{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:48:43Z","timestamp":1785800923388,"version":"3.56.0"},"reference-count":38,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Mother\u2019s Memorial Hospital Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Placental thickness has been associated with adverse perinatal outcomes, but the relationship to specific fetal abnormalities seems to not yet be well understood. This study investigates whether increased placental thickness correlates with the severity of fetal cardiac and extracardiac conditions using a structured classification and severity-weighted scoring system. Methods: We undertook a retrospective analysis of 1452 fetal echocardiograms conducted during the third trimester at a tertiary referral institution from the years 2022 to 2025. The diagnoses were categorized into four distinct classifications: congenital heart anomalies, cardiac dysfunctions, extracardiac malformations, and extracardiac dysfunctions. Each diagnostic category was allocated a severity weight predicated on established fetal and neonatal mortality risk literature. The evaluation of placental thickness was regarded not merely as a persistent variable but also categorized into three distinct classifications: thin (\u226440 mm), intermediate (41\u201369 mm), and thick (\u226570 mm). The examination of correlations was performed utilizing Spearman\u2019s \u03c1; comparative evaluations among the groups were conducted employing the Kruskal\u2013Wallis and Mann\u2013Whitney U tests. Results: Placental thickness revealed a moderate positive correlation with weighted extracardiac dysfunctions (\u03c1 = 0.36, p &lt; 0.00001), displayed a comparatively weaker yet statistically significant association with cardiac dysfunctions (\u03c1 = 0.13, p = 0.01). Fetuses identified by increased placental thickness (\u226570 mm) exhibited notably higher mean scores for both cardiac and extracardiac dysfunctions. Within the cohort exhibiting thick placentas, 25.8% displayed extracardiac dysfunction scores surpassing 0.3, in contrast to only 7.7% within the cohort with thinner placentas. Conclusions: Augmented placental thickness correlates with an elevated cumulative load of fetal dysfunction, especially in the realms of extracardiac and functional cardiac impairments. The measurement of placental thickness may function as a straightforward, supplementary indicator of fetal distress in the third trimester, particularly when utilized alongside targeted imaging modalities.<\/jats:p>","DOI":"10.3390\/jcm14217461","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:20:44Z","timestamp":1761196844000},"page":"7461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Placental Thickness Correlates with Severity-Weighted Fetal Dysfunction in the Third Trimester"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-4585","authenticated-orcid":false,"given":"Julia","family":"Murlewska","sequence":"first","affiliation":[{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Sylwestrzak","sequence":"additional","affiliation":[{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"},{"name":"Department of Obstetrics and Gynecology, Polish Mother\u2019s Memorial Hospital Research Institute, 93-338 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3469-7064","authenticated-orcid":false,"given":"Iwona","family":"Strzelecka","sequence":"additional","affiliation":[{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"},{"name":"Faculty of Public Health, Department for Fetal Malformations Diagnoses & Prevention, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Soko\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"},{"name":"Department of Obstetrics and Gynecology, Polish Mother\u2019s Memorial Hospital Research Institute, 93-338 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Kordjalik","sequence":"additional","affiliation":[{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0160-8013","authenticated-orcid":false,"given":"Maciej","family":"S\u0142odki","sequence":"additional","affiliation":[{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"},{"name":"Faculty of Health Sciences, The Masovian State University, 09-400 Plock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-2172","authenticated-orcid":false,"given":"Maria","family":"Respondek-Liberska","sequence":"additional","affiliation":[{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"},{"name":"Faculty of Public Health, Department for Fetal Malformations Diagnoses & Prevention, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hu, C., Yan, Y., Ji, F., and Zhou, H. (2021). Maternal Obesity Increases Oxidative Stress in Placenta and It Is Associated With Intestinal Microbiota. Front. Cell Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.671347"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1080\/14767058.2019.1573222","article-title":"Relation