{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:32:58Z","timestamp":1791401578295,"version":"4.3.3"},"reference-count":24,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yeungnam University Research Grant","award":["216A580036"],"award-info":[{"award-number":["216A580036"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Subchorionic placental cysts are rare, and their prevalence, etiology, and impact on pregnancy remain unclear. A 40-year-old woman presented at 283\/7 weeks of gestation with asymmetric fetal growth restriction. Ultrasonography at 353\/7 weeks of gestation revealed a newly detected cystic mass measuring 4 cm in diameter protruding from the fetal surface of the placenta. On pathological examination after delivery, multiple placental infarctions and multifocal perivillous fibrin deposits were diffusely observed throughout the placenta. Through a review of 16 cases of subchorionic placental cysts, including the present case, we found that the majority of cases exhibited abnormal placental pathology suggestive of hypoxia and were associated with unfavorable pregnancy outcomes, such as fetal growth restriction, preterm birth, and an increased risk of cesarean delivery. We suggest that they are associated with unfavorable pregnancy outcomes and may serve as a clinical marker of placental hypoxia.<\/jats:p>","DOI":"10.3390\/jcm14196698","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:27:53Z","timestamp":1758623273000},"page":"6698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Subchorionic Placental Cyst in a Woman with Fetal Growth Restriction: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"14","author":[{"given":"Hyo-Shin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yeungnam University Medical Center, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hye","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yeungnam University Medical Center, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jin","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yeungnam University Medical Center, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0219-0317","authenticated-orcid":false,"given":"Dae-Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yeungnam University Medical Center, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref_1","first-page":"458","article-title":"Massive Subchorionic Placental Cyst and Poor Fetal Growth: A Case Report","volume":"60","author":"Boulis","year":"2015","journal-title":"J. Reprod. Med."},{"key":"ref_2","first-page":"223","article-title":"Prenatal diagnosis of multiple large subchorionic placental cysts with intracystic hemorraghe","volume":"9","author":"Witters","year":"2018","journal-title":"Facts Views Vis. Obgyn."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tjog.2017.12.028","article-title":"A large subchorionic placental cyst with thalassemia minor without fetal growth restriction","volume":"57","author":"Lin","year":"2018","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"641","DOI":"10.7863\/jum.2002.21.6.641","article-title":"Placental surface cysts detected on sonography: Histologic and clinical correlation","volume":"21","author":"Brown","year":"2002","journal-title":"J. Ultrasound Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0002-9378(11)91716-5","article-title":"Maternal floor infarction: Relationship to X cells, major basic protein, and adverse perinatal outcome","volume":"167","author":"Vernof","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/1093526618821577","article-title":"Placental Chorionic Cyst Fluid Has Prothrombotic Properties and Differs from Amniotic Fluid","volume":"22","author":"Stolla","year":"2019","journal-title":"Pediatr. Dev. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"26s","DOI":"10.1097\/00006250-198603001-00008","article-title":"Intrauterine membranous cyst: A report of antenatal diagnosis and obstetric aspects in two cases","volume":"67","author":"Kirkinen","year":"1986","journal-title":"Obstet. Gynecol."},{"key":"ref_8","first-page":"285","article-title":"Subchorionic placental cyst: A cause of fetal growth retardation--ultrasound and color-flow Doppler diagnosis and follow-up","volume":"88","author":"Raga","year":"1996","journal-title":"J. Natl. Med. Assoc."},{"key":"ref_9","first-page":"439","article-title":"Subchorionic placental cyst: Histopathological and clinical aspects in two cases","volume":"88","author":"Ferrara","year":"1996","journal-title":"Pathologica"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1600-0412.1997.tb07999.x","article-title":"Intra-uterine growth retardation and transverse lie due to massive subchorionic thrombohematoma and overlying large subchorionic cyst","volume":"76","author":"Tam","year":"1997","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/uog.1057","article-title":"Placental surface cyst with contents less echogenic than amniotic fluid on a second-trimester ultrasonographic evaluation","volume":"23","author":"Oneson","year":"2004","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000100786","article-title":"Prenatal diagnosis of a large subchorionic placental cyst with intracystic hematomas: A case report","volume":"22","author":"Hong","year":"2007","journal-title":"Fetal Diagn. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10396-010-0276-5","article-title":"Placental multiple chorionic cysts in maternal scleroderma","volume":"37","author":"Shimada","year":"2010","journal-title":"J. Med. Ultrason."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1111\/jog.13365","article-title":"Multiple placental surface cysts with intracystic hemorrhaging: A case report and review of the literature","volume":"43","author":"Soyama","year":"2017","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"135.e1","DOI":"10.1016\/j.ajog.2025.04.070","article-title":"Prenatal diagnosis of subamniotic placental cysts","volume":"233","author":"Chansriniyom","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.placenta.2010.10.008","article-title":"Placenta weight percentile curves for singleton and twins deliveries","volume":"32","author":"Almog","year":"2011","journal-title":"Placenta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102458","DOI":"10.1016\/j.jogc.2024.102458","article-title":"Presence and Size of Placental Lakes on 20-Week Fetal Anatomy Ultrasound and Obstetrical Outcomes","volume":"46","author":"Keller","year":"2024","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_18","first-page":"459","article-title":"Placental mesenchymal dysplasia associated with severe preeclampsia: A case report Korean","volume":"54","author":"Na","year":"2011","journal-title":"J. Obstet. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Torres-Torres, J., Espino-y-Sosa, S., Martinez-Portilla, R., Borboa-Olivares, H., Estrada-Gutierrez, G., Acevedo-Gallegos, S., Ruiz-Ramirez, E., Velasco-Espin, M., Cerda-Flores, P., and Ramirez-Gonzalez, A. (2024). A Narrative Review on the Pathophysiology of Preeclampsia. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147569"},{"key":"ref_20","unstructured":"Cunningham, F.G., Bloom, S.L., Dashe, J.S., Spong, C.Y., Hoffman, B.L., and Casey, B.M. (2018). Williams Obstetrics, McGraw Hill. [25th ed.]."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.placenta.2019.07.006","article-title":"Clinicopathological characteristics of miscarriages featuring placental massive perivillous fibrin deposition","volume":"86","author":"Kim","year":"2019","journal-title":"Placenta"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1053\/j.semperi.2014.10.003","article-title":"Placental hypoxia: The lesions of maternal malperfusion","volume":"39","author":"Parks","year":"2015","journal-title":"Semin. Perinatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"316.e1","DOI":"10.1016\/j.ajog.2012.06.030","article-title":"Single-nucleotide polymorphisms in genes involved in placental function and unexplained stillbirth","volume":"207","author":"Ferrari","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2019.04.049","article-title":"Novel association of SNP rs479200 in EGLN1 gene with predisposition to preeclampsia","volume":"705","author":"Kumar","year":"2019","journal-title":"Gene"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/6698\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:47:35Z","timestamp":1760035655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/6698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":24,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["jcm14196698"],"URL":"https:\/\/doi.org\/10.3390\/jcm14196698","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]}}}