{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T04:23:54Z","timestamp":1761279834027,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and Objectives: Parkinson\u2019s disease is the second most common neurodegenerative disorder after Alzheimer\u2019s disease, and its incidence increases with age, being particularly high in people over 70 years of age. For patients with this condition, medical rehabilitation can have a profound impact, helping to improve mobility, preserve functional autonomy, and enhance quality of life. Focal vibration stimulation is a promising, well-tolerated, and easy-to-apply method with potential to facilitate motor activity and support the motor learning process, making it also useful in gait reeducation for patients with various neurological conditions. This systematic review aims to analyze the existing scientific evidence on the effectiveness of focal muscle vibration therapy in managing symptoms of Parkinson\u2019s disease. Materials and Methods: This systematic review of the literature was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the protocol was registered in PROSPERO under the protocol registration number CRD420251120737. Searches were conducted in five databases (PubMed, PEDro, ScienceDirect, Cochrane Library, Web of Science). The selection criteria targeted original clinical studies, published in English between 2010 and the present, that investigated focal muscle vibration therapy in patients with Parkinson\u2019s disease and were fully available, excluding review papers, meta-analyses, books, and articles inaccessible in full text. Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) was used to assess the quality of the included studies. Results: The results of the studies were interpreted individually for each study, and the main information was synthesized in a comparative table to facilitate analysis. The final analysis included five studies that investigated the effects of focal muscle vibration in patients with Parkinson\u2019s disease. The results suggest that this form of stimulation may offer benefits for patients with gait disorders, improving balance and stability. Among the study\u2019s limitations are the small number of included articles (n = 5) and the restriction to English-language publications, which may limit the applicability of the results. Conclusions: Given the promising results, focal muscle vibration therapy could represent a useful option in the management of Parkinson\u2019s disease. Integrating this method into rehabilitation plans could bring significant functional benefits, but further studies are needed to confirm its long-term effectiveness and to establish standardized application protocols. No external funding was received for the conduct of this review.<\/jats:p>","DOI":"10.3390\/jcm14217472","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:20:44Z","timestamp":1761196844000},"page":"7472","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Potential of Focal Muscle Vibration Therapy in the Management of Parkinson\u2019s Disease: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Daniel","family":"Rafti","sequence":"first","affiliation":[{"name":"Vraja Marii Balnear Complex, Block E2, Mircea cel B\u0103tr\u00e2n Street, 900642 Constan\u021ba, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea-Bianca","family":"Uzun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Doctoral School, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"},{"name":"Department of Physical Medicine and Rehabilitation, Balneal and Rehabilitation Sanatorium of Techirghiol, Victor Climescu Street 34\u201340, Techirghiol, 906100 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"Bodeanu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Balneal and Rehabilitation Sanatorium of Techirghiol, Victor Climescu Street 34\u201340, Techirghiol, 906100 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana-Elena","family":"Stanciu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Balneal and Rehabilitation Sanatorium of Techirghiol, Victor Climescu Street 34\u201340, Techirghiol, 906100 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9043-7585","authenticated-orcid":false,"given":"Marius-Nicolae","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, University of Medicine and Pharmacy Carol Davila, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-3160","authenticated-orcid":false,"given":"Madalina-Gabriela","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Doctoral School, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"},{"name":"Department of Physical Medicine and Rehabilitation, Balneal and Rehabilitation Sanatorium of Techirghiol, Victor Climescu Street 34\u201340, Techirghiol, 906100 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1097\/MS9.0000000000001142","article-title":"Parkinson\u2019s disease updates: Addressing the pathophysiology, risk factors, genetics, diagnosis, along with the medical and surgical treatment","volume":"85","author":"Prajjwal","year":"2023","journal-title":"Ann. 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