{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T16:10:13Z","timestamp":1759767013414,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: This study aims to evaluate the effectiveness of a combined rehabilitative program integrating Graded Motor Imagery (GMI) and Occupational Therapy in improving upper limb function and autonomy in individuals with acquired brain injuries (ABIs), including stroke and traumatic brain injury. Methods: Twelve patients (mean age of 56.4 years) underwent a six-week intervention combining GMI and Occupational Therapy. Outcome measures included the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH), Jebsen Taylor Hand Function Test (JTHFT), Canadian Occupational Performance Measure (COPM), 12-Item Short Form Health Survey (SF-12), Numeric Rating Scale for pain (NRS), and Montreal Cognitive Assessment (MoCA). Assessments were conducted at baseline, post-treatment, and at 3- and 6-month follow-ups. Data were analyzed using the Wilcoxon signed-rank test. Results: Statistically significant improvements (p &lt; 0.05) were found in upper limb function (DASH), occupational performance and satisfaction (COPM), and physical health status (SF-12 physical component). Specific gains in hand function\u2014particularly in writing and eating\u2014were detected using the JTHFT. No significant changes were observed in pain perception or mental health outcomes. Conclusions: The integration of GMI with Occupational Therapy appears to be a promising and well-tolerated intervention for enhancing motor function and daily life participation in individuals with ABI. Although the small sample limits generalizability, these preliminary findings support further investigation through larger, controlled studies.<\/jats:p>","DOI":"10.3390\/jcm14197060","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:05:06Z","timestamp":1759763106000},"page":"7060","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Occupational Therapy Treatment Associated with Graded Motor Imagery (GMI) for the Recovery of Hand Function in Patients with Acquired Brain Injuries: Outcome Research"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0172-1427","authenticated-orcid":false,"given":"Francescaroberta","family":"Panuccio","sequence":"first","affiliation":[{"name":"Department of Human Neurosciences, Sapienza University of Rome, Viale dell\u2019Universit\u00e0, 30, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9043-5686","authenticated-orcid":false,"given":"Giovanni","family":"Galeoto","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences, Sapienza University of Rome, Viale dell\u2019Universit\u00e0, 30, 00185 Rome, Italy"},{"name":"IRCCS Neuromed, Via Atinense, 18, 86077 Pozzilli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Mastropierro","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences, Sapienza University of Rome, Viale dell\u2019Universit\u00e0, 30, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Marcellini","sequence":"additional","affiliation":[{"name":"Hospital San Giovanni Battista, 30, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5707-6861","authenticated-orcid":false,"given":"Andrea","family":"Marini Padovani","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences, Sapienza University of Rome, Viale dell\u2019Universit\u00e0, 30, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-5303","authenticated-orcid":false,"given":"Anna","family":"Berardi","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences, Sapienza University of Rome, Viale dell\u2019Universit\u00e0, 30, 00185 Rome, Italy"},{"name":"IRCCS Neuromed, Via Atinense, 18, 86077 Pozzilli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Goldman, L., Siddiqui, E.M., Khan, A., Jahan, S., Rehman, M.U., Mehan, S., Sharma, R., Budkin, S., Kumar, S.N., and Sahu, A. 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