{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:47:52Z","timestamp":1760143672646,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2014ricerca corrente"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: This study examined changes in psychological adjustment among patients with Anorexia Nervosa (AN) and Binge Eating Disorder (BED) following a 3-week inpatient multidisciplinary (disease-tailored) rehabilitation program. Methods: twenty consecutive Italian female adults with a diagnosis of AN (mean age \u00b1 SD: 25.9 \u00b1 9.4 years; mean Body Mass Index: BMI: kg\/m2: 15.8 \u00b1 1.61) and fifteen consecutive Italian female adults with diagnosis of BED (mean age \u00b1 SD: 43.5 \u00b1 15.3 years; mean Body Mass Index: BMI: kg\/m2: 41.1 \u00b1 7.82) were admitted to the study. Psychological functioning and well-being were assessed pre- and post-intervention using the Strengths and Difficulties Questionnaire and the Psychological General Well-Being Index. Results: Significant improvements in emotional symptoms [F(1, 31) = 21.1973, p &lt; 0.001, \u019e2p = 0.406] and overall psychological functioning [F(1, 31) = 10.0062, p = 0.373, \u019e2p = 0.026] were observed in both groups, with the most pronounced changes in internalizing symptoms, such as anxiety and depression. Changes in BMI were significantly associated with emotional symptoms, vitality [F(1, 31) = 4.89, p = 0.035, \u019e2p = 0.136], and total well-being scores [F(1, 31) = 6.341, p = 0.017, \u019e2p = 0.170]. By contrast, no significant changes were observed in domains such as behavioral problems, hyperactivity\/inattention, and peer relationships, probably indicating the need for more prolonged and targeted, domain-specific interventions. Conclusions: A 3-week inpatient multidisciplinary program was associated with improvements in internalizing symptoms and psychological well-being in women with AN and BED. Domains such as behavioral regulation and social functioning showed limited change, indicating the need for longer and targeted psychosocial components.<\/jats:p>","DOI":"10.3390\/jcm14197127","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:47:08Z","timestamp":1760104028000},"page":"7127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychological Adjustment in Patients with Anorexia Nervosa and Binge Eating Disorder Following a 3-Week Inpatient Multidisciplinary Rehabilitation Program"],"prefix":"10.3390","volume":"14","author":[{"given":"Anna","family":"Guerrini Usubini","sequence":"first","affiliation":[{"name":"Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 28824 Piancavallo-Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Ducale","sequence":"additional","affiliation":[{"name":"Psychology Research Laboratory, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 28824 Piancavallo-Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-5400","authenticated-orcid":false,"given":"Adele","family":"Bondesan","sequence":"additional","affiliation":[{"name":"Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 28824 Piancavallo-Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Caroli","sequence":"additional","affiliation":[{"name":"Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 28824 Piancavallo-Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1227-1747","authenticated-orcid":false,"given":"Francesca","family":"Frigerio","sequence":"additional","affiliation":[{"name":"Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 28824 Piancavallo-Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Savino","sequence":"additional","affiliation":[{"name":"Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 28824 Piancavallo-Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Abbruzzese","sequence":"additional","affiliation":[{"name":"Division of Auxology, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 28824 Piancavallo-Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2633-9822","authenticated-orcid":false,"given":"Gianluca","family":"Castelnuovo","sequence":"additional","affiliation":[{"name":"Psychology Research Laboratory, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 28824 Piancavallo-Verbania, Italy"},{"name":"Department of Psychology, Catholic University of Milan, 20123 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-4133","authenticated-orcid":false,"given":"Alessandro","family":"Sartorio","sequence":"additional","affiliation":[{"name":"Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 28824 Piancavallo-Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Publishing. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biopsych.2018.03.014","article-title":"Prevalence and correlates of DSM-5\u2013defined eating disorders in a nationally representative sample of US adults","volume":"84","author":"Udo","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.clinthera.2020.12.003","article-title":"A narrative review of sex differences in eating disorders: Is there a biological basis?","volume":"43","author":"Culbert","year":"2021","journal-title":"Clin. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Capuano, E.I., Ruocco, A., Scazzocchio, B., Zanchi, G., Lombardo, C., Silenzi, A., Ortona, E., and Var\u00ec, R. (2025). Gender differences in eating disorders. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1583672"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/10640266.2023.2196492","article-title":"Prevalence of non-suicidal self-injury, suicidal ideation, suicide attempts, suicide mortality in eating disorders: A systematic review and meta-analysis","volume":"31","author":"Amiri","year":"2023","journal-title":"Eat. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sander, J., Moessner, M., and Bauer, S. (2021). Depression, anxiety and eating disorder-related impairment: Moderators in female adolescents and young adults. