{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:25:47Z","timestamp":1781731547392,"version":"3.54.5"},"reference-count":21,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Scar management remains a significant challenge in plastic and reconstructive surgery, particularly when addressing atrophic, retractile, or fibrotic scars. Autologous fat grafting and hybrid fractional laser therapy have independently shown efficacy in improving scar quality. This study aims to evaluate the synergistic effect of their combination on clinical and functional scar outcomes. Methods: A prospective, comparative study was conducted on patients with cutaneous scars of various etiologies. Participants were treated with either hybrid fractional laser therapy alone (CO2 and 1570 nm Erbium-glass wavelengths) or a combined protocol of laser plus autologous lipofilling. Clinical outcomes were assessed at baseline and at 30, 60, and 90 days post-treatment using the Vancouver Scar Scale (VSS), patient satisfaction scores, and Visual Analog Scale (VAS) for pain and discomfort. Results: Patients receiving the combined treatment demonstrated significantly greater improvement in scar pigmentation, elasticity, pliability, and thickness compared to those treated with laser alone. Subjective symptoms, including pain and itching, were also more effectively alleviated. The volumetric and regenerative properties of adipose tissue, particularly its content of adipose-derived stem cells (ADSCs) and stromal vascular fraction (SVF), likely contributed to the enhanced outcomes observed. Conclusions: The combination of hybrid fractional laser therapy and autologous lipofilling offers a superior therapeutic strategy for scar remodeling compared to laser monotherapy. This integrated regenerative approach addresses both structural and biological aspects of scar tissue, making it a valuable protocol for personalized and effective scar management. Further randomized trials with larger sample sizes and histological validation are warranted to confirm these preliminary findings and refine therapeutic protocols.<\/jats:p>","DOI":"10.3390\/jcm14196708","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:48:37Z","timestamp":1758635317000},"page":"6708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hybrid Fractional Laser and Autologous Lipofilling: A Synergistic Strategy for Functional and Aesthetic Scar Remodeling"],"prefix":"10.3390","volume":"14","author":[{"given":"Gabriele","family":"Delia","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Hospital of Messina \u201cAOU Gaetano Martino\u201d, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Quattrocchi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Hospital of Messina \u201cAOU Gaetano Martino\u201d, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Micieli","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Hospital of Messina \u201cAOU Gaetano Martino\u201d, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Tambasco","sequence":"additional","affiliation":[{"name":"Plastic Surgery Unit, Ospedale San Carlo di Nancy, Via Aurelia 275, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Albanese","sequence":"additional","affiliation":[{"name":"Plastic Surgery Unit, Ospedale San Carlo di Nancy, Via Aurelia 275, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2281-2862","authenticated-orcid":false,"given":"Fabiana","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Hospital of Messina \u201cAOU Gaetano Martino\u201d, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cai, Y., Tian, J., Li, J., Liu, X., Li, F., Zhang, L., Xiao, S., Jia, C., and Deng, C. (2023). A novel combined technology for treating hypertrophic scars: Adipose tissue extract combined with fractional CO2 laser. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1284312"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2147\/CCID.S454514","article-title":"Tawfik Autologous Nanofat Injection Combined with Fractional CO2 Laser in the Treatment of Atrophic Acne Scars","volume":"17","author":"Rageh","year":"2024","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cps.2015.03.008","article-title":"Regenerative Approach to Scars, Ulcers and Related Problems with Fat Grafting","volume":"42","author":"Klinger","year":"2015","journal-title":"Clin. Plast. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2059513117728200","DOI":"10.1177\/2059513117728200","article-title":"Autologous fat grafting for scars, healing and pain: A review","volume":"3","author":"Riyat","year":"2017","journal-title":"Scars Burn. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-023-03480-8","article-title":"Efficacy of fractional CO2 laser in combination with stromal vascular fraction (SVF) compared with fractional CO2 laser alone in the treatment of burn scars: A randomized controlled clinical trial","volume":"14","author":"Roohaninasab","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5978\/islsm.14-RE-01","article-title":"The role of the CO2 laser and fractional CO2 laser in dermatology","volume":"23","author":"Omi","year":"2014","journal-title":"Laser Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/14764170510037752","article-title":"Utilizing fractional resurfacing in the treatment of therapy-resistant melasma","volume":"7","author":"Tannous","year":"2005","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/lsm.20048","article-title":"Fractional photothermolysis: A new concept for cutaneous remodeling using microscopic patterns of thermal injury","volume":"34","author":"Manstein","year":"2004","journal-title":"Lasers Surg. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/PRS.0000000000001590","article-title":"The Current state of fat grafting: A review of harvesting, processing, and injection techniques","volume":"136","author":"Strong","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/PRS.0b013e31821e70e7","article-title":"Autologous fat graft in postmastectomy pain syndrome","volume":"128","author":"Caviggioli","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2141.2005.05409.x","article-title":"Immunomodulatory effect of human adipose tissue-derived adult stem cells: Comparison with bone marrow mesenchymal stem cells","volume":"129","author":"Puissant","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/107632701300062859","article-title":"Multilineage cells from human adipose tissue: Implications for cell-based therapies","volume":"7","author":"Zuk","year":"2001","journal-title":"Tissue Eng."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/PRS.0b013e31829fe1b0","article-title":"Nanofat grafting: Basic research and clinical applications","volume":"132","author":"Tonnard","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/PRS.0000000000000504","article-title":"Adipose tissue-derived stromal cells inhibit TGF-\u03b21-induced differentiation of human dermal fibroblasts and keloid scar-derived fibroblasts in a paracrine fashion","volume":"134","author":"Spiekman","year":"2014","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jormas.2018.04.005","article-title":"Use of autologous fat graft and fractiononal CO2 laser to optimize the aesthetic and functional results in patients with severe burn outcomes of the face","volume":"119","author":"Hersant","year":"2018","journal-title":"J. Stomatol. Oral. Maxillofac. Surg."},{"key":"ref_16","first-page":"1","article-title":"Sculpting perfection: Advancements in hybrid laser therapy for scar management","volume":"40","author":"Battaglia","year":"2025","journal-title":"Lasers Med. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3109\/14764172.2013.854639","article-title":"Fractional CO2 lasers for the treatment of atrophic acne scars: A review of the literature","volume":"16","author":"Magnani","year":"2014","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/asj\/sjx183","article-title":"Nanofat Grafting for Scar Treatment and Skin Quality Improvement","volume":"38","author":"Uyulmaz","year":"2018","journal-title":"Aesthet. Surg. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2527349","DOI":"10.1155\/2016\/2527349","article-title":"Autologous fat grafting reduces pain in irradiated breast: A review of our experience","volume":"2016","author":"Caviggioli","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1097\/01.prs.0000256047.47909.71","article-title":"Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: A healing process mediated by adipose-derived adult stem cells","volume":"119","author":"Rigotti","year":"2007","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10103-024-04077-0","article-title":"Efficacy and safety of radiofrequency in the treatment of hidradenitis suppurativa: A systematic review","volume":"39","author":"Nilforoushzadeh","year":"2024","journal-title":"Lasers Med. Sci."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/6708\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:47:46Z","timestamp":1760035666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/6708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":21,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["jcm14196708"],"URL":"https:\/\/doi.org\/10.3390\/jcm14196708","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]}}}