{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:44:37Z","timestamp":1790113477054,"version":"4.0.1"},"reference-count":50,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JCM"],"abstract":"<jats:p>Glaucoma is a chronic, progressive optic neuropathy characterized by the degeneration of retinal ganglion cells. It is one of the leading causes of blindness worldwide, with elevated intraocular pressure (IOP) being the most significant modifiable risk factor. The objective of this paper is to assess the effectiveness of Direct Selective Laser Trabeculoplasty (DSLT) in the management of glaucoma and OHT based on analysis of available literature. Topical hypotensive medications are the preferred first-line therapy for both newly diagnosed open angle glaucoma (OAG) and ocular hypertension (OHT) over other treatment modalities for most patients. Medical glaucoma management, despite proven efficacy, is limited by issues of patient adherence, quality-of-life decrease, side effects, and ocular surface disease (OSD). Selective Laser Trabeculoplasty (SLT) has emerged as a safe, effective, and repeatable alternative to medical therapy for patients with open-angle glaucoma (OAG) and ocular hypertension (OHT). Direct Selective Laser Trabeculoplasty (DSLT) is a novel, non-contact laser treatment that delivers energy transsclerally to the trabecular meshwork (TM) without the use of a gonioscope. In recent studies, DSLT has demonstrated comparable efficacy to conventional SLT, including the multicenter randomized GLAUrious trial. It reduces IOP by 18\u201327%, often enabling reduction in or discontinuation of hypotensive topical medications. The non-contact, automated nature of DSLT simplifies the procedure, enhances patient comfort, and may expand access to laser therapy across diverse clinical settings. In conclusion, DSLT represents an innovative advancement in laser therapy for glaucoma, combining the clinical benefits of SLT with enhanced procedural efficiency and safety. Further long-term studies are needed to validate its durability, but existing evidence supports its use as a first-line or adjunctive treatment for OAG and OHT.<\/jats:p>","DOI":"10.3390\/jcm14196884","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T09:12:23Z","timestamp":1759223543000},"page":"6884","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-Contact Laser Therapy for Glaucoma: A Review of Direct Selective Laser Trabeculoplasty"],"prefix":"10.3390","volume":"14","author":[{"given":"Anna M.","family":"Koziorowska","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Centre of Postgraduate Medical Education, 01-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-4222","authenticated-orcid":false,"given":"Aleksandra","family":"Opala","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Centre of Postgraduate Medical Education, 01-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-4826","authenticated-orcid":false,"given":"Iwona","family":"Grabska-Liberek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Centre of Postgraduate Medical Education, 01-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in adults\u2014Screening, diagnosis, and management: A review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kemer, \u00d6.E., Mekala, P., Dave, B., and Kooner, K.S. (2024). Managing ocular surface disease in glaucoma treatment: A systematic review. Bioengineering, 11.","DOI":"10.3390\/bioengineering11101010"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/ceo.13989","article-title":"Medical therapy for glaucoma: A review","volume":"50","author":"Casson","year":"2022","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s40266-015-0282-9","article-title":"Pharmacotherapy and adherence issues in treating elderly patients with glaucoma","volume":"32","author":"Broadway","year":"2015","journal-title":"Drugs Aging"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ophtha.2019.10.022","article-title":"The association between medication adherence and visual field progression in the Collaborative Initial Glaucoma Treatment Study","volume":"127","author":"Niziol","year":"2020","journal-title":"Ophthalmology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/aos.16728","article-title":"Topical glaucoma medications\u2014Possible implications on the meibomian glands","volume":"102","author":"Fineide","year":"2024","journal-title":"Acta Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jtos.2023.05.012","article-title":"Impact of glaucoma medications on the ocular surface and how ocular surface disease can influence glaucoma treatment","volume":"29","author":"Kolko","year":"2023","journal-title":"Ocul. Surf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s40123-023-00831-9","article-title":"Challenging the \u201ctopical medications-first\u201d approach to glaucoma: A treatment paradigm in evolution","volume":"12","author":"Radcliffe","year":"2023","journal-title":"Ophthalmol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1136\/bjo.2010.188607","article-title":"Persistence of glaucoma medical therapy in the Glasgow Glaucoma Database","volume":"95","author":"Rahman","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Li, X., Balas, M., and Mathew, D.J. (2025). A review of ocular and systemic side effects in glaucoma pharmacotherapy. J. Clin. Transl. Ophthalmol., 3.","DOI":"10.3390\/jcto3010002"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/08164622.2021.1964331","article-title":"Systemic side effects of glaucoma medications","volume":"105","author":"Arbabi","year":"2022","journal-title":"Clin. Exp. Optom."