{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:09:53Z","timestamp":1791976193329,"version":"4.4.0"},"reference-count":44,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008795","name":"Manitoba Medical Service Foundation","doi-asserted-by":"crossref","award":["#2021-11"],"award-info":[{"award-number":["#2021-11"]}],"id":[{"id":"10.13039\/100008795","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Centre on Aging"},{"name":"University of Manitoba Research Fellowship"},{"name":"University of Manitoba Retirees Association Scholarship"},{"name":"Center on Aging Betty Havens Memorial Graduate Fellowship"},{"name":"Jack MacDonell Scholarship for Research in Aging"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The cardiovascular system of older adults is significantly impacted by aging, contributing to blood pressure (BP) dysregulation, particularly during postural transitions. This study compared the short-term cardiovascular compensatory responses of younger adults (YA) and older adults (OA) during sit-to-stand and lie-to-stand. Methods: Participants underwent two active standing orthostatic stress tests, involving 5 min of sitting or 10 min of lying, followed by up to 7 min of standing. Beat-to-beat cardiovascular parameters were assessed using a Finometer (Finapres Medical Systems). Systolic (SBP), diastolic (DBP), mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV), systemic vascular resistance (SVR), and HR were measured at baseline, immediately on standing, and throughout four specific phases after standing: phase 1 (0\u201330 s), phase 2 (30\u201360 s), phase 3 (60\u201380 s), and phase 4 (300\u2013420 s). CO-SVR matching was evaluated to assess BP regulation timing. Results: Compared to YA, OA exhibited higher SBP, DBP, MAP, and SVR but lower HR, CO, and SV at baseline. Immediately on standing, OA experienced a greater drop in SBP, DBP, MAP, and SVR, blunted HR, reduced CO, and higher SV. The short-term compensatory responses were delayed (30\u201360 s), particularly in lie-to-stand, due to a transient CO and SVR mismatch observed in phase 1 and subsequent BP stabilization from phases 2\u20134. Conclusions: OA exhibited short-term compensatory cardiovascular dysregulation, particularly during the transition from a lying to a standing position.<\/jats:p>","DOI":"10.3390\/jcm14207202","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:12:29Z","timestamp":1760523149000},"page":"7202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Short-Term Cardiovascular Compensatory Responses to Varying Levels of Orthostatic Stress During Active Standing in Older Adults"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-8527","authenticated-orcid":false,"given":"Dihogo Gama","family":"de Matos","sequence":"first","affiliation":[{"name":"Cardiorespiratory & Physiology of Exercise Research Laboratory, Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-731X","authenticated-orcid":false,"given":"Jefferson Lima","family":"de Santana","sequence":"additional","affiliation":[{"name":"Cardiorespiratory & Physiology of Exercise Research Laboratory, Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7378-4529","authenticated-orcid":false,"given":"Felipe J.","family":"Aidar","sequence":"additional","affiliation":[{"name":"Graduate Program in Physical Education and Kinesiology and Physiological Sciences, Federal University of Sergipe, Sao Cristovao 49100-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-6707","authenticated-orcid":false,"given":"Stephen M.","family":"Cornish","sequence":"additional","affiliation":[{"name":"Centre on Aging, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon G.","family":"Giesbrecht","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Departments of Anesthesia and Emergency Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-3124","authenticated-orcid":false,"given":"Alben\u00e1","family":"Nunes-Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation and Exercise Immunology, Department of Physical Education, School of Physical Education, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-3785","authenticated-orcid":false,"given":"Satish R.","family":"Raj","sequence":"additional","affiliation":[{"name":"Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-7447","authenticated-orcid":false,"given":"Roman","family":"Romero-Ortuno","sequence":"additional","affiliation":[{"name":"Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-4800","authenticated-orcid":false,"given":"Todd A.","family":"Duhamel","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Institute of Cardiovascular Sciences, St. Boniface General Hospital Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-3346","authenticated-orcid":false,"given":"Rodrigo","family":"Villar","sequence":"additional","affiliation":[{"name":"Cardiorespiratory & Physiology of Exercise Research Laboratory, Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Centre on Aging, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105894","DOI":"10.1016\/j.archger.2025.105894","article-title":"Cardiovascular Regulation during Active Standing Orthostatic Stress in Older Adults Living with Frailty: A Systematic Review","volume":"136","author":"Aidar","year":"2025","journal-title":"Arch. 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