{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:40Z","timestamp":1792789660969,"version":"4.5.0"},"reference-count":109,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grunenthal Srl Italy","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Osteoarthritis (OA) is one of the most frequent orthopedic disorders and a common cause of chronic pain, which is one of the most important factors in recommending total joint arthroplasty (TJA). Due to a greater need for pain relief and improved mobility in the OA population, TJA procedures are in high demand, and most patients with OA experience long waiting times. Waiting for TJA places a significant burden on patients as a result of worsening pain and functional deterioration. Therefore, optimizing pre-operative circumstances in these patients is essential to target analgesic interventions, preserve post-operative quality of life, and minimize post-operative outcomes such as chronic post-surgical pain. Achieving optimal pain control before surgery remains an unmet need, and it is difficult to devise a one-size-fits-all analgesic regimen. Pain is a challenge for orthopedic healthcare professionals (OHCPs), and orthopedic patients are notably less satisfied than patients undergoing other surgeries in terms of pain management. We reviewed the latest clinical evidence on pain management in patients with OA wait-listed for TJA to help OHCPs effectively manage their pain. Here, we provide actionable suggestions to strengthen orthopedic surgeons\u2019 competency in pain assessment and therapy selection. By integrating the perspectives of an orthopedic surgeon and a pain therapist, we also introduce the concept of \u201cpain prehabilitation\u201d and propose integrating it into standard care protocols during the TJA wait-list period to optimize TJA outcomes and prevent the development of chronic post-surgical pain.<\/jats:p>","DOI":"10.3390\/jcm14217659","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T03:44:39Z","timestamp":1761795879000},"page":"7659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["\u201cPain Prehabilitation\u201d in Major Joint Surgery: The Way Forward to Improve Outcomes and Prevent Pain Chronicity"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7184-5519","authenticated-orcid":false,"given":"Flaminia","family":"Coluzzi","sequence":"first","affiliation":[{"name":"Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy"},{"name":"Unit Anaesthesia, Intensive Care and Pain Therapy, Sant\u2019Andrea University Hospital, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0716-4951","authenticated-orcid":false,"given":"Alberto","family":"Di Martino","sequence":"additional","affiliation":[{"name":"1st Orthopedic Department, IRCCS\u2014Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"},{"name":"Department of Biomedical and Neuromotor Sciences\u2014DIBINEM, University of Bologna, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.healthpol.2018.03.010","article-title":"Mapping existing hip and knee replacement registries in Europe","volume":"122","author":"Silman","year":"2018","journal-title":"Health Policy"},{"key":"ref_2","unstructured":"GBD 2021 Osteoarthritis Collaborators (2023). Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: A systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol., 5, e508\u2013e522."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11926-012-0279-x","article-title":"Mechanisms of chronic pain in osteoarthritis","volume":"14","author":"Schaible","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1136\/ard.2005.047811","article-title":"Indications for total hip replacement: Comparison of assessments of orthopaedic surgeons and referring physicians","volume":"65","author":"Dieppe","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bouri, F., El Ansari, W., Mahmoud, S., Elhessy, A., Al-Ansari, A., and Al-Dosari, M.A.A. (2018). Orthopedic professionals\u2019 recognition and knowledge of pain and perceived barriers to optimal pain management at five hospitals. Healthcare, 6.","DOI":"10.3390\/healthcare6030098"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"de Souza, D.N., Lorentz, A., Charalambous, L., Galetta, M., Petrilli, C., and Rozell, J.C. (2024). Comprehensive pain management in total joint arthroplasty: A review of contemporary approaches. J. Clin. Med., 13.","DOI":"10.3390\/jcm13226819"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Vitaloni, M., Botto-van Bemden, A., Sciortino, R., Carn\u00e9, X., Quintero, M., Santos-Moreno, P., Espinosa, R., Rillo, O., Monfort, J., and de Abajo, F. (2020). A patients\u2019 view of OA: The Global Osteoarthritis Patient Perception Survey (GOAPPS), a pilot study. