxillary Expansion and Nasal Cavity Size and Airway Resistance: Short- and Long-Term Effects","volume":"134","author":"Viana","year":"2008","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ajodo.2005.10.025","article-title":"Use of Conventional Tomography to Evaluate Changes in the Nasal Cavity with Rapid Palatal Expansion","volume":"132","author":"Palaisa","year":"2007","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ijom.2013.11.002","article-title":"Volumetric Upper Airway Assessment in Patients with Transverse Maxillary Deficiency after Surgically Assisted Rapid Maxillary Expansion","volume":"43","author":"Monnazzi","year":"2014","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ajodo.2007.05.015","article-title":"Morphologic Changes of the Palate after Rapid Maxillary Expansion: A 3-Dimensional Computed Tomography Evaluation","volume":"134","author":"Phatouros","year":"2008","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_77","first-page":"67","article-title":"Proposal for a Myofunctional Therapy Protocol in Case of Altered Lingual Frenulum. A Pilot Study","volume":"20","author":"Saccomanno","year":"2019","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref_78","first-page":"243","article-title":"A Specific Protocol of Myo-Functional Therapy in Children with Down Syndrome. A Pilot Study","volume":"19","author":"Saccomanno","year":"2018","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref_79","unstructured":"(2025, May 28). Influence of Respiratory Pattern on Craniofacial Growth, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/6947703\/."},{"key":"ref_80","unstructured":"(2025, May 28). Nasal Involvement in Obstructive Sleep Apnea Syndrome, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/25548569\/."},{"key":"ref_81","unstructured":"(2025, May 28). Non-Surgical Treatment of Transverse Deficiency in Adults Using Microimplant-Assisted Rapid Palatal Expansion (MARPE), Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/28444019\/."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5624\/isd.2012.42.2.83","article-title":"Does Hyrax Expansion Therapy Affect Maxillary Sinus Volume? A Cone-Beam Computed Tomography Report","volume":"42","author":"Darsey","year":"2012","journal-title":"Imaging Sci. Dent."},{"key":"ref_83","first-page":"490.e1","article-title":"Long-Term Effects of Orthodontic Therapy on the Maxillary Dental Arch and Nasal Cavity","volume":"136","author":"Bhushan","year":"2009","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Di Carlo, G., Saccucci, M., Ierardo, G., Luzzi, V., Occasi, F., Zicari, A.M., Duse, M., and Polimeni, A. (2017). Rapid Maxillary Expansion and Upper Airway Morphology: A Systematic Review on the Role of Cone Beam Computed Tomography. Biomed. Res. Int., 2017.","DOI":"10.1155\/2017\/5460429"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1183\/13993003.00385-2015","article-title":"Obstructive Sleep Disordered Breathing in 2- to 18-Year-Old Children: Diagnosis and Management","volume":"47","author":"Kaditis","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1542\/peds.2012-1671","article-title":"Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome","volume":"130","author":"Marcus","year":"2012","journal-title":"Pediatrics"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4103\/0970-9290.94566","article-title":"Evaluation of Craniofacial Morphology in Patients with Obstructive Sleep Apnea Using Lateral Cephalometry and Dynamic MRI","volume":"22","author":"Bharadwaj","year":"2011","journal-title":"Indian J. Dent. Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Duan, J., Xia, W., Li, X., Zhang, F., Wang, F., Chen, M., Chen, Q., Wang, B., and Li, B. (2025). Airway Morphology, Hyoid Position, and Serum Inflammatory Markers of Obstructive Sleep Apnea in Children Treated with Modified Twin-Block Appliances. BMC Oral Health, 25.","DOI":"10.1186\/s12903-025-05528-y"},{"key":"ref_89","first-page":"67","article-title":"The Impact of Rapid Palatal Expansion on Children\u2019s General Health: A Literature Review","volume":"15","author":"Eichenberger","year":"2014","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40510-020-00342-4","article-title":"An Assessment of the Magnitude, Parallelism, and Asymmetry of Micro-Implant-Assisted Rapid Maxillary Expansion in Non-Growing Patients","volume":"21","author":"Elkenawy","year":"2020","journal-title":"Prog. Orthod."