{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:56:11Z","timestamp":1786294571823,"version":"build-2736575974"},"reference-count":27,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: To evaluate the loss of quality of life (QoL) in patients with chronic obstructive sialadenitis (COS) using the Chronic Obstructive Sialadenitis Questionnaire (COSQ). Methods: The COSQ was administered to patients diagnosed with COS, with the diagnosis confirmed by sialendoscopy. Epidemiological data, obstructive causes and potentially obstructive entities were collected. QoL was assessed using the COSQ. Results: A total of 344 glands in 278 patients with COS were analyzed. Most patients were women (71.94%), and the main obstructive cause was stenosis (47.96%), followed by lithiasis, lack of papilla distensibility (LPD), and mucus plug. Stenosis was significantly more frequent in the parotid gland and in women, whereas lithiasis predominated in the submandibular gland and in men. The mean COSQ score was 30.55 and it was significantly higher in women (p &lt; 0.005), parotid gland (p &lt; 0.005), and in long-standing cases (p &lt; 0.05). Stenosis and LPD were the obstructive causes with the greatest impact on QoL (p &lt; 0.005), while lithiasis had the least impact. Potentially Obstructive Entities (POEs), such as eosinophilic sialodochitis, Sj\u00f6gren\u2019s syndrome, or radioiodine-induced sialadenitis, were associated with a notable loss of QoL. Likewise, patients without associated POEs presented significantly lower COSQ values (p &lt; 0.05). Conclusions: COS significantly affects QoL, particularly in women and in cases of parotid gland, stenosis, and LPD. Lithiasis has the least impact on QoL. It is important to standardize a thorough evaluation of COS using validated tools such as the COSQ, which are fundamental for understanding the disease and predicting the outcomes of therapeutic interventions.<\/jats:p>","DOI":"10.3390\/jcm14217560","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:16:24Z","timestamp":1761729384000},"page":"7560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quantifying the Impact of Chronic Obstructive Sialadenitis on Quality of Life"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-5765","authenticated-orcid":false,"given":"Alvaro","family":"S\u00e1nchez Barrueco","sequence":"first","affiliation":[{"name":"Medicine Faculty, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, 28691 Villanueva de la Ca\u00f1ada, Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, General Villalba University Hospital, M-608 Carretera, M-608, Km 41, 28400 Collado Villalba, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-1379","authenticated-orcid":false,"given":"Gonzalo","family":"D\u00edaz Tapia","sequence":"additional","affiliation":[{"name":"Medicine Faculty, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, 28691 Villanueva de la Ca\u00f1ada, Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, General Villalba University Hospital, M-608 Carretera, M-608, Km 41, 28400 Collado Villalba, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3309-187X","authenticated-orcid":false,"given":"Ignacio","family":"Alcal\u00e1 Rueda","sequence":"additional","affiliation":[{"name":"Medicine Faculty, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, 28691 Villanueva de la Ca\u00f1ada, Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, General Villalba University Hospital, M-608 Carretera, M-608, Km 41, 28400 Collado Villalba, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8481-679X","authenticated-orcid":false,"given":"William","family":"Aragon\u00e9s Sanzen-Baker","sequence":"additional","affiliation":[{"name":"Medicine Faculty, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, 28691 Villanueva de la Ca\u00f1ada, Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, General Villalba University Hospital, M-608 Carretera, M-608, Km 41, 28400 Collado Villalba, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-1993","authenticated-orcid":false,"given":"Jessica Mireya","family":"Santill\u00e1n Coello","sequence":"additional","affiliation":[{"name":"Medicine Faculty, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, 28691 Villanueva de la Ca\u00f1ada, Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"ENT and Cervicofacial Surgery Department, General Villalba University Hospital, M-608 Carretera, M-608, Km 41, 28400 Collado Villalba, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7228-8931","authenticated-orcid":false,"given":"Pilar","family":"Benavent Mar\u00edn","sequence":"additional","affiliation":[{"name":"ENT and Cervicofacial Surgery Department, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0425-989X","authenticated-orcid":false,"given":"Alberto","family":"Valent\u00edn Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Medicine Faculty, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, 28691 Villanueva de la Ca\u00f1ada, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0558-6541","authenticated-orcid":false,"given":"Ignacio","family":"Mahillo Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Unit, Health Research Institute, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2595-7058","authenticated-orcid":false,"given":"Carlos","family":"Cenjor Espa\u00f1ol","sequence":"additional","affiliation":[{"name":"ENT and Cervicofacial Surgery Department, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"Medicine Faculty, Universidad Aut\u00f3noma de Madrid, Calle Arzobispo Morcillo, 4, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1321-007X","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Villacampa Aub\u00e1","sequence":"additional","affiliation":[{"name":"ENT and Cervicofacial Surgery Department, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"Medicine Faculty, Universidad Aut\u00f3noma de Madrid, Calle Arzobispo Morcillo, 4, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.14639\/0392-100X-1221","article-title":"Outcomes of interventional sialendoscopy for obstructive salivary gland disorders: An Italian multicentre study","volume":"36","author":"Gallo","year":"2016","journal-title":"Acta Otorhinolaryngol. 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