between pregestational obesity and characteristics of the placenta","volume":"33","year":"2020","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.placenta.2020.10.013","article-title":"The role of obesity and gestational diabetes on placental size and fetal oxygenation","volume":"103","author":"Bianchi","year":"2021","journal-title":"Placenta"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2481592","DOI":"10.1155\/2019\/2481592","article-title":"Maternal Diet-Induced Obesity Compromises Oxidative Stress Status and Angiogenesis in the Porcine Placenta by Upregulating Nox2 Expression","volume":"2019","author":"Hu","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_5","first-page":"44","article-title":"Effect of gestational diabetes and maternal hypertension on gross morphology of placenta","volume":"17","author":"Ashfaq","year":"2005","journal-title":"J. Ayub Med. Coll. Abbottabad."},{"key":"ref_6","first-page":"175","article-title":"Morphological and ultrasound findings in the placenta of diabetic pregnancy","volume":"59","author":"Berceanu","year":"2018","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/2193-1801-3-353","article-title":"A thick placenta: A predictor of adverse pregnancy outcomes","volume":"3","author":"Miwa","year":"2014","journal-title":"Springerplus"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0887-2171(96)90045-1","article-title":"Sonography of the placenta with emphasis on pathological correlation","volume":"17","author":"Harris","year":"1996","journal-title":"Semin. Ultrasound CT MR"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1515\/jpm-2022-0076","article-title":"Maternal urogenital infection and fetal heart functional assessment-what is the missing link?","volume":"51","author":"Murlewska","year":"2022","journal-title":"J. Perinat. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1469-0705.1991.01040241.x","article-title":"Fetal toxoplasmosis: Ultrasonographic signs","volume":"1","author":"Hohlfeld","year":"1991","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12936-015-0627-1","article-title":"Ultrasound findings in pregnant women with uncomplicated vivax malaria in the Brazilian Amazon: A cohort study","volume":"14","author":"Brock","year":"2015","journal-title":"Malar. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/15513815.2018.1485798","article-title":"Fetal and Placental Pathology in Congenital Syphilis: A Comprehensive Study in Perinatal Autopsy","volume":"37","author":"Kittipornpechdee","year":"2018","journal-title":"Fetal Pediatr. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"574","DOI":"10.5603\/GP.a2017.0103","article-title":"The course of pregnancy and delivery in a patient with malaria","volume":"88","author":"Krekora","year":"2017","journal-title":"Ginekol. Pol."},{"key":"ref_14","first-page":"e56410","article-title":"Correlation Between Ultrasonographic Placental Thickness and Adverse Fetal and Neonatal Outcomes","volume":"16","author":"Rawal","year":"2024","journal-title":"Cureus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1053\/plac.1999.0466","article-title":"Sonographically thick placenta: A marker for increased perinatal risk--a prospective cross-sectional study","volume":"21","author":"Elchalal","year":"2000","journal-title":"Placenta"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"300060521990969","DOI":"10.1177\/0300060521990969","article-title":"Insights into the role of placenta thickness as a predictive marker of perinatal outcome","volume":"49","author":"Sun","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.21037\/tp-21-297","article-title":"Genetics of congenital heart disease: A narrative review of recent advances and clinical implications","volume":"10","author":"Yasuhara","year":"2021","journal-title":"Transl. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kalisch-Smith, J.I., Ved, N., and Sparrow, D.B. (2020). Environmental Risk Factors for Congenital Heart Disease. Cold Spring Harb. Perspect. Biol., 12.","DOI":"10.1101\/cshperspect.a037234"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhang, T.N., Wu, Q.J., Liu, Y.S., Lv, J.L., Sun, H., Chang, Q., Liu, C.F., and Zhao, Y.H. (2021). Environmental Risk Factors and Congenital Heart Disease: An Umbrella Review of 165 Systematic Reviews and Meta-Analyses With More Than 120 Million Participants. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.640729"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"153.e1","DOI":"10.1016\/j.ajog.2012.11.043","article-title":"The fetal cardiovascular response to increased placental vascular impedance to flow determined with 4-dimensional ultrasound using spatiotemporal image correlation and virtual organ computer-aided analysis","volume":"208","author":"Hamill","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/pd.6572","article-title":"Interdependence of placenta and fetal cardiac development","volume":"44","author":"Leon","year":"2024","journal-title":"Prenat. Diagn."