{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:47:26Z","timestamp":1784566046831,"version":"3.55.0"},"reference-count":65,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JCM"],"abstract":"<jats:p>Although most commonly diagnosed in the elderly population, aortic stenosis can affect younger patients, being the most frequent valvular disease requiring replacement interventions, either through surgical procedures (SAVR = surgical aortic valve replacement) or through transcatheter aortic valve implantation (TAVI). In young patients, aortic stenosis generally occurs due to congenital malformations, such as bicuspid aortic valves (BAVs), or to rheumatic valve disease, both of which present specific anatomical characteristics. There is an upward trend among young patients regarding TAVI, due to the possibility of avoiding the complications of open-heart surgery while offering a faster recovery, although it is important to note that complications, such as conduction disturbances, paravalvular leaks (PVL), or strokes, can arise. Because of the current lack of long-term data, the implications of these complications among young patients are not well established. Moreover, an important issue among young patients is the durability of the prosthesis, as patient survival is expected to exceed the device\u2019s lifespan. The purpose of this review is to assess the current data on the most common causes of aortic stenosis and outcomes of TAVI in young patients, focusing on subgroups of patients with bicuspid aortic stenosis or rheumatic aortic stenosis, while emphasizing the potential complications, the durability of the aortic prosthesis, and reintervention possibilities.<\/jats:p>","DOI":"10.3390\/jcm14196847","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:01:39Z","timestamp":1759154499000},"page":"6847","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcatheter Aortic Valve Implantation in Young Patients: Challenges and Perspectives\u2014A Narrative Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1276-8398","authenticated-orcid":false,"given":"Iulia D. D.","family":"Mo\u021b","sequence":"first","affiliation":[{"name":"4th Department of Internal Medicine, Department of Cardiology Rehabilitation, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela M.","family":"\u0218erban","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cNiculae St\u0103ncioiu\u201d Heart Institute, 400001 Cluj-Napoca, Romania"},{"name":"4th Department of Internal Medicine, Department of Cardiology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5540-3478","authenticated-orcid":false,"given":"Alexandru","family":"Achim","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cNiculae St\u0103ncioiu\u201d Heart Institute, 400001 Cluj-Napoca, Romania"},{"name":"4th Department of Internal Medicine, Department of Cardiology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0140-2194","authenticated-orcid":false,"given":"\u0218tefan D. C.","family":"Mo\u021b","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cNiculae St\u0103ncioiu\u201d Heart Institute, 400001 Cluj-Napoca, Romania"},{"name":"4th Department of Internal Medicine, Department of Cardiology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-7952","authenticated-orcid":false,"given":"Dana","family":"Pop","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, Department of Cardiology Rehabilitation, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"Department of Cardiology Rehabilitation, Clinical Rehabilitation Hospital, 400437 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"ref_1","first-page":"941","article-title":"Aortic valve disease in the older adult","volume":"13","author":"Bhatia","year":"2016","journal-title":"J. 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