{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:14:26Z","timestamp":1784294066217,"version":"3.55.0"},"reference-count":28,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Methionine (MET) positron emission tomography (PET) and cerebral blood volume (CBV) imaging provide complementary glioma assessment. This study compared MET and CBV across glioma subtypes defined by the 2021 World Health Organization Classification. Methods: This retrospective study enrolled 106 patients (mean age 41.9 \u00b1 12.4 years; 57 males) with MRI non-contrast-enhanced gliomas: 21 glioblastoma, isocitrate dehydrogenase (IDH)-wildtype (G); 50 astrocytoma, IDH-mutant (A); and 35 oligodendrogliomas, IDH-mutant, and 1p\/19q-codeleted (O). Relative CBVs (rCBVs) were measured in VOI-T2 and VOI-MET, and the MET tumor-to-normal (T\/N) ratio was calculated. Results: MET and rCBV were significantly correlated (r = 0.5, p &lt; 0.001); rCBV was higher in MET-positive tumors and predicted MET accumulation (area under the curve [AUC] = 0.72, cutoff = 2.99). In VOI-T2, rCBV and MET T\/N ratio were the highest in G and lowest in A (p &lt; 0.001). Receiver operating characteristic analyses showed no overall significant difference between MET and rCBV for differentiating G\/A\/O, but rCBV trended toward higher AUC values in key distinctions, such as G (0.736 vs. 0.612) or grade 4 (0.718 vs. 0.617). The increase in rCBV within the MET-positive region (VOI-MET\/VOI-T2 rCBV ratio) was significantly higher in A (119.8%, p = 0.002) than in the other groups (p = 0.01). Conclusions: rCBV differentiated glioma subtype with accuracy comparable to MET and could predict MET accumulation. However, its reliability for identifying MET-positive regions varied by subtype, being useful in A but limited in O. Recognizing these subtype-specific differences, rCBV can serve as a practical tool for evaluating non-contrast-enhanced gliomas.<\/jats:p>","DOI":"10.3390\/jcm14196777","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:05:13Z","timestamp":1758801913000},"page":"6777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of [11C]-Methionine Positron Emission Tomography and Cerebral Blood Volume Imaging in the Diagnosis of Non-Contrast-Enhanced Gliomas"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-0043","authenticated-orcid":false,"given":"Naoya","family":"Imai","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Chubu Neurorehabilitation Hospital, Minokamo 505-8503, Japan"},{"name":"Department of Neurosurgery, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4252-4780","authenticated-orcid":false,"given":"Hirohito","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Chubu Neurorehabilitation Hospital, Minokamo 505-8503, Japan"},{"name":"Department of Clinical Brain Sciences, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8932-9798","authenticated-orcid":false,"given":"Yuka","family":"Ikegame","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Chubu Neurorehabilitation Hospital, Minokamo 505-8503, Japan"},{"name":"Department of Clinical Brain Sciences, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7191-4841","authenticated-orcid":false,"given":"Shoji","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Morishima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Chubu Neurorehabilitation Hospital, Minokamo 505-8503, Japan"},{"name":"Department of Neurosurgery, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8951-7345","authenticated-orcid":false,"given":"Soko","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University, Tokyo 162-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University, Tokyo 162-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-3184","authenticated-orcid":false,"given":"Naoyuki","family":"Ohe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morio","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Chubu Neurorehabilitation Hospital, Minokamo 505-8503, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Muragaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University, Tokyo 162-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Chubu Neurorehabilitation Hospital, Minokamo 505-8503, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8778-2698","authenticated-orcid":false,"given":"Tsuyoshi","family":"Izumo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yasuda, S., Yano, H., Ikegame, Y., Ikuta, S., Maruyama, T., Kumagai, M., Muragaki, Y., Iwama, T., Shinoda, J., and Izumo, T. 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