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/CS20220428","article-title":"Molecular regulators of defective placental and cardiovascular development in fetal growth restriction","volume":"138","author":"Umapathy","year":"2024","journal-title":"Clin. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Camm, E.J., Botting, K.J., and Sferruzzi-Perri, A.N. (2018). Near to One\u2019s Heart: The Intimate Relationship Between the Placenta and Fetal Heart. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.00629"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Sferruzzi-Perri, A.N., and Camm, E.J. (2016). The Programming Power of the Placenta. Front. Physiol., 7.","DOI":"10.3389\/fphys.2016.00033"},{"key":"ref_25","unstructured":"Respondek-Liberska, M. (2021). Klasyfikacja wad serca w kardiologii prenatalnej w III trymestrze i przed porodem. Wady Serca P\u0142odu, PZWL Wydawnictwo Lekarskie."},{"key":"ref_26","unstructured":"Respondek-Liberska, M. (2019). Diagnostyka prenatalna USG\/ECHO: Zmiany czynno\u015bciowe w uk\u0142adzie kr\u0105\u017cenia p\u0142odu. Cz\u0119\u015b\u0107 Szczeg\u00f3\u0142owa [Prenatal Ultrasound\/ECHO Diagnostics: Functional Changes in the Fetal Circulatory System. Detailed Part], PZWL Wydawnictwo Lekarskie."},{"key":"ref_27","unstructured":"Respondek-Liberska, M. (2016). Diagnostyka Prenatalna USG\/ECHO cz. 1: Wady Wymagaj\u0105ce Interwencji Chirurgicznej [Prenatal Ultrasound\/ECHO Diagnostics Part 1: Defects Requiring Surgical Intervention], PZWL."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chang, C.S., Hong, S.Y., Kim, S.Y., Kim, Y.M., Sung, J.H., Choi, S.J., Oh, S.Y., Roh, C.R., Song, J., and Huh, J. (2021). Prevalence of associated extracardiac anomalies in prenatally diagnosed congenital heart diseases. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0248894"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"479","DOI":"10.7863\/jum.1985.4.9.479","article-title":"Placental thickness","volume":"4","author":"Hoddick","year":"1985","journal-title":"J. Ultrasound Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/OGX.0000000000001051","article-title":"Thick Placenta in Pregnancy: A Review","volume":"77","author":"Strebeck","year":"2022","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7863\/jum.2012.31.2.213","article-title":"Placental thickness in the second trimester: A pilot study to determine the normal range","volume":"31","author":"Lee","year":"2012","journal-title":"J. Ultrasound Med."},{"key":"ref_32","first-page":"1768","article-title":"Placental thickness in 2D prenatal ultrasonographic examination","volume":"19","author":"Strzelecka","year":"2021","journal-title":"Arch. Med. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"101559","DOI":"10.1016\/j.jacadv.2024.101559","article-title":"Congenital Heart Disease Fetuses Have Decreased Mid-Gestational Placental Flow, Placental Malperfusion Defects, and Impaired Growth","volume":"4","author":"Josowitz","year":"2025","journal-title":"JACC Adv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s00246-018-1876-x","article-title":"Characterization of the Placenta in the Newborn with Congenital Heart Disease: Distinctions Based on Type of Cardiac Malformation","volume":"39","author":"Rychik","year":"2018","journal-title":"Pediatr. Cardiol."},{"key":"ref_35","first-page":"5","article-title":"Recommendation of the Polish Prenatal Cardiology Society on the Regulation of the Polish Ministry of Health concerning competencies in fetal echocardiography (code 013) and fetal cardiology (code 021)","volume":"13","author":"Murlewska","year":"2023","journal-title":"Prenat. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/uog.26224","article-title":"ISUOG Practice Guidelines (updated): Fetal cardiac screening","volume":"61","author":"Carvalho","year":"2023","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/uog.27538","article-title":"ISUOG Practice Guidelines: Performance of third-trimester obstetric ultrasound scan","volume":"63","author":"Khalil","year":"2024","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.echo.2023.04.014","article-title":"Guidelines and Recommendations for Performance of the Fetal Echocardiogram: An Update from the American Society of Echocardiography","volume":"36","author":"Donofrio","year":"2023","journal-title":"J. Am. Soc. Echocardiogr."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/21\/7461\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:52:53Z","timestamp":1761198773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/21\/7461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":38,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["jcm14217461"],"URL":"https:\/\/doi.org\/10.3390\/jcm14217461","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]}}}