{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:49Z","timestamp":1760060749296,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish Orphan Biovitrum (SOBI)","award":["Hae-Ita-2019-243-Bor","PFIZER WP26453779\/EF03104"],"award-info":[{"award-number":["Hae-Ita-2019-243-Bor","PFIZER WP26453779\/EF03104"]}]},{"name":"Pfizer","award":["Hae-Ita-2019-243-Bor","PFIZER WP26453779\/EF03104"],"award-info":[{"award-number":["Hae-Ita-2019-243-Bor","PFIZER WP26453779\/EF03104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: The approach to physical activity in people with hemophilia (PwH) is still conditioned by many difficulties. Thus, a prospective observational pilot study has been carried out aiming to evaluate how an adequate and controlled training program can slow down the onset or evolution of arthropathy and improve musculoskeletal health and quality of life. Methods: Performed from April 2022 to April 2023, this study involved nine severe hemophilic A and B patients, aged &gt; 18 years old, on regular prophylaxis with replacement products. Participants, without changing the usual prophylaxis schedule and maintaining a trough level of at least 20% FVIII\/FIX before training, were involved in physical activity twice a week. Results: After 12 months, no increase in annual bleeding ratio (ABR) was observed, and baseline joint status (as assessable by HEAD US score, HJHS, and NRS) was maintained. Even if not statistically significant, a trend toward improvement in mean HEAD US score (15.55 vs. 13.11) and HJHS (14.4 vs. 11) from baseline was observed. Some of the physical tests performed showed a significant improvement at 6 months and 12 months from baseline (5 Rep Sit to Stand, Sit and Reach, and 6-minute Walking Test), meaning an improvement in leg strength, dorsal flexibility, and aerobic resistance. Conclusions: This is the first pilot study evaluating at 360 degrees the safety and impact of a controlled physical activity in PwH. No participant experienced bleedings or a worsening in joint status, but they experienced an improvement in articular functionality. Without changing the usual prophylaxis, scheduling training sessions according to individual pharmacokinetics turned out to be a safe and a cost-effective approach.<\/jats:p>","DOI":"10.3390\/jcm14186652","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:08:03Z","timestamp":1758542883000},"page":"6652","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The VincerEmo Pilot Study: Prospective Analysis of Controlled Physical Activity in People with severe Hemophilia"],"prefix":"10.3390","volume":"14","author":[{"given":"Federica","family":"Valeri","sequence":"first","affiliation":[{"name":"Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Citt\u00e0 della Salute e della Scienza, 10126 Turin, Italy"},{"name":"Division of Hematology, AOU Citt\u00e0 della Salute e della Scienza, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Dainese","sequence":"additional","affiliation":[{"name":"Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Citt\u00e0 della Salute e della Scienza, 10126 Turin, Italy"},{"name":"Division of Hematology, AOU Citt\u00e0 della Salute e della Scienza, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piera","family":"Merli","sequence":"additional","affiliation":[{"name":"Department of Orthopedy and Traumatology and Riabilitation, AOU Citt\u00e0 della Salute e della Scienza, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariella","family":"Galizia","sequence":"additional","affiliation":[{"name":"Sisport Spa SSD, 10151 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9049-9877","authenticated-orcid":false,"given":"Samuel","family":"Agostino","sequence":"additional","affiliation":[{"name":"Sisport Spa SSD, 10151 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Cunsolo","sequence":"additional","affiliation":[{"name":"Sisport Spa SSD, 10151 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola","family":"Sella","sequence":"additional","affiliation":[{"name":"Division of Hematology, AOU Citt\u00e0 della Salute e della Scienza, University of Turin, 10124 Turin, Italy"},{"name":"Department of Molecular Biotechnology and Health Sciences, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Valpreda","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Laboratory, AOU Citt\u00e0 della Salute e della Scienza, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagiulia","family":"Bailon","sequence":"additional","affiliation":[{"name":"Clinical Psychology Unit, Department of Neuroscience, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-5706","authenticated-orcid":false,"given":"Marco","family":"Miniotti","sequence":"additional","affiliation":[{"name":"Clinical Psychology Unit, Department of Neuroscience, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-1561","authenticated-orcid":false,"given":"Annamaria","family":"Porreca","sequence":"additional","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life, San Raffaele University, 00166 Rome, 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