{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:47:29Z","timestamp":1775281649068,"version":"3.50.1"},"reference-count":15,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Impella 5.5 provides a higher flow rate than smaller microaxial pumps and has been increasingly adopted for cardiogenic shock (CS). This study aimed to evaluate whether its introduction into our Shock Team program in 2023 improved outcomes compared with a historical cohort supported with other mechanical circulatory support (MCS) devices. Methods: We retrospectively analyzed patients with CS treated with MCS between 2020 and 2024 at a tertiary center. The Impella 5.5 group (n = 17) included patients managed after device implementation, either as stand-alone or sequential therapy. The historical cohort comprised 40 patients treated with ECMO, Impella CP, CentriMag, or IABP prior to 2023. Propensity score matching (age, sex, etiology, lactate, SCAI stage) generated 17 matched pairs. The primary outcome was survival at discharge, 30 days, 3 months, and 6 months. Secondary outcomes included bridging to recovery, heart transplantation (HTx), durable LVAD, and major complications. Results: Impella 5.5 was associated with higher survival at discharge (94.1% vs. 58.8%, p = 0.039), 30 days (94.1% vs. 58.8%, p = 0.039), and 3 months (94.1% vs. 58.8%, p = 0.039). At 6 months, survival remained higher (88.2% vs. 58.8%) but did not reach statistical significance in point analysis (p = 0.118). Bridging occurred more frequently with Impella 5.5 (HTx 64.7% vs. 52.9% (p = 0.464), recovery 17.6% vs. 5.9% (p = 0.292)), while LVAD implantation rates were similar (11.8% vs. 17.6%, p = 1.0). Major bleeding (17.6% vs. 47.1%, p = 0.141), stroke\/TIA (5.9% vs. 17.6%, p = 0.601), and the need for renal replacement therapy (5.9% vs. 23.5%, p = 0.335) were numerically lower with Impella 5.5. Conclusions: In this single-center, retrospective analysis, the introduction of Impella 5.5 was associated with higher short-term survival and favorable bridging metrics; estimates are imprecise due to small, heterogeneous samples. These hypothesis-generating findings warrant confirmation in larger, prospective multicenter cohorts<\/jats:p>","DOI":"10.3390\/jcm14217552","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:16:24Z","timestamp":1761729384000},"page":"7552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Introduction of Impella 5.5 in Cardiogenic Shock: A Single-Center, Retrospective Propensity Score-Matched Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0338-6482","authenticated-orcid":false,"given":"Maciej","family":"Bochenek","sequence":"first","affiliation":[{"name":"Clinical Department of Heart Transplantation and Mechanical Circulatory Support, Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-3566","authenticated-orcid":false,"given":"Mateusz","family":"Sokolski","sequence":"additional","affiliation":[{"name":"Clinical Department of Heart Transplantation and Mechanical Circulatory Support, Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1716-9374","authenticated-orcid":false,"given":"Anna","family":"K\u0119dziora","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiac Surgery, Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Barteczko-Grajek","sequence":"additional","affiliation":[{"name":"Clinical Department of Anaesthesiology and Intensive Therapy, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-4229","authenticated-orcid":false,"given":"Grzegorz","family":"Bielicki","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiac Surgery, Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinga","family":"Kosiorowska","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiac Surgery, Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Rachwalik","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiac Surgery, Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3256-552X","authenticated-orcid":false,"given":"Rafa\u0142","family":"Nowicki","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiac Surgery, Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8911-5303","authenticated-orcid":false,"given":"Micha\u0142","family":"Kosowski","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiology, Department of Cardiology, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Cielecka","sequence":"additional","affiliation":[{"name":"Clinical Department of Heart Transplantation and Mechanical Circulatory Support, Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-019X","authenticated-orcid":false,"given":"Micha\u0142","family":"Zakliczy\u0144ski","sequence":"additional","affiliation":[{"name":"Clinical Department of Heart Transplantation and Mechanical Circulatory Support, Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiktor","family":"Kuliczkowski","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiology, Department of Cardiology, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Przybylski","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1002\/ehf2.14510","article-title":"Differences between cardiogenic shock related to acute decompensated heart failure and acute myocardial infarction","volume":"10","author":"Bertaina","year":"2023","journal-title":"ESC Heart Fail."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13613-024-01260-y","article-title":"Management of cardiogenic shock: A narrative review","volume":"14","author":"Laghlam","year":"2024","journal-title":"Ann. Intensiv. Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1002\/ejhf.2263","article-title":"Impact of hospital transfer to hubs on outcomes of cardiogenic shock in the real world","volume":"23","author":"Lu","year":"2021","journal-title":"Eur. J. Heart Fail."},{"key":"ref_4","first-page":"CD007398","article-title":"Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock","volume":"2015","author":"Unverzagt","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1056\/NEJMoa2307227","article-title":"Extracorporeal life support in patients with acute myocardial infarction complicated by cardiogenic shock","volume":"389","author":"Thiele","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJMoa2312572","article-title":"Microaxial flow pump or standard care in infarct-related cardiogenic shock","volume":"390","author":"Jensen","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_7","first-page":"157","article-title":"Device profile of the Impella 5.0 and 5.5 system","volume":"19","author":"Pahuja","year":"2022","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.healun.2025.06.008","article-title":"Clinical management of the Impella 5.5 pump","volume":"44","author":"Bernhardt","year":"2025","journal-title":"J. Heart Lung Transplant."},{"key":"ref_9","first-page":"1071","article-title":"Outcomes with Impella CP in acute myocardial infarction versus heart failure cardiogenic shock: Insights from the Cardiogenic Shock Working Group","volume":"44","author":"Carnicelli","year":"2025","journal-title":"J. Heart Lung Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.healun.2025.05.017","article-title":"Outcomes of patients supported on Impella 5.5 for more than 14 days: A Cardiogenic Shock Working Group registry analysis","volume":"44","author":"Kanwar","year":"2025","journal-title":"J. Heart Lung Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.athoracsur.2025.01.039","article-title":"Best management practices on temporary mechanical circulatory support: Joint consensus report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society","volume":"120","author":"Deschamps","year":"2025","journal-title":"Ann. Thorac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.33963\/v.kp.98041","article-title":"Impella 5.5 and mitral transcatheter edge-to-edge repair as a bridge to heart transplantation in a patient with cardiogenic shock","volume":"82","author":"Przybylski","year":"2024","journal-title":"Kardiol. Pol."},{"key":"ref_13","first-page":"823","article-title":"First SHOCK-TEAM in Poland: Single hub center experience with multidisciplinary care for cardiogenic shock","volume":"83","author":"Kuliczkowski","year":"2025","journal-title":"Kardiol. Pol."},{"key":"ref_14","first-page":"16651","article-title":"Bridge to recovery with a left ventricular assist device and mitral transcatheter edge-to-edge repair in cardiogenic shock due to acute ischemic mitral insufficiency: A novel option to treat patients without surgery or heart transplant?","volume":"134","author":"Bochenek","year":"2024","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mariani, M.V., Pierucci, N., Cipollone, P., Vignaroli, W., Piro, A., Compagnucci, P., Matteucci, A., Chimenti, C., Pandozi, C., and Dello Russo, A. (2024). Mechanical Circulatory Support Systems in the Management of Ventricular Arrhythmias: A Contemporary Overview. J. Clin. Med., 13.","DOI":"10.3390\/jcm13061746"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/21\/7552\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:46:52Z","timestamp":1761731212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/21\/7552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":15,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["jcm14217552"],"URL":"https:\/\/doi.org\/10.3390\/jcm14217552","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]}}}