{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:01:31Z","timestamp":1792155691055,"version":"4.4.0"},"reference-count":52,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and ICT of Korea","award":["RS-2024-00393728"],"award-info":[{"award-number":["RS-2024-00393728"]}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea","doi-asserted-by":"crossref","award":["2023IP0101"],"award-info":[{"award-number":["2023IP0101"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously referred to as NAFLD, affects nearly one-third of the global adult population and is a leading cause of chronic liver disease, particularly among individuals with obesity and type 2 diabetes (T2DM). Bariatric surgery, including sleeve gastrectomy (SG), has demonstrated a favorable impact on liver fat reduction. However, the predictive value of early postoperative weight-loss trajectories for long-term hepatic improvement remains uncertain, especially in Asian populations, in which MASLD remains understudied despite its increasing prevalence. Methods: We retrospectively reviewed 198 adults who underwent SG at a tertiary Korean center between January 2019 and April 2024. After excluding 21 who had postoperative complications or missed early follow-up, 177 patients (mean age 37 \u00b1 9 years; 41% male; mean body mass index (BMI) 40 kg\/m2) were included in the final analysis. The two-week total weight-loss index (TWL_2W) was calculated, and its association with one-year hepatic steatosis resolution, defined as the normalization of the hepatic steatosis index (HSI &lt; 30) at one year, was assessed using receiver operating characteristic (ROC) analysis to explore the trend toward predictive value. Optimal cut-offs were derived using the Youden Index. Multivariable logistic regression models were adjusted for age, sex, baseline hemoglobin A1c (HbA1c), and BMI. Subgroup analyses were performed according to baseline HSI (35\u201344, 45\u201354, \u226555) and type 2 diabetes mellitus (T2DM) status. Results: The mean TWL_2W was 7.9 \u00b1 6.6%. A loss of 7.9% optimally predicted HSI values &lt; 30 at one year (area under the curve [AUC] 0.602; unadjusted odds ratio [OR] 2.34; 95% confidence interval [CI] 1.16\u20134.73). Predictive accuracy improved in T2DM patients (AUC 0.737, 95% CI 0.54\u20130.95), in whom TWL_2W \u2265 9.1% conferred an adjusted OR 9.12 (95% CI 1.39\u201359.82), whereas no association was observed in non-diabetic subjects. Stratified analysis showed a pronounced effect in moderate baseline steatosis (HSI 45\u201354; OR 3.56), but absolute normalization was rare when the baseline HSI was \u226555. Early weight loss was not significantly linked to one-year HbA1c or triglyceride targets. Conclusions: An 8\u20139% reduction in body weight within two weeks of SG was independently associated with the resolution of hepatic steatosis at one year, particularly among patients with T2DM or moderate baseline hepatic steatosis. This simple metric may assist in early risk stratification and guide personalized postoperative care.<\/jats:p>","DOI":"10.3390\/jcm14207284","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:04:02Z","timestamp":1760537042000},"page":"7284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Rapid Early Weight Loss with One-Year Hepatic Steatosis Improvement After Sleeve Gastrectomy: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Min Kyoung","family":"Jang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Yeol","family":"Yoon","sequence":"additional","affiliation":[{"name":"University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin A.","family":"An","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-0390","authenticated-orcid":false,"given":"Min-Seon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ah","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Seok","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Stomach Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Hee","family":"Min","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","article-title":"Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults","volume":"403","author":"Phelps","year":"2024","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.2337\/dc23-0294","article-title":"Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study","volume":"46","author":"Brown","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1007\/s40618-024-02368-5","article-title":"The impact of overweight on lipid phenotype in different forms of dyslipidemia: A retrospective cohort study","volume":"47","author":"Formisano","year":"2024","journal-title":"J. Endocrinol. Investig."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): A systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1136\/gutjnl-2021-325724","article-title":"Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: Results from a nationwide histology cohort","volume":"71","author":"Simon","year":"2022","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/dc17-1902","article-title":"Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis","volume":"41","author":"Mantovani","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wei, L., Li, M., Zeng, N., Liu, Y., Bai, R., Zhang, N., Song, J., Zhang, P., Yao, Q., and Yang, Z. (2021). Bariatric surgery for non-alcoholic fatty liver disease in individuals with obesity (Base-NAFLD): Protocol of a prospective multicenter observational follow-up study. BMC Surg., 21.","DOI":"10.1186\/s12893-021-01296-y"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.soard.2022.08.013","article-title":"2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): Indications for Metabolic and Bariatric Surgery","volume":"18","author":"Eisenberg","year":"2022","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2024). 8. Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes: Standards of Care in Diabetes\u20142025. Diabetes Care, 48, S167\u2013S180.","DOI":"10.2337\/dc25-S008"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1007\/s11695-024-07196-3","article-title":"Metabolic Bariatric Surgery Across the IFSO Chapters: Key Insights on the Baseline Patient Demographics, Procedure Types, and Mortality from the Eighth IFSO Global Registry Report","volume":"34","author":"Brown","year":"2024","journal-title":"Obes. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100836","DOI":"10.1016\/j.lanepe.2024.100836","article-title":"Long-term effect of sleeve gastrectomy vs Roux-en-Y gastric bypass in people living with severe obesity: A phase III multicentre randomised controlled trial (SleeveBypass)","volume":"38","author":"Biter","year":"2024","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1007\/s11695-022-06166-x","article-title":"Early Postoperative Weight Loss Predicts Weight Loss up to 5 Years After Roux-En-Y Gastric Bypass, Banded Roux-En-Y Gastric Bypass, and Sleeve Gastrectomy","volume":"32","author":"Tettero","year":"2022","journal-title":"Obes. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1007\/s00464-014-3829-7","article-title":"Early postoperative weight loss predicts maximal weight loss after sleeve gastrectomy and Roux-en-Y gastric bypass","volume":"29","author":"Manning","year":"2015","journal-title":"Surg. Endosc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1053\/j.gastro.2020.06.006","article-title":"Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis","volume":"159","author":"Lassailly","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11695-024-07071-1","article-title":"Mid-term Effects of Bariatric Surgery on Metabolic Dysfunction-Associated Fatty Liver Disease Remission and Predictive Factors: A Prospective Study with a Focus on Non-invasive Diagnosis","volume":"34","author":"Mestres","year":"2024","journal-title":"Obes. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101255","DOI":"10.1016\/j.diabet.2021.101255","article-title":"Early continuous glucose monitoring for predicting remission of type 2 diabetes 1 year after bariatric surgery","volume":"47","author":"Turquetil","year":"2021","journal-title":"Diabetes Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/dom.12971","article-title":"Effect of weight reduction on glycated haemoglobin in weight loss trials in patients with type 2 diabetes","volume":"19","author":"Gummesson","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1161\/HYPERTENSIONAHA.120.15026","article-title":"2020 International Society of Hypertension Global Hypertension Practice Guidelines","volume":"75","author":"Unger","year":"2020","journal-title":"Hypertension"},{"key":"ref_21","first-page":"e596","article-title":"2019 ACC\/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"140","author":"Arnett","year":"2019","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)","volume":"41","author":"Mach","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2024). 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes\u20142025. Diabetes Care, 48, S27\u2013S49.","DOI":"10.2337\/dc25-S002"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), and European Association for the Study of Obesity (EASO) (2016). EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease. Obes. Facts, 9, 65\u201390.","DOI":"10.1159\/000443344"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3350\/cmh.2021.0178","article-title":"KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease","volume":"27","author":"Kang","year":"2021","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.dld.2009.08.002","article-title":"Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease","volume":"42","author":"Lee","year":"2010","journal-title":"Dig. Liver Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection","volume":"43","author":"Sterling","year":"2006","journal-title":"Hepatology"},{"key":"ref_28","first-page":"1212","article-title":"Liver Fat Scores for Noninvasive Diagnosis and Monitoring of Nonalcoholic Fatty Liver Disease in Epidemiological and Clinical Studies","volume":"11","author":"Reinshagen","year":"2023","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Song, K., Kwon, Y.J., Lee, E., Lee, H.S., Youn, Y.H., Baik, S.J., Shin, H.J., and Chae, H.W. (Clin. Gastroenterol. Hepatol., 2025). Optimal Cutoffs of Fatty Liver Index and Hepatic Steatosis Index in Diagnosing Pediatric Metabolic Dysfunction-Associated Steatotic Liver Disease, Clin. Gastroenterol. Hepatol., online ahead of print.","DOI":"10.1016\/j.cgh.2025.06.011"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.12997\/jla.2023.12.1.12","article-title":"Lipid Management in Korean People With Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement","volume":"12","author":"Yang","year":"2023","journal-title":"J. Lipid Atheroscler."