{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:12:56Z","timestamp":1760526776834,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Screening for late-onset and term preeclampsia (PE) is essential, as the early identification of women at high risk enables closer monitoring and reduces adverse outcomes. The existing algorithms combining maternal factors, biophysical and biochemical markers have not been validated outside the populations in which they were originally developed. This study aimed to evaluate the predictive performance of the Fetal Medicine Foundation (FMF) third-trimester algorithm in our population and develop a novel model to improve the predictions. Methods: An observational, analytical, prospective cohort follow-up study was conducted at the Health Department of Alicante, Dr. Balmis General University Hospital, including 1580 singleton pregnancies recruited between February 2022 and November 2023 during routine third-trimester ultrasounds. Maternal clinical characteristics, blood pressure, the uterine artery pulsatility index (UtA-PI), and the sFlt-1\/PlGF ratio were recorded. The FMF third-trimester algorithm was retrospectively applied at the end of pregnancy using clinical, biophysical, and biochemical data from 30 + 0 to 37 + 6 weeks via the freely accessible online calculator. The data analysis was performed using SPSS v.28 and R v.4.3.1. Results: A total of 1580 women were included, with a prevalence of late-onset PE of 2.9%. The FMF model achieved an area under the curve (AUC) of 0.87 (95% CI: 0.81\u20130.92), while our own model showed a superior performance, with an AUC of 0.94 (95% CI: 0.92\u20130.97). Conclusions: The FMF third-trimester algorithm demonstrated a good predictive performance for late-onset PE. Our newly developed model achieves an even higher predictive accuracy and offers a simplified approach to excluding the UtA-PI, which facilitates its use in routine clinical practice.<\/jats:p>","DOI":"10.3390\/jcm14207185","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:12:29Z","timestamp":1760523149000},"page":"7185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A New Model for Screening for Late-Onset Preeclampsia in the Third Trimester"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-3922","authenticated-orcid":false,"given":"Clara","family":"Jim\u00e9nez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Dr. Balmis General University Hospital, 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-4453","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Palacios-Marqu\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Dr. Balmis General University Hospital, 03010 Alicante, Spain"},{"name":"Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain"},{"name":"Department of Public Health, History of Science and Gynecology, Miguel Hern\u00e1ndez University, 03550 San Juan de Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-7531","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Quesada-Rico","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Miguel Hern\u00e1ndez University, 03550 San Juan de Alicante, Spain"},{"name":"Network for Research on Chronicity, Primary Care and Health Promotion (RICAPPS), 03550 San Juan de Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Baviera-Royo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Dr. Balmis General University Hospital, 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Encarnaci\u00f3n","family":"P\u00e9rez-Pascual","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Dr. Balmis General University Hospital, 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Bald\u00f3-Estela","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Dr. Balmis General University Hospital, 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5546-5052","authenticated-orcid":false,"given":"V\u00edctor","family":"Garc\u00eda-Sousa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Dr. Balmis General University Hospital, 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","article-title":"Pre-Eclampsia","volume":"398","author":"Chappell","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMra2109523","article-title":"Preeclampsia","volume":"386","author":"Magee","year":"2022","journal-title":"N. 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