{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:28:09Z","timestamp":1771615689710,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key R&D Program of the Department of Science and Technology of Sichuan Province","award":["2024YFHZ0057"],"award-info":[{"award-number":["2024YFHZ0057"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: We aimed to explore the efficacy of repetitive transcranial magnetic stimulation (rTMS) for idiopathic sudden sensorineural hearing loss (ISSNHL) and evaluate the correlation between treatment courses of rTMS and hearing outcomes. Methods: A prospective observational study was conducted at West China Fourth Hospital, Sichuan University, from January 2018 to January 2025. The study enrolled 339 patients (342 affected ears) diagnosed with ISSNHL. Among them, 67 patients (group A) received standard therapy combined with rTMS, while the control group (group B) received conventional therapy only. To verify the correlation between different treatment courses of rTMS and hearing outcomes, patients in Group A were divided into Group A1 (treatment courses \u2264 10) and Group A2 (treatment courses &gt; 10). Hearing thresholds and clinical characteristics were evaluated at admission, discharge day and 6 months post-treatment. The SDRG\u2019s criteria were used for the grading of hearing recovery. Results: Tinnitus (79.89% vs. 75.32%, p = 0.361) and sleep disorders (33.70% vs. 41.14%, p = 0.178) were highly prevalent among patients in group A and group B. 1 Hz rTMS significantly improved these symptoms (PSQI: 52.32% vs. 44.44%, p = 0.032; THI: 16.67 \u00b1 19.41 vs. 8.22 \u00b1 12.77, p = 0.002). Compared to high-tone hearing loss patients, those with low-tone loss in groupA2 showed a more rapid improvement (250 Hz: 17.66 \u00b1 16.59 vs. 14.09 \u00b1 15.58, p = 0.041; 500 Hz: 21.20 \u00b1 18.03 vs. 17.31 \u00b1 16.24, p = 0.036) than grouA1, with benefits sustained at 6-month follow-up (250 Hz: 27.79 \u00b1 18.74 vs. 22.71 \u00b1 18.31, p = 0.012; 500 Hz: 31.89 \u00b1 19.73 vs. 26.49 \u00b1 20.08, p = 0.013). Conclusions: rTMS at 1 Hz, administered in courses &gt; 10 sessions, demonstrated both short-term and long-term beneficial effects in the ISSNHL. Those with low-tone hearing loss exhibit better recovery but a higher chance of relapse than high-tone loss patients. As a non-invasive approach with minimal side effects, rTMS is suitable for routine ISSNHL treatment.<\/jats:p>","DOI":"10.3390\/jcm14207369","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:27:29Z","timestamp":1760963249000},"page":"7369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Characteristics and Correlation of Hearing Outcomes Following Varying Courses of Repetitive Transcranial Magnetic Stimulation for Idiopathic Sudden Sensorineural Hearing Loss: A Prospective Clinical Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0850-7442","authenticated-orcid":false,"given":"Chao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine and Neurology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8322-7355","authenticated-orcid":false,"given":"Junming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0140-6736(09)62071-7","article-title":"Sudden sensorineural hearing loss","volume":"375","author":"Schreiber","year":"2010","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1177\/0194599812436449","article-title":"Clinical practice guideline: Sudden hearing loss","volume":"146","author":"Stachler","year":"2012","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_3","first-page":"S1","article-title":"Clinical Practice Guideline: Sudden Hearing Loss (Update)","volume":"161","author":"Chandrasekhar","year":"2019","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MAO.0b013e31819d3496","article-title":"Recurrence rate of idiopathic sudden low-tone sensorineural hearing loss without vertigo: A long-term follow-up study","volume":"30","author":"Fushiki","year":"2009","journal-title":"Otol. Neurotol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/MAO.0000000000001361","article-title":"Combined Intratympanic and Systemic Use of Steroids as a First-Line Treatment for Sudden Sensorineural Hearing Loss: A Meta-Analysis of Randomized, Controlled Trials","volume":"38","author":"Han","year":"2017","journal-title":"Otol. Neurotol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhang, D., and Ma, Y. (2015). Repetitive transcranial magnetic stimulation improves both hearing function and tinnitus perception in sudden sensorineural hearing loss patients. Sci. Rep., 5.","DOI":"10.1038\/srep14796"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.clinph.2019.05.022","article-title":"Steady-state auditory evoked fields reflect long-term effects of repetitive transcranial magnetic stimulation in tinnitus","volume":"130","author":"Li","year":"2019","journal-title":"Clin. Neurophysiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.5152\/iao.2023.22801","article-title":"Short-Term Effect of Adjunctive Transcranial Random Noise Stimulation on Idiopathic Sudden Sensorineural Hearing Loss and Tinnitus: A Preliminary Study","volume":"19","author":"Shin","year":"2023","journal-title":"J. Int. Adv. Otol."},{"key":"ref_9","first-page":"237","article-title":"Theta, alpha and beta burst transcranial magnetic stimulation: Brain modulation in tinnitus","volume":"4","author":"Menovsky","year":"2007","journal-title":"Int. J. Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.clinph.2014.05.021","article-title":"Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)","volume":"125","author":"Lefaucheur","year":"2014","journal-title":"Clin. Neurophysiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/MAO.0b013e31816569c4","article-title":"Development and psychometric adequacy of the screening version of the tinnitus handicap inventory","volume":"29","author":"Newman","year":"2008","journal-title":"Otol. Neurotol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Committee on Hearing and Equilibrium Guidelines for the Diagnosis and Evaluation of Therapy in Meni\u00e8re\u2019s Disease (1995). American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngol. Head Neck Surg., 113, 181\u2013185.","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"ref_13","first-page":"11","article-title":"The World Health Organization\u2019s Programme for the Prevention of Deafness and Hearing Impairment","volume":"45","author":"Smith","year":"1997","journal-title":"Scand. Audiol. Suppl."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/00016488809125074","article-title":"Evaluation of hearing recovery and efficacy of steroid treatment in sudden deafness","volume":"456","author":"Kanzaki","year":"1988","journal-title":"Acta Otolaryngol. Suppl."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/019459988309100612","article-title":"Viral and epidemiologic studies of idiopathic sudden hearing loss","volume":"91","author":"Wilson","year":"1983","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Danielides, V., Nousia, C.S., Bartzokas, A., Lolis, C.J., Kateri, M., and Skevas, A. (2002). Weather conditions and sudden sensorineural hearing loss. BMC Ear Nose Throat Disord., 2.","DOI":"10.1186\/1472-6815-2-2"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00234-007-0255-8","article-title":"Lateralization of neural activity associated with tinnitus","volume":"49","author":"Folmer","year":"2007","journal-title":"Neuroradiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MAO.0b013e31827b4d46","article-title":"Repetitive transcranial magnetic stimulation as a treatment for chronic tinnitus: A critical review","volume":"34","author":"Theodoroff","year":"2013","journal-title":"Otol. Neurotol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3342\/ceo.2013.6.2.63","article-title":"Short term effects of repetitive transcranial magnetic stimulation in patients with catastrophic intractable tinnitus: Preliminary report","volume":"6","author":"Lee","year":"2013","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0079-6123(07)66008-7","article-title":"Functional imaging of chronic tinnitus: The use of positron emission tomography","volume":"166","author":"Eichhammer","year":"2007","journal-title":"Prog. Brain Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neucli.2011.12.001","article-title":"Navigated rTMS for the treatment of tinnitus: A pilot study with assessment by fMRI and AEPs","volume":"42","author":"Lefaucheur","year":"2012","journal-title":"Neurophysiol. Clin."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.brs.2012.10.005","article-title":"Hearing safety of long-term treatment with theta burst stimulation","volume":"6","author":"Schraven","year":"2013","journal-title":"Brain Stimul."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4081\/audiores.2017.168","article-title":"A Retrospective Study of the Clinical Characteristics and Post-treatment Hearing Outcome in Idiopathic Sudden Sensorineural Hearing Loss","volume":"7","author":"Ganesan","year":"2017","journal-title":"Audiol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1468-1331.2010.02965.x","article-title":"Contralateral versus ipsilateral rTMS of temporoparietal cortex for the treatment of chronic unilateral tinnitus: Comparative study","volume":"17","author":"Khedr","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bjorl.2015.07.012","article-title":"Variables with prognostic value in the onset of idiopathic sudden sensorineural hearing loss","volume":"81","author":"Bogaz","year":"2015","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_26","first-page":"238","article-title":"Efficacy of repetitive transcranial magnetic stimulation for the treatment of refractory chronic tinnitus: A randomized, placebo controlled study","volume":"31","author":"Martin","year":"2010","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.otohns.2007.12.022","article-title":"Combined temporal and prefrontal transcranial magnetic stimulation for tinnitus treatment: A pilot study","volume":"138","author":"Kleinjung","year":"2008","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2010.12.002","article-title":"Dysregulation of limbic and auditory networks in tinnitus","volume":"69","author":"Leaver","year":"2011","journal-title":"Neuron"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1176\/appi.ajp.159.7.1093","article-title":"Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders","volume":"159","author":"Hoffman","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1136\/jnnp.2009.188482","article-title":"Therapeutic role of rTMS on recovery of dysphagia in patients with lateral medullary syndrome and brainstem infarction","volume":"81","author":"Khedr","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/20\/7369\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:06:09Z","timestamp":1760965569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/20\/7369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,18]]},"references-count":30,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["jcm14207369"],"URL":"https:\/\/doi.org\/10.3390\/jcm14207369","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,18]]}}}