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","article-title":"Mitochondrial alterations in fatty liver diseases","volume":"78","author":"Fromenty","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/hep.32324","article-title":"Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD","volume":"76","author":"Moore","year":"2022","journal-title":"Hepatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"111016","DOI":"10.1016\/j.diabres.2023.111016","article-title":"Insulin resistance and metabolic flexibility as drivers of liver and cardiac disease in T2DM","volume":"206","author":"Colosimo","year":"2023","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/SLA.0000000000003671","article-title":"Laparoscopic Sleeve Gastrectomy Versus Laparoscopic Roux-en-Y Gastric Bypass: A Systematic Review and Meta-analysis of Weight Loss, Comorbidities, and Biochemical Outcomes From Randomized Controlled Trials","volume":"273","author":"Lee","year":"2021","journal-title":"Ann. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.soard.2017.05.016","article-title":"Early weight loss after laparoscopic sleeve gastrectomy predicts midterm weight loss in morbidly obese Asians","volume":"13","author":"Chew","year":"2017","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1007\/s11695-023-06527-0","article-title":"Prediction of 5-Year Weight Loss and Weight Regain According to Early Weight Loss after Sleeve Gastrectomy","volume":"33","author":"Su","year":"2023","journal-title":"Obes. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"33173","DOI":"10.1038\/s41598-025-17320-7","article-title":"Early prediction of suboptimal clinical response after bariatric surgery using total weight loss percentiles","volume":"15","author":"Boustani","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Tasabehji, D., Saleh, S., and Mokadem, M. (2025). Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review. J. Clin. Med., 14.","DOI":"10.3390\/jcm14124012"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"S276","DOI":"10.3350\/cmh.2022.0373","article-title":"Bariatric surgery for non-alcoholic fatty liver disease: Indications and post-operative management","volume":"29","author":"Geerts","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/s41598-025-85427-y","article-title":"Impact of bariatric surgery on liver fibrosis indices among type 2 diabetes patients in a national cohort","volume":"15","author":"Seyedi","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.soard.2019.09.060","article-title":"Systematic review and meta-analysis of Roux-en-Y gastric bypass against laparoscopic sleeve gastrectomy for amelioration of NAFLD using four criteria","volume":"15","author":"Baldwin","year":"2019","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41387-019-0100-2","article-title":"Energy restriction in obese women suggest linear reduction of hepatic fat content and time-dependent metabolic improvements","volume":"9","author":"Johansson","year":"2019","journal-title":"Nutr. Diabetes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2337\/dc15-1942","article-title":"Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders","volume":"39","author":"Steven","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2018.07.003","article-title":"Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for \u03b2 Cell Recovery","volume":"28","author":"Taylor","year":"2018","journal-title":"Cell Metab."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1007\/s00125-011-2204-7","article-title":"Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol","volume":"54","author":"Lim","year":"2011","journal-title":"Diabetologia"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S2213-8587(19)30076-2","article-title":"Understanding the mechanisms of reversal of type 2 diabetes","volume":"7","author":"Taylor","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Tu, J., Wang, Y., Jin, L., and Huang, W. (2022). Bile acids, gut microbiota and metabolic surgery. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.929530"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nevola, R., Epifani, R., Imbriani, S., Tortorella, G., Aprea, C., Galiero, R., Rinaldi, L., Marfella, R., and Sasso, F.C. (2023). GLP-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: Current Evidence and Future Perspectives. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021703"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Katafuchi, T., and Makishima, M. (2022). Molecular Basis of Bile Acid-FXR-FGF15\/19 Signaling Axis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116046"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105265","DOI":"10.1016\/j.ebiom.2024.105265","article-title":"Alterations in bile acid kinetics after bariatric surgery in patients with obesity with or without type 2 diabetes","volume":"106","author":"Aydin","year":"2024","journal-title":"EBioMedicine"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Huang, H.H., Lee, W.J., Chen, S.C., Chen, T.F., Lee, S.D., and Chen, C.Y. (2019). Bile Acid and Fibroblast Growth Factor 19 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Sleeve Gastrectomy. J. Clin. Med., 8.","DOI":"10.3390\/jcm8060815"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e174233","DOI":"10.1172\/JCI174233","article-title":"Weight loss in MASLD restores the balance of liver fatty acid sources","volume":"135","author":"Lambert","year":"2025","journal-title":"J. Clin. Investig."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/20\/7284\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T04:36:48Z","timestamp":1760762208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/20\/7284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":52,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["jcm14207284"],"URL":"https:\/\/doi.org\/10.3390\/jcm14207284","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]}}}