{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:46:46Z","timestamp":1759366006862,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Several prognostic factors, including the early recovery pattern of acute low back pain (ALBP), are related to the chronicity of LBP. However, the association between systemic symptoms and ALBP remains underexplored from a holistic perspective. Hence, this study aimed to investigate this relationship and identify novel clinical prognostic predictors for LBP. Methods: This retrospective cross-sectional study included patients with ALBP admitted to the Department of Korean Medicine Rehabilitation at the Dongguk University Bundang Hospital between 1 January 2021 and 30 April 2025. Data extracted from medical records included demographics, treatment-related information, pain characteristics, past medical history, and systemic symptoms. Statistical analyses included independent t-tests, Mann\u2013Whitney U tests, chi-squared tests, Fisher\u2019s exact tests, correlation analysis, and multiple linear regression models. Results: A total of 194 patients with ALBP were included in the analysis. Among systemic symptoms, dyspepsia was significantly associated with higher pain at discharge and smaller absolute and relative pain changes. Although sleep disturbance and constipation showed associations with higher pain at discharge in univariate analyses, these associations were not statistically significant in regression models. Beyond systemic symptoms, alcohol consumption was significantly associated with lower pain at discharge and greater relative pain change, while hospitalization and symptom duration exhibited non-linear relationships. These findings remained robust in sensitivity and subgroup analyses. Conclusions: Systemic symptoms, especially dyspepsia, may serve as prognostic factors impeding ALBP recovery, representing potential early markers for identifying patients at risk of chronicity. The findings highlight the prospect of multidimensional strategies in reducing pain and enhancing patients\u2019 quality of life in clinical practice.<\/jats:p>","DOI":"10.3390\/jcm14196969","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T12:22:03Z","timestamp":1759321323000},"page":"6969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Systemic Symptoms and Recovery in Acute Low Back Pain: A Retrospective Cross-Sectional Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6689-5408","authenticated-orcid":false,"given":"Ji-Ho","family":"Lee","sequence":"first","affiliation":[{"name":"College of Korean Medicine, Dongguk University Graduate School, Seoul 04620, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Hyun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine of Korean Medicine, Dongguk University Bundang Oriental Hospital, Seongnam-si 13601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine of Korean Medicine, Dongguk University Bundang Oriental Hospital, Seongnam-si 13601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Ho","family":"Keum","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine of Korean Medicine, Dongguk University Bundang Oriental Hospital, Seongnam-si 13601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo-Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Dongguk University Graduate School, Gyeongju 38066, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.1007\/s00586-006-1070-3","article-title":"Chapter 2 European guidelines for prevention in low back pain","volume":"15","author":"Burton","year":"2006","journal-title":"Eur. Spine J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s11916-008-0069-3","article-title":"What is mechanical back pain and how best to treat it?","volume":"12","author":"Chien","year":"2008","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_3","unstructured":"Bono, C.M., Schoenfeld, A.J., and Vaccaro, A.R. (2015). Treatment of acute lower back pain. Non-Operative Treatment of the Lumbar Spine, Springer."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pneurobio.2008.09.018","article-title":"Towards a theory of chronic pain","volume":"87","author":"Apkarian","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1533-2500.2008.00176.x","article-title":"Psychosocial differences between high-risk acute vs chronic low back pain patients","volume":"8","author":"Robert","year":"2008","journal-title":"Pain Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/01.phm.0000214259.06380.79","article-title":"Sleep disturbance in patients with chronic low back pain","volume":"85","author":"Marin","year":"2006","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2147\/NDT.S110162","article-title":"Association of depression with sleep quality might be greater than that of pain intensity among outpatients with chronic low back pain","volume":"12","author":"Wang","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2147\/CEOR.S134130","article-title":"The economic and humanistic costs of chronic lower back pain in Japan","volume":"9","author":"Montgomery","year":"2017","journal-title":"Clin. Outcomes Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/RHU.0b013e318247b96a","article-title":"Efficacy of multidisciplinary treatment for patients with chronic low back pain: A prospective clinical study in 395 patients","volume":"18","author":"Moradi","year":"2012","journal-title":"J. Clin. Rheumatol."},{"key":"ref_10","first-page":"189","article-title":"Low back pain: Risk factors for chronicity","volume":"64","author":"Valat","year":"1997","journal-title":"Rev. Rhum. Engl. Ed."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/00007632-198709000-00002","article-title":"1987 Volvo award in clinical sciences. A new clinical model for the treatment of low-back pain","volume":"12","author":"Waddell","year":"1987","journal-title":"Spine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e919","DOI":"10.1097\/PR9.0000000000000919","article-title":"Prognostic factors for pain chronicity in low back pain: A systematic review","volume":"6","author":"Nieminen","year":"2021","journal-title":"Pain Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/ejp.976","article-title":"Predicting recovery in patients with acute low back pain: A clinical prediction model","volume":"21","author":"Macaskill","year":"2017","journal-title":"Eur. J. Pain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.annemergmed.2011.09.012","article-title":"One-week and 3-month outcomes after an emergency department visit for undifferentiated musculoskeletal low back pain","volume":"59","author":"Friedman","year":"2012","journal-title":"Ann. Emerg. