{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:44:27Z","timestamp":1769571867457,"version":"3.49.0"},"reference-count":34,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: This article evaluates the reconstructive potential and functional outcomes, as well as the risks and potential perioperative complications of using free flaps in patients with advanced-stage malignant laryngeal neoplasms who require salvage surgery and reconstruction. Additionally, it assesses the effectiveness of various flap harvesting and in-setting techniques, including the performance of microvascular anastomoses. Materials and Methods: This retrospective study included 13 male patients (age range 47\u201376 years) diagnosed with laryngeal neoplasms, who were referred to the Department of Otolaryngology at the University of Verona between 2017 and 2022. All patients underwent salvage total laryngectomy followed by concurrent reconstructive surgery utilizing microvascular flaps. Recovery of function (phonation) and incidence of complications were evaluated in a follow-up of at least three years. Results: Only one patient experienced necrotic failure of the microvascular free flap, probably due to post-op complications. The patient required revision on the 10th day after surgery and was reconstructed using a pedicled pectoralis major muscle flap. Two patients developed a pharyngocutaneous fistula. Other three patients had pharyngoesophageal stenosis, two experienced recurrence, and one patient passed away due to septic shock. All patients achieved satisfactory functional outcomes regarding vocalization, while complete oral intake was restored in eight patients. Conclusions: Considering the limited sample size, the findings suggest that microvascular flaps represent a feasible option for reconstructing advanced laryngeal tumors, though complication rate may still be considerable. Tailoring reconstructive approaches to individual patients may enhance surgical outcomes.<\/jats:p>","DOI":"10.3390\/jcm14207155","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:50:16Z","timestamp":1760107816000},"page":"7155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microvascular Free Flap Reconstruction After Salvage Total Laryngectomy: Experience of the Verona University"],"prefix":"10.3390","volume":"14","author":[{"given":"Riccardo","family":"Nocini","sequence":"first","affiliation":[{"name":"Unit of Otorhinolaryngology, Head and Neck Department, Azienda Ospedaliera Universitaria Integrata, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Gobbo","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology, Head and Neck Department, Azienda Ospedaliera Universitaria Integrata, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Arietti","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology, Head and Neck Department, Azienda Ospedaliera Universitaria Integrata, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Molteni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy"},{"name":"Otolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero, Universitaria of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Sacchetto","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology, Head and Neck Department, Azienda Ospedaliera Universitaria Integrata, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-0500","authenticated-orcid":false,"given":"Giorgio","family":"Barbera","sequence":"additional","affiliation":[{"name":"Maxillo Facial Surgery Unit, Head and Neck Department, University of Verona, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Colapinto","sequence":"additional","affiliation":[{"name":"Maxillo Facial Surgery Unit, Head and Neck Department, University of Verona, 37134 Verona, Italy"},{"name":"Department of Biomedical, Surgical and Dental Sciences, Universit\u00e0 Degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-0984","authenticated-orcid":false,"given":"Massimo","family":"Del Fabbro","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, Universit\u00e0 Degli Studi di Milano, 20122 Milan, Italy"},{"name":"Unit of Maxillofacial Surgery and Dentistry, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2354-361X","authenticated-orcid":false,"given":"Funda","family":"Goker","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, Universit\u00e0 Degli Studi di Milano, 20122 Milan, Italy"},{"name":"Unit of Maxillofacial Surgery and Dentistry, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"},{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul Ayd\u0131n University, 34295 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"ref_1","first-page":"492","article-title":"Reconstruction for Salvage Laryngectomy with Limited Pharyngectomy","volume":"150","author":"Moreno","year":"2024","journal-title":"Arch. 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