{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:11:35Z","timestamp":1789168295593,"version":"build-2803163510"},"reference-count":39,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Oradea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Few studies have comprehensively examined dental anomalies in adolescents with genetic syndromes. This study aimed to assess their prevalence, types, and clinical patterns in a diverse sample of genetically confirmed cases. Methods: We conducted a retrospective cross-sectional study of 213 patients aged 12 to 18 years with various genetic syndromes, using clinical data originally collected between 2011 and 2014 at a tertiary center. Clinical examinations were complemented by radiographs when available. Anomalies were categorized by type, and a disproportionality analysis (Rate of Occurrence Ratio, ROR) quantified risk relative to syndrome representation. Results: Dental anomalies were present in 68% of adolescents. The most common findings were hypodontia, taurodontism (9%), and enamel hypoplasia (8%). Nearly half of the patients exhibited combined patterns, with hypodontia\u2013taurodontism as the most characteristic combination (14%). Prevalence was particularly high in trisomy-based (80%) and osteogenesis-related (100%) syndromes. Down syndrome showed the strongest association (ROR 3.95; 95% CI: 2.15\u20137.25), while some conditions such as Turner, Ehlers-Danlos, and Tuberous sclerosis displayed significantly lower rates. Conclusions: Dental anomalies are both highly prevalent and patterned in adolescents with genetic syndromes. Their co-occurrence and specificity suggest that they may serve as useful diagnostic markers in syndromic evaluation.<\/jats:p>","DOI":"10.3390\/jcm14207217","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:57:42Z","timestamp":1760529462000},"page":"7217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oral Manifestations in Adolescents with Genetic Syndromes: A Retrospective Cross-Sectional Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Adriana","family":"\u021aen\u021b","sequence":"first","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and Pharmacy, University of Oradea, 4 Universit\u0103\u021bii Street, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Iurcov","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and Pharmacy, University of Oradea, 4 Universit\u0103\u021bii Street, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7275-9986","authenticated-orcid":false,"given":"Abel Emanuel","family":"Moca","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and Pharmacy, University of Oradea, 4 Universit\u0103\u021bii Street, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-9932","authenticated-orcid":false,"given":"Rahela Tabita","family":"Moca","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and Pharmacy, University of Oradea, 4 Universit\u0103\u021bii Street, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4897-9321","authenticated-orcid":false,"given":"Ioan Andrei","family":"\u021aig","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and Pharmacy, University of Oradea, 4 Universit\u0103\u021bii Street, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra Ilinca","family":"Matei","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and Pharmacy, University of Oradea, 4 Universit\u0103\u021bii Street, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"ref_1","unstructured":"(2025, July 15). 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