{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:58:45Z","timestamp":1790625525517,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JCM"],"abstract":"<jats:p>Despite ongoing advancements in the field of heart failure, heart transplantation remains the definitive treatment for patients with advanced heart failure. Decades of research, surgical innovation, and progress in transplant immunology have enabled the overcoming of persistent challenges associated with this complex procedure. Since the initial preclinical experiments involving heart transplants in canines and primates, the process has been profoundly transformed through the development of the bioptome for endomyocardial biopsies and the introduction of immunosuppressive therapies. More recently, improvements in the preservation and transportation of donor hearts, as well as the utilization of cell-free DNA for evaluating graft rejection, are laying the groundwork for further advancements in non-invasive rejection diagnosis and the expansion of the donor pool.<\/jats:p>","DOI":"10.3390\/jcm14196805","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:31:28Z","timestamp":1758875488000},"page":"6805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heart Transplant: A Never-Ending Story"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-7424","authenticated-orcid":false,"given":"Daniele","family":"Masarone","sequence":"first","affiliation":[{"name":"Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Gravino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5669-574X","authenticated-orcid":false,"given":"Luigi","family":"Falco","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Catapano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7949-7771","authenticated-orcid":false,"given":"Cristiano","family":"Amarelli","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Transplant, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Caiazzo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Transplant, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Transplant, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-2691","authenticated-orcid":false,"given":"Michelle","family":"Kittleson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierino","family":"Di Silverio","sequence":"additional","affiliation":[{"name":"Campania Region Transplant Center, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.3390\/jcm12165217","article-title":"The ABC of Heart Transplantation-Part 1: Indication, Eligibility, Donor Selection, and Surgical Technique","volume":"12","author":"Masarone","year":"2023","journal-title":"J. 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