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/00325481.1982.11716098","article-title":"The review of systems: An important part of a comprehensive examination","volume":"71","author":"Schneiderman","year":"1982","journal-title":"Postgrad. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/AJP.0b013e31815d3601","article-title":"How common is back pain in women with gastrointestinal problems?","volume":"24","author":"Smith","year":"2008","journal-title":"Clin. J. Pain"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/AJP.0b013e31828b10fe","article-title":"The relationship between incontinence, breathing disorders, gastrointestinal symptoms, and back pain in women: A longitudinal cohort study","volume":"30","author":"Smith","year":"2014","journal-title":"Clin. J. Pain"},{"key":"ref_18","first-page":"43","article-title":"Influence of constipation in women in their twenties on low back pain","volume":"24","author":"Yu","year":"2018","journal-title":"J. Korean Orthop. Manip. Phys. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/AJP.0000000000000055","article-title":"The bidirectional relationship between pain intensity and sleep disturbance\/quality in patients with low back pain","volume":"30","author":"Alsaadi","year":"2014","journal-title":"Clin. J. Pain"},{"key":"ref_20","unstructured":"The Society of Korean Rehabilitation Medicine (2020). Korean Rehabilitation Medicine, Kunja Publisher. [5th ed.]."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Park, S.H., and Keum, D.H. (2024). Systemic symptoms as potential predictors of chronic neck pain on initial examination: Can systemic symptoms act as a predictor of neck pain?. J. Pers. Med., 14.","DOI":"10.3390\/jpm14070688"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.4103\/sja.SJA_543_18","article-title":"The STROBE guidelines","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi. J. Anaesth."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13013-017-0121-3","article-title":"Low back pain in older adults: Risk factors, management options and future directions","volume":"12","author":"Wong","year":"2017","journal-title":"Scoliosis Spinal Disord."},{"key":"ref_24","first-page":"1049","article-title":"Predictors of persistent disability and back pain in older adults with a new episode of care for back pain","volume":"18","author":"Rundell","year":"2017","journal-title":"Pain Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1007\/s00586-016-4684-0","article-title":"Red flags presented in current low back pain guidelines: A review","volume":"25","author":"Verhagen","year":"2016","journal-title":"Eur. Spine J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.amjmed.2021.07.021","article-title":"Evaluation and management of cauda equina syndrome","volume":"134","author":"Kuris","year":"2021","journal-title":"Am. J. Med."},{"key":"ref_27","unstructured":"Donnally, C.J., Margetis, K., and Varacallo, M.A. (2025). Vertebral Compression Fractures. StatPearls, StatPearls Publishing."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1007\/s00586-008-0753-3","article-title":"The course of the acute vertebral body fragility fracture: Its effect on pain, disability and quality of life during 12 months","volume":"17","author":"Suzuki","year":"2008","journal-title":"Eur. Spine J."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Sahbaie, P., Irvine, K.A., Liang, D.Y., Shi, X., and Clark, J.D. (2019). Mild traumatic brain injury causes nociceptive sensitization through spinal chemokine upregulation. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-55739-x"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Danielli, E., Simard, N., DeMatteo, C.A., Kumbhare, D., Ulmer, S., and Noseworthy, M.D. (2023). A review of brain regions and associated post-concussion symptoms. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1136367"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cgh.2008.03.021","article-title":"Risk factors for mortality in lower intestinal bleeding","volume":"6","author":"Strate","year":"2008","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_32","unstructured":"Center for Behavioral Health Statistics and Quality (2016). Additional Disorders for Consideration. Impact of the DSM-IV to DSM-5 Changes on the National Survey on Drug Use and Health, Substance Abuse and Mental Health Services Administration."},{"key":"ref_33","unstructured":"(2025, February 04). Rome Foundation, Rome IV Criteria. Available online: https:\/\/theromefoundation.org\/rome-iv\/rome-iv-criteria\/."},{"key":"ref_34","unstructured":"(2025, February 04). International Continence Society Committees, Nocturia\u2014Terminology Discussion. Available online: https:\/\/www.ics.org\/committees\/standardisation\/terminologydiscussions\/nocturia."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12955-019-1251-5","article-title":"The mediating role of sleep quality in the association between nocturia and health-related quality of life","volume":"17","author":"Choi","year":"2019","journal-title":"Health. Qual. Life Outcomes."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1080\/10790268.2010.11689700","article-title":"Comparing quantification of pain severity by verbal rating and numeric rating scales","volume":"33","author":"Dijkers","year":"2010","journal-title":"J. Spinal Cord Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/a-1304-3677","article-title":"Clinical relevance of changes in pain intensity in patients with specific back pain","volume":"160","author":"Haase","year":"2022","journal-title":"Z. Orthop. Unfall."