},{"key":"ref_91","first-page":"129","article-title":"Multimodal Airway Evaluation in Growing Patients after Rapid Maxillary Expansion","volume":"16","author":"Fastuca","year":"2015","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2319\/072014-504.1","article-title":"Airway Compartments Volume and Oxygen Saturation Changes after Rapid Maxillary Expansion: A Longitudinal Correlation Study","volume":"85","author":"Fastuca","year":"2015","journal-title":"Angle Orthod."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40510-014-0040-2","article-title":"Role of Mandibular Displacement and Airway Size in Improving Breathing after Rapid Maxillary Expansion","volume":"15","author":"Fastuca","year":"2014","journal-title":"Prog. Orthod."},{"key":"ref_94","first-page":"1311","article-title":"Obstructive Sleep Apnea Is a Common Disorder in the Population\u2014A Review on the Epidemiology of Sleep Apnea","volume":"7","author":"Franklin","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"ref_95","first-page":"231","article-title":"Orthodontic Treatment Timing in Growing Patients","volume":"14","author":"Grippaudo","year":"2013","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40510-018-0233-1","article-title":"Three-Dimensional Analysis of Dental Arch Forms in Italian Population","volume":"19","author":"Oliva","year":"2018","journal-title":"Prog. Orthod."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e511","DOI":"10.1016\/j.ajodo.2011.02.015","article-title":"Airway Volume for Different Dentofacial Skeletal Patterns","volume":"139","author":"El","year":"2011","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajodo.2008.06.004","article-title":"Skeletal Effects to the Maxilla after Rapid Maxillary Expansion Assessed with Cone-Beam Computed Tomography","volume":"134","author":"Garrett","year":"2008","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Georgiadis, T., Angelopoulos, C., Papadopoulos, M.A., and Kolokitha, O.-E. (2023). Three-Dimensional Cone-Beam Computed Tomography Evaluation of Changes in Naso-Maxillary Complex Associated with Rapid Palatal Expansion. Diagnostics, 13.","DOI":"10.3390\/diagnostics13071322"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40510-015-0085-x","article-title":"Computational Fluid Dynamics Analysis of the Upper Airway after Rapid Maxillary Expansion: A Case Report","volume":"16","author":"Ghoneima","year":"2015","journal-title":"Prog. Orthod."},{"key":"ref_101","first-page":"200","article-title":"The treatment of maxillary deficiency by opening the midpalatal suture","volume":"35","author":"Haas","year":"1965","journal-title":"Angle Orthod."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0002-9416(70)90241-1","article-title":"Palatal Expansion: Just the Beginning of Dentofacial Orthopedics","volume":"57","author":"Haas","year":"1970","journal-title":"Am. J. Orthod."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ajodo.2013.04.012","article-title":"Effects of Rapid Palatal Expansion on the Sagittal and Vertical Dimensions of the Maxilla: A Study on Cephalograms Derived from Cone-Beam Computed Tomography","volume":"144","author":"Habeeb","year":"2013","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ajodo.2008.03.020","article-title":"Morphologic Changes of the Nasal Cavity Induced by Rapid Maxillary Expansion: A Study on 3-Dimensional Computed Tomography Models","volume":"136","author":"Haralambidis","year":"2009","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e1258","DOI":"10.4317\/jced.58932","article-title":"Impact of Rapid Maxillary Expansion on Mouth-Breathing Children and Adolescents: A Systematic Review","volume":"13","author":"Sakai","year":"2021","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40510-019-0278-9","article-title":"Rapid Maxillary Expansion Outcomes According to Midpalatal Suture Maturation Levels","volume":"20","author":"Sayar","year":"2019","journal-title":"Prog. Orthod."