{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:01Z","timestamp":1787028661091,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), serves as a major complication in critically ill patients receiving extracorporeal life support (ECLS). The primary aim of the study was to systematically determine the prevalence of cannula-associated DVT following ECLS in a mixed adult ICU population. Methods: In this prospective diagnostic study, performed at two ICUs at a tertiary university hospital, we included 101 patients undergoing ECLS between 2016 and 2021. DVT was assessed by vascular ultrasound within 72 h after decannulation or through post-mortem examination. PE was identified by computed tomography when clinically indicated or through post-mortem examination. Both univariate analysis and multivariable logistic regression were used to evaluate risk factors. Results: The overall prevalence of DVT was 35%, and PE was found in 9% of patients. PE was significantly more frequent in patients with DVT compared to those without DVT (23% vs. 2%, p &lt; 0.001). Logistic regression suggests venovenous configuration as an independent risk factor for DVT compared with venoarterial ECLS (OR = 0.12, 95% CI: 0.04\u20130.39, p = 0.0004). There were no significant differences in coagulation parameters, including anticoagulation target values, in patients with and without DVT. Conclusions: This study reveals a considerable prevalence of DVT in patients following ECLS, with VV configuration emerging as a considerable risk factor. PE was common, underscoring the need for routine screening protocols and tailored thromboprophylaxis in this population.<\/jats:p>","DOI":"10.3390\/jcm14207241","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:57:42Z","timestamp":1760529462000},"page":"7241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cannula-Associated Deep Vein Thrombosis After Extracorporeal Life Support: A Prospective Diagnostic Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-7884","authenticated-orcid":false,"given":"Alexander","family":"Hermann","sequence":"first","affiliation":[{"name":"Intensive Care Unit 13i2, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannis","family":"Krais","sequence":"additional","affiliation":[{"name":"Intensive Care Unit 13i2, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maria","family":"Tremetsberger","sequence":"additional","affiliation":[{"name":"Intensive Care Unit 13i2, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Ristl","sequence":"additional","affiliation":[{"name":"Center for Medical Data Science, Medical University of Vienna, Spitalgasse 23, BT88, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-0713","authenticated-orcid":false,"given":"Johannes Philipp","family":"Klaeger","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2286-1077","authenticated-orcid":false,"given":"Christian","family":"Schoergenhofer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Buchtele","sequence":"additional","affiliation":[{"name":"Intensive Care Unit 13i2, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0639-8542","authenticated-orcid":false,"given":"Bernhard","family":"Nagler","sequence":"additional","affiliation":[{"name":"Intensive Care Unit 13i2, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schellongowski","sequence":"additional","affiliation":[{"name":"Intensive Care Unit 13i2, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3238-194X","authenticated-orcid":false,"given":"Oliver","family":"Robak","sequence":"additional","affiliation":[{"name":"Intensive Care Unit 13i2, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra-Maria","family":"Stommel","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-4473","authenticated-orcid":false,"given":"Thomas","family":"Staudinger","sequence":"additional","affiliation":[{"name":"Intensive Care Unit 13i2, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"ref_1","first-page":"2683555241297566","article-title":"Prevalence and risk factors of hospital acquired venous 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