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Gupta, A., Stead, T.S., and Ganti, L. (2024). Determining a meaningful R-squared value in clinical medicine. Acad. Med. Surg.","DOI":"10.62186\/001c.125154"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1097\/00007632-200112010-00009","article-title":"Spine loading characteristics of patients with low back pain compared with asymptomatic individuals","volume":"26","author":"Marras","year":"2001","journal-title":"Spine"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.jbiomech.2004.08.016","article-title":"Intra-abdominal pressure increases stiffness of the lumbar spine","volume":"38","author":"Hodges","year":"2005","journal-title":"J. Biomech."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.clinbiomech.2010.06.018","article-title":"Intra-abdominal pressure and abdominal wall muscular function: Spinal unloading mechanism","volume":"25","author":"Stokes","year":"2010","journal-title":"Clin. Biomech."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s004640090090","article-title":"Effects of prolonged increased intra-abdominal pressure on gastrointestinal blood flow in pigs","volume":"15","author":"Gudmundsson","year":"2001","journal-title":"Surg. Endosc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0079-6123(08)62764-8","article-title":"Visceral inputs to sensory pathways in the spinal cord","volume":"Volume 67","author":"Cervero","year":"1986","journal-title":"Progress in Brain Research"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/jom-1985-851214","article-title":"Viscerosomatic reflexes: A review","volume":"85","author":"Beal","year":"1985","journal-title":"J. Am. Osteopath. Assoc."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Brandl, A., Egner, C., Reer, R., Schmidt, T., and Schleip, R. (2022). Associations between deformation of the thoracolumbar fascia and activation of the erector spinae and multifidus muscle in patients with acute low back pain and healthy controls: A matched pair case-control study. Life, 12.","DOI":"10.20944\/preprints202209.0173.v1"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11682-017-9705-z","article-title":"Abnormal brain structure implicated in patients with functional dyspepsia","volume":"12","author":"Liu","year":"2018","journal-title":"Brain Imaging Behav."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.nlm.2011.11.003","article-title":"Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats","volume":"97","author":"Yan","year":"2012","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-540-79090-7_2","article-title":"Visceral pain: The neurophysiological mechanism","volume":"194","author":"Sengupta","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e69275","DOI":"10.5812\/aapm.69275","article-title":"The association between constipation or stool consistency and pain severity in patients with chronic pain","volume":"8","author":"Arai","year":"2018","journal-title":"Anesth. Pain Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bja.2022.03.010","article-title":"Association between alcohol consumption and chronic pain: A systematic review and meta-analysis","volume":"129","author":"Karimi","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1093\/pm\/pny032","article-title":"Moderate alcohol consumption is associated with reduced pain and fibromyalgia symptoms in chronic pain patients","volume":"19","author":"Scott","year":"2018","journal-title":"Pain Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"755","DOI":"10.15288\/jsad.24-00144","article-title":"Too insensitive to care: Alcohol increases human aggression by increasing pain threshold","volume":"86","author":"DeWall","year":"2024","journal-title":"J. Stud. Alcohol. Drugs."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"a171","DOI":"10.1136\/bmj.a171","article-title":"Prognosis in patients with recent onset low back pain in Australian primary care: Inception cohort study","volume":"337","author":"Henschke","year":"2008","journal-title":"BMJ"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/papr.12704","article-title":"Clinical manifestation of acute, subacute, and chronic low back pain in different age groups: Low back pain in 35,446 patients","volume":"18","author":"Keller","year":"2018","journal-title":"Pain Pract."},{"key":"ref_55","unstructured":"GBD 2021 Low Back Pain Collaborators (2023). Global, regional, and national burden of low back pain, 1990\u20132020, its attributable risk factors, and projections to 2050: A systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol., 22, 316\u2013329."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e002426","DOI":"10.1136\/bmjdrc-2021-002426","article-title":"Association between type 2 diabetes and chronic low back pain in general practices in Germany","volume":"9","author":"Jacob","year":"2021","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Zhou, W.B.S., Meng, J., and Zhang, J. (2021). Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?. Front. Mol. Neurosci., 14.","DOI":"10.3389\/fnmol.2021.785214"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"9065325","DOI":"10.1155\/2024\/9065325","article-title":"Influence of Depression on Pain and Disability in Patients with Chronic Low Back Pain after Physical Therapy: A Secondary Analysis of a Randomized Controlled Trial","volume":"2024","author":"Wang","year":"2024","journal-title":"Depress. Anxiety"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(02)00009-6","article-title":"Descending control of pain","volume":"66","author":"Millan","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00302139","article-title":"How many days of bed rest for acute low back pain? Objective assessment of trunk function","volume":"1","author":"Szpalski","year":"1992","journal-title":"Eur. Spine J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/6969\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T12:28:25Z","timestamp":1759321705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/6969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":60,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["jcm14196969"],"URL":"https:\/\/doi.org\/10.3390\/jcm14196969","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}