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3889\/oamjms.2019.080","article-title":"Transverse Skeletal Effects of Rapid Maxillary Expansion in Pre and Post Pubertal Subjects: A Systematic Review","volume":"7","author":"Elkordy","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.ajodo.2011.12.017","article-title":"Three-Dimensional Computed Tomography Analysis of Airway Volume Changes after Rapid Maxillary Expansion","volume":"141","author":"Smith","year":"2012","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0889-5406(93)70073-W","article-title":"A Longitudinal Cephalometric Study of Transverse and Vertical Craniofacial Growth","volume":"104","author":"Snodell","year":"1993","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1007\/s00784-023-05207-8","article-title":"Volumetric Changes in the Upper Airway on CBCT after Dentofacial Orthopedic Interventions\u2014A Systematic Review","volume":"27","author":"Steegman","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Rapone, B., Inchingolo, A.D., Trasarti, S., Ferrara, E., Qorri, E., Mancini, A., Montemurro, N., Scarano, A., Inchingolo, A.M., and Dipalma, G. (2022). Long-Term Outcomes of Implants Placed in Maxillary Sinus Floor Augmentation with Porous Fluorohydroxyapatite (Algipore\u00ae FRIOS\u00ae) in Comparison with Anorganic Bovine Bone (Bio-Oss\u00ae) and Platelet Rich Plasma (PRP): A Retrospective Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092491"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Patano, A., Inchingolo, A.M., Cardarelli, F., Inchingolo, A.D., Viapiano, F., Giotta, M., Bartolomeo, N., Di Venere, D., Malcangi, G., and Minetti, E. (2023). Effects of Elastodontic Appliance on the Pharyngeal Airway Space in Class II Malocclusion. J. Clin. Med., 12.","DOI":"10.3390\/jcm12134280"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Minetti, E., Palermo, A., Malcangi, G., Inchingolo, A.D., Mancini, A., Dipalma, G., Inchingolo, F., Patano, A., and Inchingolo, A.M. (2023). Dentin, Dentin Graft, and Bone Graft: Microscopic and Spectroscopic Analysis. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14050272"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Malcangi, G., Patano, A., Palmieri, G., Di Pede, C., Latini, G., Inchingolo, A.D., Hazballa, D., de Ruvo, E., Garofoli, G., and Inchingolo, F. (2023). Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review. Cells, 12.","DOI":"10.3390\/cells12131797"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Malcangi, G., Patano, A., Ciocia, A.M., Netti, A., Viapiano, F., Palumbo, I., Trilli, I., Guglielmo, M., Inchingolo, A.D., and Dipalma, G. (2023). Benefits of Natural Antioxidants on Oral Health. Antioxidants, 12.","DOI":"10.3390\/antiox12061309"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Malcangi, G., Inchingolo, A.D., Trilli, I., Ferrante, L., Casamassima, L., Nardelli, P., Inchingolo, F., Palermo, A., Severino, M., and Inchingolo, A.M. (2025). Recent Use of Hyaluronic Acid in Dental Medicine. Materials, 18.","DOI":"10.3390\/ma18081863"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1590\/S1808-86942011000400011","article-title":"Peak Nasal Inspiratory Flow Evaluation as an Objective Method of Measuring Nasal Airflow","volume":"77","author":"Teixeira","year":"2011","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joms.2015.06.157","article-title":"Enlargement of the Pharynx Resulting from Surgically Assisted Rapid Maxillary Expansion","volume":"74","author":"Vinha","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0889-5406(87)90467-7","article-title":"The Nasal Airway Following Maxillary Expansion","volume":"91","author":"Warren","year":"1987","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/PL00001921","article-title":"Surgically Assisted Rapid Palatal Expansion. An Acoustic Rhinometric, Morphometric and Sonographic Investigation","volume":"62","author":"Wriedt","year":"2001","journal-title":"J. Orofac. Orthop."},{"key":"ref_121","first-page":"868","article-title":"Skeletal, Soft Tissue, and Airway Changes Following the Alternate Maxillary Expansions and Constrictions Protocol","volume":"84","author":"Yilmaz","year":"2014","journal-title":"Angle Orthod."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.12998\/wjcc.v8.i21.5371","article-title":"Seven-Year Follow-up of the Nonsurgical Expansion of Maxillary and Mandibular Arches in a Young Adult: A Case Report","volume":"8","author":"Yu","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.ijom.2011.12.037","article-title":"Orthodontic Measurements and Nasal Respiratory Function after Surgically Assisted Rapid Maxillary Expansion: An Acoustic Rhinometry and Rhinomanometry Study","volume":"41","author":"Zambon","year":"2012","journal-title":"Int. J. Oral. Maxillofac. Surg."