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-03741-0"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Iolascon, G., Migliore, A., Beretta, G., Bernetti, A., Bortolotti, R., Celano, A., Giarratano, A., Marinangeli, F., Momoli, A., and Sebastiani, G.D. (2024). Pain management in knee osteoarthritis: Insights from an exploratory online survey of Italian patients and physicians. Healthcare, 12.","DOI":"10.3390\/healthcare12202077"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.joca.2021.02.138","article-title":"Understanding prescription behavior across healthcare professionals in treating knee osteoarthritis before and during the 2020 COVID-19 pandemic","volume":"29","author":"Hamdan","year":"2021","journal-title":"Osteoarthr. Cartil."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"French, H., Cunningham, J., Bennett, K., Cadogan, C.A., Clyne, B., Doyle, F., Moriarty, F., Ryan, J., Smith, S., and Passos, V.L. (2024). Patterns of pain medication usage and self-reported pain in older Irish adults with osteoarthritis: A latent class analysis of data from the Irish Longitudinal Study on Ageing. BMC Musculoskelet. Disord., 25.","DOI":"10.1186\/s12891-024-07854-8"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2455067","DOI":"10.1080\/20523211.2025.2455067","article-title":"Patterns of analgesic utilisation among people with knee osteoarthritis: A cohort study using UK primary care data","volume":"18","author":"Taqi","year":"2025","journal-title":"J. Pharm. Policy Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.2147\/CIA.S174741","article-title":"Prevalence and treatment of hip and knee osteoarthritis in people aged 60 years or older in Germany: An analysis based on health insurance claims data","volume":"13","author":"Postler","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Shinde, M., Rodriguez-Watson, C., Zhang, T.C., Carrell, D.S., Mendelsohn, A.B., Nam, Y.H., Carruth, A., Petronis, K.R., McMahill-Walraven, C.N., and Jamal-Allial, A. (2022). Patient characteristics, pain treatment patterns, and incidence of total joint replacement in a US population with osteoarthritis. BMC Musculoskelet. Disord., 23.","DOI":"10.1186\/s12891-022-05823-7"},{"key":"ref_14","first-page":"n2321","article-title":"Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: Network meta-analysis","volume":"375","author":"Pereira","year":"2021","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.maturitas.2020.12.001","article-title":"Characterization of individuals with osteoarthritis in the United States and their use of prescription and over-the-counter supplements","volume":"145","author":"Lane","year":"2021","journal-title":"Maturitas"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.joca.2024.07.010","article-title":"Frequent use of prescription NSAIDs among people with knee or hip osteoarthritis despite contraindications to or precautions with NSAIDs","volume":"32","author":"Neogi","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1213\/ANE.0000000000007299","article-title":"Variations in Current Practice and Protocols of Intraoperative Multimodal Analgesia: A Cross-Sectional Study Within a Six-Hospital US Health Care System","volume":"141","author":"Graham","year":"2024","journal-title":"Anesth. Analg."},{"key":"ref_18","first-page":"127","article-title":"Acute and chronic pain in orthopaedic and rheumatologic diseases: Mechanisms and characteristics","volume":"35","author":"Masala","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1308\/rcsann.2022.0101","article-title":"Hip arthroplasty practice across the Organisation for Economic Co-operation and Development (OECD) over the last decade","volume":"105","author":"Jennison","year":"2023","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.joca.2015.05.008","article-title":"Utilization rates of knee-arthroplasty in OECD countries","volume":"23","author":"Pabinger","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"OECD (2020). Waiting times for health services: Next in line. OECD Health Policy Studies, OECD Publishing.","DOI":"10.1787\/242e3c8c-en"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Cooper, G.M., Bayram, J.M., and Clement, N.D. (2024). The functional and psychological impact of delayed hip and knee arthroplasty: A systematic review and meta-analysis of 89,996 patients. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-58050-6"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.joca.2007.01.015","article-title":"Changes in pain, stiffness and physical function in patients with osteoarthritis waiting for hip or knee joint replacement surgery","volume":"15","author":"Kapstad","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1302\/0301-620X.101B8.BJJ-2019-0116.R1","article-title":"\u2018Worse than death\u2019 and waiting for a joint arthroplasty","volume":"101-B","author":"Scott","year":"2019","journal-title":"Bone Jt. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3928\/01477447-20151228-06","article-title":"Risk assessment for chronic pain and patient satisfaction after total knee arthroplasty","volume":"39","author":"Sakellariou","year":"2016","journal-title":"Orthopedics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1515\/sjpain-2018-0022","article-title":"Patients\u2019 pre-operative general and specific outcome expectations predict postoperative pain and function after total knee and total hip arthroplasties","volume":"18","author":"Tilbury","year":"2018","journal-title":"Scand. J. Pain"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e025091","DOI":"10.1136\/bmjopen-2018-025091","article-title":"Preoperative predictors of poor acute postoperative pain control: A systematic review and meta-analysis","volume":"9","author":"Yang","year":"2019","journal-title":"BMJ Open"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bjae.2021.11.008","article-title":"Chronic post-surgical pain e update on incidence, risk factors and preventive treatment options","volume":"22","author":"Rosenberger","year":"2022","journal-title":"BJA Educ."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lindberg, M.F., Miaskowski, C., Rustoen, T., Rosseland, L.A., Paul, S.M., and Lerdal, A. (2016). Preoperative pain, symptoms, and psychological factors related to higher acute pain trajectories during hospitalization for total knee arthroplasty. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161681"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/ALN.0b013e3181f85ed2","article-title":"Preoperative pain sensitivity and its correlation with postoperative pain and analgesic consumption: A qualitative systematic review","volume":"114","author":"Abrishami","year":"2011","journal-title":"Anesthesiology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/acr.22656","article-title":"Rest pain and movement-evoked pain as unique constructs in hip and knee replacements","volume":"68","author":"Sayers","year":"2016","journal-title":"Arthritis Care Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Desmeules, F., Dionne, C.E., Belzile, E., Bourbonnais, R., and Fr\u00e9mont, P. (2009). Waiting for total knee replacement surgery: Factors associated with pain, stiffness, function and quality of life. BMC Musculoskelet. Disord., 10.","DOI":"10.1186\/1471-2474-10-52"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1532-5415.2005.53114.x","article-title":"Postoperative pain management in elderly patients: Correlation between adherence to treatment guidelines and patient satisfaction","volume":"53","author":"Sauaia","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s10195-023-00729-z","article-title":"Italian Orthopaedic and Traumatology Society (SIOT) position statement on the non-surgical management of knee osteoarthritis","volume":"24","author":"Pesare","year":"2023","journal-title":"J. Orthop. Traumatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.semarthrit.2019.04.008","article-title":"An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)","volume":"49","author":"Honvo","year":"2019","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_36","unstructured":"American Academy of Orthopaedic Surgeons (2025, February 21). Surgical Management of Osteoarthritis of the Knee Evidence-Based Clinical Practice Guideline. Available online: https:\/\/www.aaos.org\/globalassets\/quality-and-practice-resources\/surgical-management-knee\/smoak2cpg.pdf."},{"key":"ref_37","unstructured":"American Academy of Orthopaedic Surgeons (2025, February 21). Management of Osteoarthritis of the Hip Evidence-Based Clinical Practice Guideline. Available online: https:\/\/www.aaos.org\/globalassets\/quality-and-practice-resources\/osteoarthritis-of-the-hip\/oah-cpg.pdf."},{"key":"ref_38","first-page":"90","article-title":"Hip osteoarthritis: Guidelines from the American Academy of Orthopaedic Surgeons","volume":"111","author":"Arnold","year":"2025","journal-title":"Am. Fam. Physician"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/anae.15498","article-title":"PROSPECT guideline for total hip arthroplasty: A systematic review and procedure-specific postoperative pain management recommendations","volume":"76","author":"Anger","year":"2021","journal-title":"Anaesthesia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.pain.2010.04.003","article-title":"Sensitization in patients with painful knee osteoarthritis","volume":"149","author":"Nie","year":"2010","journal-title":"Pain"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.joca.2023.03.014","article-title":"Expanding and explaining symptoms in knee osteoarthritis trajectories: Fluctuations, flares, and future directions","volume":"31","author":"Thomas","year":"2023","journal-title":"Osteoarthr. Cartil."