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/aos.14926","article-title":"Comparative efficacy and safety of preserved versus preservative-free beta-blockers in patients with glaucoma or ocular hypertension: A systematic review","volume":"100","author":"Skov","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41073-019-0064-8","article-title":"SANRA\u2014A scale for the quality assessment of narrative review articles","volume":"4","author":"Baethge","year":"2019","journal-title":"Res. Integr. Peer Rev."},{"key":"ref_15","unstructured":"(2021). European Glaucoma Society Terminology and Guidelines for Glaucoma, 5th Edition. Br. J. Ophthalmol., 105, 1\u2013169."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e000611","DOI":"10.1136\/bmjophth-2020-000611","article-title":"Selective laser trabeculoplasty (SLT) performed by optometrists for patients with glaucoma and ocular hypertension: A scoping review","volume":"6","author":"Jones","year":"2021","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/ceo.12938","article-title":"Feasibility of laser trabeculoplasty in angle closure glaucoma: A review of favourable histopathological findings in narrow angles","volume":"45","author":"Matos","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1038\/s41433-018-0165-5","article-title":"Efficacy of selective laser trabeculoplasty in primary angle closure disease","volume":"32","author":"Raj","year":"2018","journal-title":"Eye"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/IIO.0000000000000483","article-title":"Selective laser trabeculoplasty","volume":"63","author":"Wu","year":"2023","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0014-4835(05)80093-4","article-title":"Selective targeting of trabecular meshwork cells: In vitro studies of pulsed and CW laser interactions","volume":"60","author":"Latina","year":"1995","journal-title":"Exp. Eye Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2147\/OPTH.S342787","article-title":"Morphologic and cellular changes induced by selective laser trabeculoplasty","volume":"16","author":"Gupta","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/ICU.0b013e328086aebf","article-title":"Mechanisms of action and efficacy of argon laser trabeculoplasty and selective laser trabeculoplasty","volume":"18","author":"Stein","year":"2007","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0161-6420(00)00660-6","article-title":"Comparison of the morphologic changes after selective laser trabeculoplasty and argon laser trabeculoplasty in human eye bank eyes","volume":"108","author":"Kramer","year":"2001","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/lsm.10203","article-title":"Acute ultrastructural changes of the trabecular meshwork after selective laser trabeculoplasty and low power argon laser trabeculoplasty","volume":"33","author":"Cvenkel","year":"2003","journal-title":"Lasers Surg. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/IJG.0b013e31825af0eb","article-title":"The effect of selective laser trabeculoplasty on aqueous humor dynamics in patients with ocular hypertension and primary open-angle glaucoma","volume":"22","author":"Alaghband","year":"2013","journal-title":"J. Glaucoma"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1167\/iovs.16-20710","article-title":"Mechanism of action of selective laser trabeculoplasty and predictors of response","volume":"58","author":"Gulati","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1001\/archopht.121.7.957","article-title":"Selective laser trabeculoplasty as primary treatment for open-angle glaucoma: A prospective, nonrandomized pilot study","volume":"121","author":"Melamed","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"ref_28","first-page":"743","article-title":"Long-term follow-up of selective laser trabeculoplasty in primary open-angle glaucoma","volume":"223","author":"Gracner","year":"2006","journal-title":"Klin. Monatsblatter Fur Augenheilkd."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1055\/s-2005-857955","article-title":"Long-term results after selective laser trabeculoplasty: A clinical study on 269 eyes","volume":"222","author":"Best","year":"2005","journal-title":"Klin. Monatsblatter Fur Augenheilkd."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/112067210601600116","article-title":"Long-term clinical results of selective laser trabeculoplasty in the treatment of primary open-angle glaucoma","volume":"16","author":"Weinand","year":"2006","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3928\/15428877-20070501-01","article-title":"Selective laser trabeculoplasty in phakic and pseudophakic eyes","volume":"38","author":"Werner","year":"2007","journal-title":"Ophthalmic Surg. Lasers Imaging"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00061198-200604000-00009","article-title":"Selective laser trabeculoplasty as initial and adjunctive treatment for open-angle glaucoma","volume":"15","author":"McIlraith","year":"2006","journal-title":"J. Glaucoma"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1055\/s-0043-102946","article-title":"Stellenwert der selektiven Lasertrabekuloplastik (SLT) [Status of Selective Laser Trabeculoplasty (SLT)]","volume":"234","author":"Schlote","year":"2017","journal-title":"Klin. Monatsblatter Fur Augenheilkd."