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Laforgia, A., Inchingolo, A.M., Inchingolo, F., Sardano, R., Trilli, I., Di Noia, A., Ferrante, L., Palermo, A., Inchingolo, A.D., and Dipalma, G. (2025). Paediatric Dental Trauma: Insights from Epidemiological Studies and Management Recommendations. BMC Oral Health, 25.","DOI":"10.1186\/s12903-024-05222-5"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1746-160X-8-33","article-title":"Use of Dermal-Fat Grafts in the Post-Oncological Reconstructive Surgery of Atrophies in the Zygomatic Region: Clinical Evaluations in the Patients Undergone to Previous Radiation Therapy","volume":"8","author":"Inchingolo","year":"2012","journal-title":"Head Face Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1746-160X-6-28","article-title":"Fish-Hook Injuries: A Risk for Fishermen","volume":"6","author":"Inchingolo","year":"2010","journal-title":"Head Face Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.2041-1626.2010.00020.x","article-title":"Comparison between Traditional Surgery, CO2 and Nd:Yag Laser Treatment for Generalized Gingival Hyperplasia in Sturge-Weber Syndrome: A Retrospective Study","volume":"1","author":"Inchingolo","year":"2010","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Inchingolo, F., Inchingolo, A.M., Latini, G., Palmieri, G., Di Pede, C., Trilli, I., Ferrante, L., Inchingolo, A.D., Palermo, A., and Lorusso, F. (2023). Application of Graphene Oxide in Oral Surgery: A Systematic Review. Materials, 16.","DOI":"10.3390\/ma16186293"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Inchingolo, F., Inchingolo, A.M., Avantario, P., Settanni, V., Fatone, M.C., Piras, F., Di Venere, D., Inchingolo, A.D., Palermo, A., and Dipalma, G. (2023). The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417228"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/SCS.0b013e31815ca1cd","article-title":"Sublingual Ranula: A Closer Look to Its Surgical Management","volume":"19","author":"Mortellaro","year":"2008","journal-title":"J. Craniofac. Surg."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00001665-200503000-00021","article-title":"Autogenous Calvarial Bone Graft Harvest: Intraoperational Complications","volume":"16","author":"Sammartino","year":"2005","journal-title":"J. Craniofac. Surg."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Gasparro, R., Qorri, E., Valletta, A., Masucci, M., Sammartino, P., Amato, A., and Marenzi, G. (2018). Non-Transfusional Hemocomponents: From Biology to the Clinic-A Literature Review. Bioengineering, 5.","DOI":"10.3390\/bioengineering5020027"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/1752-1947-8-398","article-title":"Multidisciplinary Approach to Fused Maxillary Central Incisors: A Case Report","volume":"8","author":"Sammartino","year":"2014","journal-title":"J. Med. Case Rep."},{"key":"ref_134","unstructured":"(2025, May 28). Comparison of Skeletal and Dental Changes Between 2-Point and 4-Point Rapid Palatal Expanders, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/12637904\/."},{"key":"ref_135","unstructured":"(2025, May 28). Diagnosis and Treatment of Transverse Maxillary Deficiency, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/9082002\/."},{"key":"ref_136","unstructured":"(2025, May 28). Differential Assessment of Skeletal, Alveolar, and Dental Components Induced by Microimplant-Supported Midfacial Skeletal Expander (MSE), Utilizing Novel Angular Measurements from the Fulcrum, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/32656601\/."},{"key":"ref_137","unstructured":"(2025, May 28). Does Rapid Maxillary Expansion Affect Nasopharyngeal Airway? A Prospective Cone Beam Computerised Tomography (CBCT) Based Study, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/26827275\/."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.sleep.2005.12.014","article-title":"Gender Differences on Polysomnographic Findings in Greek Subjects with Obstructive Sleep Apnea Syndrome","volume":"7","author":"Vagiakis","year":"2006","journal-title":"Sleep Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.sleep.2009.10.005","article-title":"Obstructive Sleep Apnea Syndrome in the Sao Paulo Epidemiologic Sleep Study","volume":"11","author":"Tufik","year":"2010","journal-title":"Sleep Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bjorl.2020.06.014","article-title":"Are Reduced Internal Nasal Dimensions a Risk Factor for Obstructive Sleep Apnea Syndrome?","volume":"88","author":"Trindade","year":"2022","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Caggiano, M., Gasparro, R., D\u2019Ambrosio, F., Pisano, M., Di Palo, M.P., and Contaldo, M. (2022). Smoking Cessation on Periodontal and Peri-Implant Health Status: A Systematic Review. Dent. J., 10.","DOI":"10.3390\/dj10090162"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Canfora, F., Calabria, E., Cuocolo, R., Ugga, L., Buono, G., Marenzi, G., Gasparro, R., Pecoraro, G., Aria, M., and D\u2019Aniello, L. (2021). Burning Fog: Cognitive Impairment in Burning Mouth Syndrome. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.727417"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/term.3032","article-title":"Platelet-Rich Plasma Counteracts Detrimental Effect of High-Glucose Concentrations on Mesenchymal Stem Cells from Bichat Fat Pad","volume":"14","author":"Lecce","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_144","first-page":"S112","article-title":"Effect of rapid maxillary expansion on nasomaxillary structure and sleep disordered breathing in children with obstructive sleep apnoea","volume":"69","author":"Pirelli","year":"2025","journal-title":"Aust. Dent. J."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Galeotti, A., Gatto, R., Caruso, S., Piga, S., Maldonato, W., Sitzia, E., Viarani, V., Bompiani, G., Aristei, F., and Marzo, G. (2023). Effects of Rapid Palatal Expansion on the Upper Airway Space in Children with Obstructive Sleep Apnea (OSA): A Case-Control Study. Children, 10.","DOI":"10.3390\/children10020244"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1590\/2176-9451.20.3.043-049.oar","article-title":"Immediate Impact of Rapid Maxillary Expansion on Upper Airway Dimensions and on the Quality of Life of Mouth Breathers","volume":"20","author":"Izuka","year":"2015","journal-title":"Dent. Press J. Orthod."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1590\/2177-6709.22.3.079-088.oar","article-title":"Impact of Rapid Maxillary Expansion on Nasomaxillary Complex Volume in Mouth-Breathers","volume":"22","author":"Cappellette","year":"2017","journal-title":"Dent. Press J. Orthod."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s11325-020-02140-y","article-title":"Impact of Rapid Palatal Expansion on the Internal Nasal Valve and Obstructive Nasal Symptoms in Children","volume":"25","author":"Yoon","year":"2021","journal-title":"Sleep Breath."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4041\/kjod23.090","article-title":"Long-Term Effects of Maxillary Skeletal Expander Treatment on Functional Breathing","volume":"54","author":"Combs","year":"2024","journal-title":"Korean J. Orthod."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4041\/kjod24.102","article-title":"Long-Term Structural and Functional Nasomaxillary Evolution of Children with Mouth-Breathing after Rapid Maxillary Expansion: An 8-Year Follow-up Study","volume":"55","author":"Satto","year":"2025","journal-title":"Korean J. Orthod."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijporl.2018.09.029","article-title":"Nasal Function before and after Rapid Maxillary Expansion in Children: A Randomized, Prospective, Controlled Study","volume":"115","author":"Ottaviano","year":"2018","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/ejo\/cjab001","article-title":"Nasal Ventilation and Rapid Maxillary Expansion (RME): A Randomized Trial","volume":"43","author":"Iwasaki","year":"2021","journal-title":"Eur. J. Orthod."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijporl.2013.10.011","article-title":"Rapid Maxillary Expansion in Growing Patients: Correspondence between 3-Dimensional Airway Changes and Polysomnography","volume":"78","author":"Caprioglio","year":"2014","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Nota, A., Caruso, S., Caruso, S., Sciarra, F.M., Marino, A., Daher, S., Pittari, L., Gatto, R., and Tecco, S. (2022). Rapid Maxillary Expansion in Pediatric Patients with Sleep-Disordered Breathing: Cephalometric Variations in Upper Airway\u2019s Dimension. Appl. Sci., 12.","DOI":"10.3390\/app12052469"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1590\/2177-6709.22.4.061-069.oar","article-title":"Skeletal Effects of RME in the Transverse and Vertical Dimensions of the Nasal Cavity in Mouth-Breathing Growing Children","volume":"22","author":"Cappellette","year":"2017","journal-title":"Dent. Press J. Orthod."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/18\/6565\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:48:08Z","timestamp":1760035688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/18\/6565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":155,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcm14186565"],"URL":"https:\/\/doi.org\/10.3390\/jcm14186565","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,18]]}}}