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Johnson, A.J., Vasilopoulos, T., Booker, S.Q., Cardoso, J., Terry, E.L., Powell-Roach, K., Staud, R., Kusko, D.A., Addison, A.S., and Redden, D.T. (2021). Knee pain trajectories over 18\u2009months in non-Hispanic Black and non-Hispanic White adults with or at risk for knee osteoarthritis. BMC Musculoskelet. Disord., 22.","DOI":"10.1186\/s12891-021-04284-8"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11914-015-0291-y","article-title":"A mechanism-based approach to the management of osteoarthritis pain","volume":"13","author":"Cohen","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pain.0000000000000002","article-title":"Preoperative widespread pain sensitization and chronic pain after hip and knee replacement: A cohort analysis","volume":"156","author":"Wylde","year":"2015","journal-title":"Pain"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Guida, F., Rocco, M., Luongo, L., Persiani, P., Vulpiani, M.C., Nusca, S.M., Maione, S., and Coluzzi, F. (2022). Targeting neuroinflammation in osteoarthritis with intra-articular adelmidrol. Biomolecules, 12.","DOI":"10.3390\/biom12101453"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/acr.24008","article-title":"Comorbidities in osteoarthritis: A systematic review and meta-analysis of observational studies","volume":"72","author":"Swain","year":"2020","journal-title":"Arthritis Care Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2235042X20920456","DOI":"10.1177\/2235042X20920456","article-title":"Comorbidities and their link with individual health status: A cross-sectional analysis of 23,892 people with knee and hip osteoarthritis from primary care","volume":"10","author":"Muckelt","year":"2020","journal-title":"J. Comorb."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s40266-024-01108-x","article-title":"Patterns of comorbidities and prescribing and dispensing of non-steroidal anti-inflammatory drugs (NSAIDs) among patients with osteoarthritis in the USA: Real-world study","volume":"41","author":"Ide","year":"2024","journal-title":"Drugs Aging"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/acr.23884","article-title":"Duration of symptom relief and early trajectory of adverse events for oral nonsteroidal antiinflammatory drugs in knee osteoarthritis: A systematic review and meta-analysis","volume":"72","author":"Osani","year":"2020","journal-title":"Arthritis Care Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Salis, Z., and Sainsbury, A. (2024). Association of long-term use of non-steroidal anti-inflammatory drugs with knee osteoarthritis: A prospective multi-cohort study over 4-to-5 years. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-56665-3"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s40265-018-0980-9","article-title":"Assessing and treating chronic pain in patients with end-stage renal disease","volume":"78","author":"Coluzzi","year":"2018","journal-title":"Drugs"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.arth.2024.10.041","article-title":"What are the absolute contraindications for elective total knee or hip arthroplasty?","volume":"40","author":"Choe","year":"2025","journal-title":"J. Arthroplast."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Postler, A., Goronzy, J., G\u00fcnther, K.P., Lange, T., Redeker, I., Schmitt, J., Zink, A., and Calhoff, J. (2020). Which disease-related factors influence patients\u2019 and physicians\u2019 willingness to consider joint replacement in hip and knee OA? Results of a questionnaire survey linked to claims data. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-03368-1"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Jourdan, C., Poiraudeau, S., Descamps, S., Nizard, R., Hamadouche, M., Anract, P., Boisgard, S., Galvin, M., and Ravaud, P. (2012). Comparison of patient and surgeon expectations of total hip arthroplasty. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030195"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/acr.24486","article-title":"Willingness to undergo joint surgery following a first-line intervention for osteoarthritis: Data from the Better Management of People with Osteoarthritis Register","volume":"73","author":"Rolfson","year":"2021","journal-title":"Arthritis Care Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.joca.2012.05.008","article-title":"Osteoarthritis patients\u2019 perceptions of \u201cappropriateness\u201d for total joint replacement surgery","volume":"20","author":"Frankel","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Alami, S., Boutron, I., Desjeux, D., Hirschhorn, M., Meric, G., Rannou, F., and Poiraudeau, S. (2011). Patients\u2019 and practitioners\u2019 views of knee osteoarthritis and its management: A qualitative interview study. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019634"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Carmona-Ter\u00e9s, V., Moix-Queralt\u00f3, J., Pujol-Ribera, E., Lumillo-Guti\u00e9rrez, I., Mas, X., Batlle-Gualda, E., Gobbo-Montoya, M., Jodar-Fern\u00e1ndez, L., and Berenguera, A. (2017). Understanding knee osteoarthritis from the patients\u2019 perspective: A qualitative study. BMC Musculoskelet. Disord., 18.","DOI":"10.1186\/s12891-017-1584-3"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00402-024-05681-z","article-title":"Presurgical anxiety and acute postsurgical pain predict worse chronic pain profiles after total knee\/hip arthroplasty","volume":"145","author":"Paredes","year":"2025","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1007\/s11845-024-03817-z","article-title":"Incidence and risk factors for chronic pain following primary total knee arthroplasty in an Irish surgical population","volume":"193","author":"Woodhouse","year":"2024","journal-title":"Ir. J. Med. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7885","DOI":"10.2147\/IJGM.S337170","article-title":"Predictors of chronic postsurgical pain in elderly patients undergoing hip arthroplasty: A multi-center retrospective cohort study","volume":"14","author":"Lu","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"de Ladoucette, A. (2023). Management of perioperative pain after TKA. Orthop. Traumatol. Surg. Res., 109.","DOI":"10.1016\/j.otsr.2022.103443"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","article-title":"Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)","volume":"21","author":"Berenbaum","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/AJP.0b013e3181b43d4f","article-title":"Correlates of pain intensity in men and women with hip and knee osteoarthritis. Results of a national survey: The French ARTHRIX study","volume":"25","author":"Perrot","year":"2009","journal-title":"Clin. J. Pain"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Sciacchitano, S., Carola, V., Nicolais, G., Sciacchitano, S., Napoli, C., Mancini, R., Rocco, M., and Coluzzi, F. (2024). To be frail or not to be frail: This is the question-a critical narrative review of frailty. J. Clin. Med., 13.","DOI":"10.3390\/jcm13030721"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.arth.2020.12.002","article-title":"Hospital frailty risk score outperforms current risk stratification models in primary total hip and knee arthroplasty","volume":"36","author":"Meyer","year":"2021","journal-title":"J. Arthroplast."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1136\/rapm-2018-100247","article-title":"Preoperative frailty and its association with postsurgical pain in an older patient cohort","volume":"44","author":"Esses","year":"2019","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00264-022-05657-x","article-title":"Association between frailty and clinical post-operative outcomes in patients following hip arthroplasty: A systematic review and meta-analysis","volume":"47","author":"Wen","year":"2023","journal-title":"Int. Orthop."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s40520-020-01667-0","article-title":"Frailty prevalence according to the Survey of Health, Ageing and Retirement in Europe-Frailty Instrument (SHARE-FI) definition, and its variables associated, in patients with symptomatic knee osteoarthritis: Findings from a cross-sectional study","volume":"33","author":"Salaffi","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S259","DOI":"10.1016\/j.arth.2017.04.031","article-title":"How do preoperative medications influence outcomes after total joint arthroplasty?","volume":"32","author":"Zarling","year":"2017","journal-title":"J. Arthroplast."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.bja.2023.02.039","article-title":"Current practice in the perioperative management of patients with diabetes mellitus: A narrative review","volume":"131","author":"Crowley","year":"2023","journal-title":"Br. J. Anaesth."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4244\/EIJV10I1A8","article-title":"Perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and non-cardiac surgery: A consensus document from Italian cardiological, surgical and anaesthesiological societies","volume":"10","author":"Rossini","year":"2014","journal-title":"EuroIntervention"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s40140-021-00511-z","article-title":"Perioperative Guidelines on Antiplatelet and Anticoagulant Agents: 2022 Update","volume":"12","author":"Moster","year":"2022","journal-title":"Curr. Anesthesiol. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/jama.2024.12708","article-title":"Perioperative management of patients taking direct oral anticoagulants: A review","volume":"332","author":"Douketis","year":"2024","journal-title":"JAMA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0883-5403(93)90007-Q","article-title":"Nonsteroidal anti-inflammatory drugs, perioperative blood loss, and transfusion requirements in elective hip arthroplasty","volume":"8","author":"Robinson","year":"1993","journal-title":"J. Arthroplast."