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.survophthal.2014.06.006","article-title":"Systematic review and meta-analysis on the efficacy of selective laser trabeculoplasty in open-angle glaucoma","volume":"60","author":"Wong","year":"2015","journal-title":"Surv. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.ophtha.2019.11.017","article-title":"Real-world outcomes of selective laser trabeculoplasty in the United Kingdom","volume":"127","author":"Khawaja","year":"2020","journal-title":"Ophthalmology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.ophtha.2020.03.029","article-title":"Visual field outcomes from the multicenter, randomized controlled Laser in Glaucoma and Ocular Hypertension Trial (LiGHT)","volume":"127","author":"Wright","year":"2020","journal-title":"Ophthalmology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ophtha.2022.09.009","article-title":"Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial: Six-year results of primary selective laser trabeculoplasty versus eye drops for the treatment of glaucoma and ocular hypertension","volume":"130","author":"Gazzard","year":"2023","journal-title":"Ophthalmology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2415-15-1","article-title":"Efficacy of selective laser trabeculoplasty for normal tension glaucoma: 1-year results","volume":"15","author":"Lee","year":"2015","journal-title":"BMC Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e001563","DOI":"10.1136\/bmjophth-2023-001563","article-title":"Efficacy and safety of first-line or second-line selective laser trabeculoplasty for normal-tension glaucoma: A multicentre cohort study","volume":"9","author":"Nitta","year":"2024","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/tvst.10.3.5","article-title":"Automated direct selective laser trabeculoplasty: First prospective clinical trial","volume":"10","author":"Goldenfeld","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_41","unstructured":"(2025, July 29). Belkin Vision. Eagle Device User Guide. Rev. 7.2. Belkin Vision, 2024. Available online: https:\/\/www.myalcon.com\/international\/professional\/glaucoma\/."},{"key":"ref_42","first-page":"1918","article-title":"Translimbal direct selective laser trabeculoplasty (DSLT): Efficacy and safety results","volume":"65","author":"Belkin","year":"2024","journal-title":"Investig. Ophthalmol Vis Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1364\/BOE.390849","article-title":"Non-contact direct selective laser trabeculoplasty: Light propagation analysis","volume":"11","author":"Sacks","year":"2020","journal-title":"Biomed. Opt. Express"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1177\/11206721241301935","article-title":"Direct selective laser trabeculoplasty: A retrospective study","volume":"35","author":"Fossati","year":"2025","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e001922","DOI":"10.1136\/bmjophth-2024-001922","article-title":"First results of direct selective laser trabeculoplasty for the treatment of glaucoma","volume":"10","author":"Lanza","year":"2025","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/IJG.0000000000000464","article-title":"Transscleral selective laser trabeculoplasty without a gonioscopy lens","volume":"26","author":"Geffen","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_47","unstructured":"Gazzard, G., Congdon, N., Belkin, M., Azuara-Blanco, A., Blumenthal, E.Z., Gomelauri, K., Zaliniyan, M., Traverso, C.E., Bracha, Z., and Dvalishvili, A. (2025). Twelve-month outcomes from the GLAUrious trial of direct selective laser trabeculoplasty versus selective laser trabeculoplasty. Ophthalmology, in press."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/bjophthalmol-2021-319379","article-title":"Direct selective laser trabeculoplasty in open angle glaucoma study design: A multicentre, randomised, controlled, investigator-masked trial (GLAUrious)","volume":"107","author":"Congdon","year":"2023","journal-title":"Br. J. Ophthalmol."},{"key":"ref_49","unstructured":"Alcon (2025, July 29). Voyager DSLT System Data on File. Available online: https:\/\/www.myalcon.com\/professional\/glaucoma\/voyager-dslt\/."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11206721251339511","DOI":"10.1177\/11206721251339511","article-title":"Short-term results of direct laser trabeculoplasty (DSLT) in clinical practice","volume":"35","author":"Puerto","year":"2025","journal-title":"Eur. J. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/6884\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T09:46:22Z","timestamp":1759225582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/6884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,28]]},"references-count":50,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["jcm14196884"],"URL":"https:\/\/doi.org\/10.3390\/jcm14196884","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,28]]}}}