{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:15:57Z","timestamp":1792034157560,"version":"4.4.0"},"reference-count":57,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"National Research and Development Agency of Chile","doi-asserted-by":"publisher","award":["11220035"],"award-info":[{"award-number":["11220035"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Children with cerebral palsy (CP) commonly present impairments in gross motor function and limitations in activities of daily living (ADLs), which negatively impact independence and quality of life. Identifying effective rehabilitation strategies is essential to promote functional development. To evaluate the effectiveness of occupational therapy (OT) interventions on gross motor function and independence in ADLs among children with CP. Methods: Seven electronic databases were searched through August 2025. The review protocol was registered in PROSPERO (CRD42025634706) and conducted in accordance with PRISMA guidelines. Methodological quality and certainty of evidence were assessed using the Oxford Centre for Evidence-Based Medicine scale, the Risk of Bias 2 (RoB 2) tool, and GRADEpro. Randomized controlled trials reporting OT interventions targeting gross motor and ADL outcomes were included. Results: Of 594 identified records, 14 studies met the inclusion criteria. Meta-analysis indicated that OT interventions significantly improved gross motor function (GMFM-66; ES = 0.32 [0.01\u20130.63], p = 0.04), mobility (PEDI-Mobility; ES = 0.46 [0.05\u20130.87], p = 0.02), and occupational performance (COPM-Performance; ES = 2.63 [1.14\u20134.11], p = 0.001) and satisfaction (COPM-Satisfaction; ES = 2.17 [0.82\u20133.51], p = 0.002). No significant changes were observed in self-care (PEDI-Self-Care; ES = 0.19 [\u22120.14\u20130.53], p = 0.26). Conclusions: Evidence suggests that OT interventions effectively enhance gross motor function, mobility, and occupational performance in children with CP. These results support the integration of OT within pediatric rehabilitation programs to optimize functional outcomes.<\/jats:p>","DOI":"10.3390\/jcm14217624","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:16:24Z","timestamp":1761729384000},"page":"7624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Occupational Therapy-Based Intervention on Gross Motor Function and Independence in Activities of Daily Living in Children with Cerebral Palsy: A Systematic Review with Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"given":"Diego","family":"Fernandez-Cardenas","sequence":"first","affiliation":[{"name":"School of Occupational Therapy, Health Sciences Faculty, Catholic University of Maule, Talca 3530000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-816X","authenticated-orcid":false,"given":"Celia","family":"S\u00e1nchez-Gomez","sequence":"additional","affiliation":[{"name":"Department of Developmental and Educational Psychology, University of Salamanca, 37008 Salamanca, Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-6587","authenticated-orcid":false,"given":"Edgar","family":"V\u00e1squez-Carrasco","sequence":"additional","affiliation":[{"name":"School of Occupational Therapy, Faculty of Psychology, Universidad de Talca, Talca 3465548, Chile"},{"name":"Centro de Investigaci\u00f3n en Ciencias Cognitivas, Faculty of Psychology, Universidad de Talca, Talca 3465548, Chile"},{"name":"VITALIS Longevity Center, Universidad de Talca, Talca 3465548, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Hernandez-Martinez","sequence":"additional","affiliation":[{"name":"Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile"},{"name":"G-IDyAF Research Group, Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"P\u00e9rez-C\u00e1rcamo","sequence":"additional","affiliation":[{"name":"G-IDyAF Research Group, Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3184-6482","authenticated-orcid":false,"given":"Cristian","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Escuela de Tecnolog\u00eda M\u00e9dica, Facultad de Salud, Universidad Santo Tom\u00e1s, Los Carreras 753, Osorno 5310431, Chile"},{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-8280","authenticated-orcid":false,"given":"Pablo","family":"Vald\u00e9s-Badilla","sequence":"additional","affiliation":[{"name":"Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Cat\u00f3lica del Maule, Talca 3530000, Chile"},{"name":"Sports Coach Career, Faculty of Life Sciences, Universidad de Vi\u00f1a del Mar, Vi\u00f1a del Mar 2520000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Carmine-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Carrera de Medicina, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Lorca","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-8545","authenticated-orcid":false,"given":"Eduardo","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Nursing and Physiotherapy, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref_1","first-page":"91","article-title":"Cerebral palsy: An overview","volume":"73","author":"Krigger","year":"2006","journal-title":"Am. 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