{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:41:28Z","timestamp":1760575288925,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: In polycystic kidney diseases, increased periostin levels and disease progression are observed. Multicystic dysplastic kidney (MCDK) is characterized by kidney atrophy. The aim of the study is to assess serum periostin activity in children with MCDK and in patients with MCDK and involution of cysts. Methods: We enrolled in the study 64 children aged 1\u20135 years (mean age 25 +\/\u2212 9 months). Serum periostin (sPOSTN) levels were measured using enzyme-linked immunosorbent assay. We divided children into three groups: group A\u2014patients with MCDK and cysts (n = 34); group B\u2014patients with involution of cysts or after nephrectomy (n = 10), and group C\u2014healthy children (n = 20). Results: Blood samples were obtained from 64 children, including 44 children with MCDK (26 boys, 18 girls). sPOSTN levels were significantly higher in group A, 239.1 \u00b1 168.1 [IQR: 62.4, 385.7] ng\/mL, compared to group B, 77.7 \u00b1 82.8 [IQR: 31.7, 117.0] ng\/mL (p &lt; 0.05). The median level of periostin in patients with MCDK (groups A and B) was 204.4 \u00b1 168.2 [IQR: 34.9, 363.4] ng\/mL and 141.1 \u00b1 129.0 [IQR: 30.3, 276.9] ng\/mL in group C, respectively. In patients with the renal cysts, the cut-off value of periostin was 133.57 ng\/mL. The lowest level of periostin was observed in patients in group B. There were no significant differences in periostin level between groups B and C. Conclusions: The study shows that a high level of sPOSTN was identified in patients with MCDK and cyst presentation in abdominal ultrasonography. The level of sPOSTN could be a promising blood marker of the cyst\u2019s formation in cystic kidney diseases. However, this study remains preliminary; further studies are needed to confirm our findings.<\/jats:p>","DOI":"10.3390\/jcm14207264","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:57:42Z","timestamp":1760529462000},"page":"7264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Value of Serum Periostin for Cyst Involution in Children with Multicystic Dysplastic Kidney"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-4160","authenticated-orcid":false,"given":"Agnieszka","family":"Szmigielska","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Kotu\u0142a","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Demkow","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Szmigielska","sequence":"additional","affiliation":[{"name":"Student Scientific Group, Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Tutka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sekine, A., Hidaka, S., Moriyama, T., Shikida, Y., Shimazu, K., Ishikawa, E., Uchiyama, K., Kataoka, H., Kawano, H., and Kurashige, M. 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