{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:46:22Z","timestamp":1760060782191,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"NIA, National Institute on Aging","doi-asserted-by":"publisher","award":["NO1-AG-1\u20132109"],"award-info":[{"award-number":["NO1-AG-1\u20132109"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Blood pressure is associated with overt thyroid disorders, but the role of subclinical diseases is not clear, particularly when blood pressure is assessed at the clinical office. Ambulatory blood pressure monitoring over 24 h provides additional clinical information, which correlates with many cardiovascular endpoints. The aim of our work is to examine whether thyroid function is related to systolic and diastolic blood pressure assessed by ambulatory blood pressure monitoring. Methods: We enrolled 3277 subjects from the SardiNIA project. Thyroid function and ambulatory blood pressure monitoring were assessed in all the participants. Results: TSH was associated with average 24 h and daytime DBP in males but not in females, after adjusting for confounders (respectively, Coef \u22120.192 p = 0.025, and Coef. \u22120.021, p = 0.018). We found no association between TSH and DBP or SBP during nighttime. Conclusions: Low TSH in males is positively associated with high DBP. Further studies of underlying mechanisms will need to explore our findings.<\/jats:p>","DOI":"10.3390\/jcm14186580","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:24:25Z","timestamp":1758198265000},"page":"6580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Thyroid Function and Ambulatory Blood Pressure Monitoring"],"prefix":"10.3390","volume":"14","author":[{"given":"Nicia I.","family":"Profili","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Institute for Genetic and Biomedical Research, National Research Council, 08045 Lanusei, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-9815","authenticated-orcid":false,"given":"Michele","family":"Marongiu","sequence":"additional","affiliation":[{"name":"Institute for Genetic and Biomedical Research, National Research Council, 08045 Lanusei, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cucca","sequence":"additional","affiliation":[{"name":"Institute for Genetic and Biomedical Research, National Research Council, 08045 Lanusei, Italy"},{"name":"Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro P.","family":"Delitala","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy"},{"name":"Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1210\/jc.2003-030398","article-title":"Hypothyroidism and atherosclerosis","volume":"88","author":"Cappola","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1530\/EJE-12-0627","article-title":"Mechanisms in endocrinology: Heart failure and thyroid dysfunction","volume":"167","author":"Biondi","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0140-6736(01)06067-6","article-title":"Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: A 10-year cohort study","volume":"358","author":"Parle","year":"2001","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1056\/NEJM199411103311901","article-title":"Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons","volume":"331","author":"Sawin","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1530\/EJE-14-0182","article-title":"Prevalence of unknown thyroid disorders in a Sardinian cohort","volume":"171","author":"Delitala","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1089\/thy.2014.0028","article-title":"Guidelines for the treatment of hypothyroidism: Prepared by the american thyroid association task force on thyroid hormone replacement","volume":"24","author":"Jonklaas","year":"2014","journal-title":"Thyroid"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kim, J., Prasitlumkum, N., Randhawa, S., and Banerjee, D. (2021). Association between Subclinical Hypothyroidism and Incident Hypertension in Women: A Systematic Review and Meta-Analysis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10153318"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Delitala, A.P., Scuteri, A., Fiorillo, E., Lakatta, E.G., Schlessinger, D., and Cucca, F. (2019). Role of Adipokines in the Association between Thyroid Hormone and Components of the Metabolic Syndrome. J. Clin. Med., 8.","DOI":"10.3390\/jcm8060764"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.maturitas.2016.07.003","article-title":"Menopause modulates the association between thyrotropin levels and lipid parameters: The SardiNIA study","volume":"92","author":"Delitala","year":"2016","journal-title":"Maturitas"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1530\/EJE-09-0376","article-title":"Subclinical hyperthyroidism and blood pressure in a population-based prospective cohort study","volume":"161","author":"Volzke","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1210\/jc.2011-2768","article-title":"Serum thyroid-stimulating hormone levels are associated with blood pressure in children and adolescents","volume":"97","author":"Ittermann","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6053068","DOI":"10.1155\/2019\/6053068","article-title":"Gender-Specific Differences on the Association of Hypertension with Subclinical Thyroid Dysfunction","volume":"2019","author":"Zhang","year":"2019","journal-title":"Int. J. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"bvae088","DOI":"10.1210\/jendso\/bvae088","article-title":"Thyroid-related Hormones and Hypertension Incidence in Middle-Aged and Older Hispanic\/Latino Adults: The HCHS\/SOL Study","volume":"8","author":"Abasilim","year":"2024","journal-title":"J. Endocr. Soc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e230301","DOI":"10.20945\/2359-4292-2023-0301","article-title":"Associations of TSH, free T3, free T4, and conversion ratio with incident hypertension: Results from the prospective Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)","volume":"68","author":"Birck","year":"2024","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/HJH.0000000000002655","article-title":"Blood pressure characteristics of subclinical hypothyroidism: An observation study combined with office blood pressure and 24-h ambulatory blood pressure","volume":"39","author":"Cai","year":"2021","journal-title":"J. Hypertens."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ijcard.2014.09.200","article-title":"A high normal thyroid-stimulating hormone is associated with arterial stiffness, central systolic blood pressure, and 24-hour systolic blood pressure in males with treatment-naive hypertension and euthyroid","volume":"177","author":"Kwon","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/07420529808998694","article-title":"Circadian blood pressure and heart rate profiles in normotensive patients with mild hyperthyroidism","volume":"15","author":"Kohno","year":"1998","journal-title":"Chronobiol. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2265.2005.02301.x","article-title":"Ambulatory blood pressure monitoring in patients with hyperthyroidism before and after control of thyroid function","volume":"63","author":"Iglesias","year":"2005","journal-title":"Clin. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1365-2265.2008.03509.x","article-title":"Effects of 18 months of L-T4 replacement in women with subclinical hypothyroidism","volume":"71","author":"Adrees","year":"2009","journal-title":"Clin. Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e19343","DOI":"10.7717\/peerj.19343","article-title":"Subclinical hypothyroidism during pregnancy and the impact of levothyroxine therapy on pregnancy outcomes in women","volume":"13","author":"Zhou","year":"2025","journal-title":"PeerJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/011871529X324722250207072454","article-title":"Effect of Levothyroxine Therapy on Gestational Hypertension and Pre-Eclampsia in Pregnant Women with Subclinical Hypothyroidism, Hypothyroidism, and Thyroid Autoimmunity: A Systematic Review and Meta-analysis","volume":"25","author":"Aminorroaya","year":"2025","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1055\/s-0044-101756","article-title":"Associations Between Thyroid and Blood Pressure in Euthyroid Adults: A 9-Year Longitudinal Study","volume":"50","author":"Abdi","year":"2018","journal-title":"Horm. Metab. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/jch.13536","article-title":"Association of thyroid function with white coat hypertension and sustained hypertension","volume":"21","author":"Cai","year":"2019","journal-title":"J. Clin. Hypertens."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1210\/jc.2007-2674","article-title":"Free triiodothyronine has a distinct circadian rhythm that is delayed but parallels thyrotropin levels","volume":"93","author":"Russell","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2003.10.033","article-title":"Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions","volume":"213","author":"Bassett","year":"2003","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e21190","DOI":"10.1097\/MD.0000000000021190","article-title":"Effect of thyrotropin suppressive therapy on heart rate variability and QT dispersion in patients with differentiated thyroid cancer","volume":"99","author":"Liu","year":"2020","journal-title":"Medicine"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/18\/6580\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:48:03Z","timestamp":1760035683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/18\/6580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":27,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcm14186580"],"URL":"https:\/\/doi.org\/10.3390\/jcm14186580","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,9,18]]}}}