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18052779"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s40337-022-00654-2","article-title":"Psychiatric and medical comorbidities of eating disorders: Findings from a rapid review of the literature","volume":"10","author":"Hambleton","year":"2022","journal-title":"J. Eat. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1017\/S1352465808004736","article-title":"Cognitive behavior therapy for eating disorders","volume":"36","author":"Cooper","year":"2008","journal-title":"Behav. Cogn. Psychother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"102354","DOI":"10.1016\/j.cpr.2023.102354","article-title":"A systematic review and meta-analysis of intensive treatment options for adults with eating disorders","volume":"106","author":"Johnson","year":"2023","journal-title":"Clin. Psychol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s40519-024-01665-5","article-title":"Inpatient treatments for adults with anorexia nervosa: A systematic review of literature","volume":"29","author":"Toppino","year":"2024","journal-title":"Eat. Weight Disord.-Stud. Anorex. Bulim. Obes."},{"key":"ref_11","unstructured":"National Institute for Health and Care Excellence (NICE) (2017). Eating Disorders: Recognition and Treatment, NICE."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.paid.2010.05.005","article-title":"The Strengths and Difficulties Questionnaire (SDQ). Early evidence of its reliability and validity in a community sample of Italian children","volume":"49","author":"Salcuni","year":"2010","journal-title":"Personal. Individ. Differ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1192\/bjp.177.6.534","article-title":"Using the Strengths and Difficulties Questionnaire (SDQ) to screen for child psychiatric disorders in a community sample","volume":"177","author":"Goodman","year":"2000","journal-title":"Br. J. Psychiatry"},{"key":"ref_14","unstructured":"Dupuy, H.J. (1984). The psychological general well-being (PGWB) index. Assessment of Quality of Life in Clinical Trials of Cardiovascular Therapies, Le Jacq Publishing."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1477-7525-4-88","article-title":"Development and validation of the short version of the Psychological General Well-Being Index (PGWB-S)","volume":"14","author":"Grossi","year":"2006","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/0004867414555814","article-title":"Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of eating disorders","volume":"48","author":"Hay","year":"2014","journal-title":"Aust. New Zealand J. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1176\/appi.ajp.23180001","article-title":"The American Psychiatric Association practice guideline for the treatment of patients with eating disorders","volume":"180","author":"Crone","year":"2023","journal-title":"Am. J. Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/01.psy.0000221254.77675.f5","article-title":"Psychiatric comorbidities of female inpatients with eating disorders","volume":"68","author":"Blinder","year":"2006","journal-title":"Psychosom. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.psychres.2015.09.008","article-title":"Psychiatric comorbidity in women and men with eating disorders results from a large clinical database","volume":"230","author":"Ulfvebrand","year":"2015","journal-title":"Psychiatry Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jad.2015.06.039","article-title":"Mood disorders in eating disorder patients: Prevalence and chronology of ONSET","volume":"185","author":"Godart","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/erv.2733","article-title":"A systematic review of outcomes following residential treatment for eating disorders","volume":"28","author":"Peckmezian","year":"2020","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Granero, R. (2022). Role of nutrition and diet on healthy mental state. Nutrients, 10.","DOI":"10.3390\/nu14040750"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1037\/ccp0000245","article-title":"The efficacy of cognitive-behavioral therapy for eating disorders: A systematic review and meta-analysis","volume":"85","author":"Linardon","year":"2017","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s40337-023-00906-9","article-title":"Short-term effects of a multidisciplinary inpatient intensive rehabilitation treatment on body image in anorexia nervosa","volume":"11","author":"Brusa","year":"2023","journal-title":"J. Eat. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/erv.2369","article-title":"Day hospital treatment for anorexia nervosa: A 12-month follow-up study","volume":"23","author":"Marzola","year":"2015","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-0031-1275669","article-title":"Effects of inpatient treatment on eating disorder symptoms, health-related quality of life and personal resources in anorexia and bulimia nervosa","volume":"61","author":"Tagay","year":"2011","journal-title":"Psychother. Psychosom. Med. Psychol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1080\/10640266.2012.715512","article-title":"Eating disorders in men: Underdiagnosed, undertreated, and misunderstood","volume":"20","author":"Strother","year":"2012","journal-title":"Eat. Disord."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/7127\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:03:08Z","timestamp":1760104988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/19\/7127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":27,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["jcm14197127"],"URL":"https:\/\/doi.org\/10.3390\/jcm14197127","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]}}}