{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:48:26Z","timestamp":1761745706176,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The primary objectives of platelet-rich plasma (PRP) therapy are to enhance the wound-healing process, reduce pain, and minimize the loss of productivity due to recovery time. Localized application of PRP, which is enriched with growth factors such as PDGF, TGF-\u03b21, IGF-1, VEGF, and FGF-2, as well as interleukins (IL-1, IL-4, IL-6, IL-10, and IL-13), has been documented to accelerate the healing process by approximately 30\u201340%. This study aimed to assess the safety and efficacy of platelet-rich plasma (PRP) in enhancing outcomes following circumcision in male children. Methods: The patients were divided into two groups: one undergoing standard circumcision and the other receiving PRP application during circumcision. Pain scores, edema level, bleeding, local infection, and safety of PRP were evaluated. Results: This study evaluated 80 male children undergoing circumcision, divided into two groups: Group CS (n = 44) underwent classical circumcision, and Group PRP (n = 36) received PRP application. Median ages were comparable (p = 0.101). Penile edema occurred less frequently in the PRP group (5.6%) compared to the CS group (18.2%) (p = 0.089), with no severe edema observed in the PRP group. Postoperative bleeding was present in 6.8% of the CS group but absent in the PRP group (p = 0.110). Other complications, such as nausea (CS: 6.8%, PRP: 5.6%, p = 0.816), vomiting (CS: 4.5%, PRP: 2.8%, p = 0.679), local infection (CS: 2.3%, PRP: 0%, p = 0.363), wound dehiscence (CS: 2.3%, PRP: 0%, p = 0.363), and skin tunnel formation (CS: 6.8%, PRP: 2.8%, p = 0.409), showed no significant differences. No cases of necrosis, chordee, rotational anomaly, or secondary phimosis were observed. Safety analysis of PRP revealed minor complications during blood draw: hypotension in one patient (2.8%) and local ecchymosis in two patients (5.6%), resolving without intervention. During PRP application, one allergic reaction (2.8%) occurred, presenting as a transient rash that resolved spontaneously. Group PRP consistently reported lower pain scores than Group CS at all time points. Conclusions: PRP application during circumcision is safe. The findings provide preliminary but important evidence regarding the potential benefits of PRP in pediatric circumcision.<\/jats:p>","DOI":"10.3390\/jcm14217620","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:16:24Z","timestamp":1761729384000},"page":"7620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Safety and Efficacy of Platelet-Rich Plasma in Enhancing Outcomes Following Circumcision in Children"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-4003","authenticated-orcid":false,"given":"Tahsin Onat","family":"Kamci","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Tatvan State Hospital, 13200 Bitlis, Turkey"},{"name":"Pediatric Surgery Stem Cell Association Study Group (PESSCA), 34510 Istanbul, Turkey"},{"name":"Department of Pediatric Surgery and Pediatric Urology, Dicle University, 21830 Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3563-1230","authenticated-orcid":false,"given":"Mustafa","family":"Azizoglu","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Stem Cell Association Study Group (PESSCA), 34510 Istanbul, Turkey"},{"name":"Department of Pediatric Surgery and Pediatric Urology, Istanbul Esenyurt Necmi Kadioglu State Hospital, 34510 Istanbul, Turkey"},{"name":"Department of Stem Cell and Tissue Engineering, Faculty of Health Sciences, Istinye University, 34010 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey","family":"Klyuev","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Stem Cell Association Study Group (PESSCA), 34510 Istanbul, Turkey"},{"name":"Department of Pediatric Surgery, AO GK MEDSI, 102151 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Hanifi","family":"Okur","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Stem Cell Association Study Group (PESSCA), 34510 Istanbul, Turkey"},{"name":"Department of Pediatric Surgery and Pediatric Urology, Dicle University, 21830 Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5879-7759","authenticated-orcid":false,"given":"Hakkari","family":"Aydogdu","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Stem Cell Association Study Group (PESSCA), 34510 Istanbul, Turkey"},{"name":"Department of Pediatric Surgery and Pediatric Urology, Dicle University, 21830 Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3256-7576","authenticated-orcid":false,"given":"Maria","family":"Escolino","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Federico II University Hospital, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli Pinar","family":"Zorba Yildiz","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Stem Cell Association Study Group (PESSCA), 34510 Istanbul, Turkey"},{"name":"Vocational School of Health Care Services, Istinye University, 34010 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Esposito","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Federico II University Hospital, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh","family":"Shehata","sequence":"additional","affiliation":[{"name":"Pediatric Surgery, Alexandria University, Alexandria 22301, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Weiss, H.A., Larke, N., Halperin, D., and Schenker, I. 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