{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:22:57Z","timestamp":1788387777320,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HANDOK Inc.","award":["HD-CR"],"award-info":[{"award-number":["HD-CR"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Excessive alcohol consumption leads to hangovers, which cause discomfort and reduce work efficiency, resulting in socioeconomic losses. Theracurmin, known for its antioxidant and hepatoprotective properties, may help mitigate these effects. We evaluated the efficacy and safety of two Theracurmin-based products in alleviating hangover symptoms in humans. Methods: A randomized, double-blind, placebo-controlled, crossover trial was conducted in 27 healthy adults, with a balanced distribution of men and women. Two formulations were tested: Ready Q, containing Theracurmin, Hovenia dulcis Thunb. extract powder, and L-glutathione yeast extract; and Theracurmin, containing only Theracurmin. The products were administered on designated visit days, followed by an alcohol challenge 30 min after administration. Blood and breath alcohol profiles were assessed 15 h post-consumption, and participants completed a hangover symptom questionnaire. Results: Compared to placebo, Ready Q resulted in a significantly lower area under the curve (AUC) for serum alcohol concentration (\u221294.92 mg\u00b7h\/dL [\u2212170.91, \u221218.93]), as well as lower AUC (\u22128.441 mg\u00b7h\/dL [\u221211.713, \u22125.169]) for serum acetaldehyde. Theracurmin showed similar effects, with reduced AUC (\u2212117.21 mg\u00b7h\/dL [\u2212194.20, \u221240.22]) for serum alcohol concentration, and lower AUC (\u22128.161 mg\u00b7h\/dL [\u221212.597, \u22123.725]) for corrected serum acetaldehyde levels. Conclusions: These findings suggest that both products effectively enhance alcohol metabolism in healthy adults, underscoring their potential as interventions for alleviating alcohol hangovers.<\/jats:p>","DOI":"10.3390\/jcm14196996","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:07:48Z","timestamp":1759417668000},"page":"6996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Theracurmin Products for Alleviating Alcohol Hangovers in Healthy Adults"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5389-8339","authenticated-orcid":false,"given":"Yeongtaek","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"},{"name":"Research Institute of Medical Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4624-7369","authenticated-orcid":false,"given":"Paul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"},{"name":"Research Institute of Medical Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3558-8516","authenticated-orcid":false,"given":"Minji","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-800X","authenticated-orcid":false,"given":"Sung-Vin","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-2918","authenticated-orcid":false,"given":"Bo-Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"},{"name":"East-West Medical Research Institute, Kyung Hee University, Seoul 02447, Republic of Korea"},{"name":"Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-7315","authenticated-orcid":false,"given":"Hyunjung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"},{"name":"Research Institute of Medical Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Singh, L., Joshi, T., Tewari, D., Echeverr\u00eda, J., Mocan, A., Sah, A.N., Parvanov, E., Tzvetkov, N.T., Ma, Z.F., and Lee, Y.Y. 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