{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:03:56Z","timestamp":1792242236412,"version":"4.4.0"},"reference-count":32,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: To evaluate whether incorporating both diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) in pituitary MRI examinations improves differential diagnosis by providing additional diagnostic value. Methods: A retrospective analysis was performed on 88 patients with histologically confirmed sellar or parasellar tumors who underwent 1.5T MRI with DWI and dynamic susceptibility contrast PWI (DSC-PWI) between October 2007 and April 2023. DWI parameters included minimum apparent diffusion coefficient (ADCmin) and relative ADCmin (rADCmin). PWI parameters included mean and maximum relative cerebral blood volume (rCBV, rCBVmax) and relative peak height (rPH, rPHmax), normalized to white matter. Tumor regions of interest were manually segmented, excluding calcified or hemorrhagic areas. Group comparisons and ROC analyses assessed diagnostic performance of individual and combined parameters. Results: Significant differences in diffusion and perfusion metrics were observed among the five tumor types. The combined analysis of DWI and PWI improved diagnostic accuracy in selected comparisons. The greatest benefit occurred in distinguishing meningiomas from solid non-functional pituitary adenomas (pituitary neuroendocrine tumors-PitNET), where the combination of ADCmin and rPHmax yielded an AUC of 0.818, sensitivity of 88%, and specificity of 76%, exceeding the performance of either parameter alone. In other comparisons, including meningiomas versus invasive PitNETs and adamantinomatous craniopharyngiomas, combined analysis did not substantially improve accuracy when single parameters, particularly rCBVmax (AUC = 0.995), already demonstrated excellent performance. Conclusions: Integration of DWI and PWI into pituitary MRI protocols enhances diagnostic performance in selected tumor groups. The additive value is context-dependent, supporting the tailored application of these sequences in the evaluation of sellar and parasellar tumors.<\/jats:p>","DOI":"10.3390\/jcm14207168","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:12:29Z","timestamp":1760523149000},"page":"7168","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combined Use of Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging in the Differential Diagnosis of Sellar Tumors: A Single-Centre Experience"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-9819","authenticated-orcid":false,"given":"Adrian","family":"Korbecki","sequence":"first","affiliation":[{"name":"Department of General and Interventional Radiology and Neuroradiology, Medical University Hospital, 50-556 Wroclaw, Poland"},{"name":"Hetalox sp. z o.o., 54-105 Wroclaw, Poland"},{"name":"Lower Silesian Specialist Hospital T. Marciniak\u2014Emergency Medicine Center, 54-049 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"\u0141ukasiewicz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2392-6466","authenticated-orcid":false,"given":"Arkadiusz","family":"Kaca\u0142a","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Radiology and Neuroradiology, Medical University Hospital, 50-556 Wroclaw, Poland"},{"name":"Department of Radiology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Soba\u0144ski","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Radiology and Neuroradiology, Medical University Hospital, 50-556 Wroclaw, Poland"},{"name":"Hetalox sp. z o.o., 54-105 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0447-1021","authenticated-orcid":false,"given":"Agata","family":"Zdanowicz-Ratajczyk","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Radiology and Neuroradiology, Medical University Hospital, 50-556 Wroclaw, Poland"},{"name":"Department of Radiology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0042-0082","authenticated-orcid":false,"given":"Karolina","family":"Sza\u0142ata","sequence":"additional","affiliation":[{"name":"Department of Radiology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Dorochowicz","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Radiology and Neuroradiology, Medical University Hospital, 50-556 Wroclaw, Poland"},{"name":"Department of Radiology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Korbecka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-4901","authenticated-orcid":false,"given":"Grzegorz","family":"Trybek","sequence":"additional","affiliation":[{"name":"4th Military Clinical Hospital in Wroclaw, Rudolfa Weigla 5, 50-981 Wroclaw, Poland"},{"name":"Department of Oral Surgery, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zimny","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Radiology and Neuroradiology, Medical University Hospital, 50-556 Wroclaw, Poland"},{"name":"Department of Radiology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-8457","authenticated-orcid":false,"given":"Joanna","family":"Bladowska","sequence":"additional","affiliation":[{"name":"Lower Silesian Specialist Hospital T. Marciniak\u2014Emergency Medicine Center, 54-049 Wroclaw, Poland"},{"name":"Faculty of Medicine, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland"},{"name":"Department of Radiology, 4th Military Clinical Hospital with Polyclinic, Independent Public Healthcare Institution, 50-981 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3171\/2014.5.JNS131819","article-title":"Descriptive Epidemiology of Pituitary Tumors in the United States, 2004\u20132009: Clinical Article","volume":"121","author":"Gittleman","year":"2014","journal-title":"J. Neurosurg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s11604-023-01407-0","article-title":"Imaging of Pituitary Tumors: An Update with the 5th WHO Classifications\u2014Part 2. 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