{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:02Z","timestamp":1787028662788,"version":"build-2736575974"},"reference-count":85,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Peripheral neuropathy (PN) is a common complication of diabetes mellitus (DM) with prevalence estimates showing considerable variation across studies. This study aimed to assess the prevalence and risk factors of PN in adult Greek subjects with type 2 diabetes mellitus (T2DM). Methods: \u03a4he PRENEDIG (PREvalence of peripheral NEuropathy in type 2 DIabetes in Greece) study was a nationwide, cross-sectional multicenter study based on data collected from hospital-based diabetes clinics and primary care practices from January 2024 to June 2024 in Greece. Diabetic peripheral neuropathy (DPN) prevalence and severity were evaluated using the Neuropathy Symptom Score (NSS) and the Neuropathy Disability Score (NDS). Additional sensory assessment tools were considered to support clinical evaluation. Multivariate regression analysis examined the association between DPN and potential risk factors. Results: Among the study population (n = 1807), the overall DPN prevalence was 18.87% and increased with longer diabetes duration. DPN prevalence among participants with over 10 years of T2DM reached 26.49%. Logistic regression analysis identified several independent predictors of DPN including diabetes duration &gt; 10 years (p &lt; 0.001), arterial hypertension in participants with diabetes duration &lt; 10 years (OR = 2.69, CI: 1.68\u20134.30, p &lt; 0.001), HbA1c levels (OR = 1.20, CI: 1.10\u20131.31, p &lt; 0.001), and age (OR = 1.02, CI: 1.00\u20131.03, p = 0.024). An interaction-related association was observed, with arterial hypertension not increasing the risk of DPN any further in participants with disease duration &gt; 10 years (OR: 3.73 vs. 3.80 with or without arterial hypertension, respectively). Sensory assessment tools further validated DPN diagnosis. Conclusions: In Greece, DPN is a common complication, affecting nearly one in five T2DM patients. The results of the study reinforce the importance of routine screening, particularly among older patients and those with longer diabetes duration to facilitate early detection and timely management of DPN and its associated complications.<\/jats:p>","DOI":"10.3390\/jcm14196723","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T15:54:54Z","timestamp":1758642894000},"page":"6723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Nationwide Study on the Prevalence of Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus in Greece\u2014The PRENEDIG Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Ilias N.","family":"Migdalis","sequence":"first","affiliation":[{"name":"Diabetic Clinic, Lefkos Stavros Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos K.","family":"Tentolouris","sequence":"additional","affiliation":[{"name":"First Department of Propaedeutic Internal Medicine and Diabetes Centre, Medical School, National and Kapodistrian University of Athens, Laiko Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0236-8760","authenticated-orcid":false,"given":"Triantafyllos P.","family":"Didangelos","sequence":"additional","affiliation":[{"name":"First Department of Propaedeutic Internal Medicine and Diabetes Centre, Medical School, Aristotle University of Thessaloniki, Ahepa Hospital, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-785X","authenticated-orcid":false,"given":"Nikolaos","family":"Papanas","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine and Diabetes Centre, Medical School, Democritus University of Thrace, Alexandroupolis Hospital, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalini X.","family":"Bristianou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Diabetic Clinic, Lamia Hospital, 35100 Lamia, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia N.","family":"Mavrogiannaki","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine and Diabetes Centre, NIMTS Hospital, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the PRENEDIG Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108646","DOI":"10.1016\/j.diabres.2020.108646","article-title":"Prevalence of Diabetes and Pre-Diabetes in Greece. 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