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1016\/j.arth.2017.10.060","article-title":"Trends in opioid utilization before and after total knee arthroplasty","volume":"33","author":"Politzer","year":"2018","journal-title":"J. Arthroplast."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1016\/j.arth.2018.05.027","article-title":"Preoperative opioids increase the risk of periprosthetic joint infection after total joint arthroplasty","volume":"33","author":"Bell","year":"2018","journal-title":"J. Arthroplast."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2106\/JBJS.17.01414","article-title":"Preoperative opioid use is associated with higher readmission and revision rates in total knee and total hip arthroplasty","volume":"100","author":"Weick","year":"2018","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2147\/TCRM.S141332","article-title":"The challenge of perioperative pain management in opioid-tolerant patients","volume":"13","author":"Coluzzi","year":"2017","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Ravi, B., Pincus, D., Croxford, R., Leroux, T., Paterson, J., Hawker, G., and Redelmeier, D.A. (2021). Patterns of pre-operative opioid use affect the risk for complications after total joint replacement. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-01179-5"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/17453674.2019.1683790","article-title":"Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS\u00ae) Society recommendations","volume":"91","author":"Wainwright","year":"2020","journal-title":"Acta Orthop."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bja.2024.02.035","article-title":"Towards a common definition of surgical prehabilitation: A scoping review of randomised trials","volume":"133","author":"Burgess","year":"2024","journal-title":"Br. J. Anaesth."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrrheum.2013.138","article-title":"Towards a mechanism-based approach to pain management in osteoarthritis","volume":"9","author":"Malfait","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_84","first-page":"79","article-title":"The role of centralised pain in osteoarthritis","volume":"35","author":"Clauw","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"441","DOI":"10.7326\/0003-4819-140-8-200404200-00010","article-title":"Pain: Moving from symptom control toward mechanism-specific pharmacologic management","volume":"140","author":"Woolf","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"ref_86","first-page":"1672","article-title":"From acute to chronic pain: Tapentadol in the progressive stages of this disease entity","volume":"21","author":"Coluzzi","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.2147\/JPR.S190161","article-title":"Tapentadol in the treatment of osteoarthritis: Pharmacological rationale and clinical evidence","volume":"12","author":"Rinonapoli","year":"2019","journal-title":"J. Pain Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/14656566.2021.1970135","article-title":"Pharmacologic agents directed at the treatment of pain associated with maladaptive neuronal plasticity","volume":"23","author":"Pergolizzi","year":"2022","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s40122-021-00260-1","article-title":"Management of osteoarthritis: Expert opinion on NSAIDs","volume":"10","author":"Magni","year":"2021","journal-title":"Pain Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/gerona\/glac006","article-title":"Influence of long-term nonaspirin NSAID use on risk of frailty in men \u2265 60 years: The Physicians\u2019 Health Study","volume":"77","author":"Orkaby","year":"2022","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_91","first-page":"CD011274","article-title":"Effects of peri-operative nonsteroidal anti-inflammatory drugs on post-operative kidney function for adults with normal kidney function","volume":"11","author":"Bell","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1080\/03007995.2018.1449738","article-title":"Pain chronification: What should a non-pain medicine specialist know?","volume":"34","author":"Morlion","year":"2018","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2125.2012.04317.x","article-title":"Differences between opioids: Pharmacological, experimental, clinical and economical perspectives","volume":"75","author":"Drewes","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/03007995.2022.2148459","article-title":"Appropriate use of tapentadol: Focus on the optimal tapering strategy","volume":"39","author":"Vellucci","year":"2023","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.clinthera.2009.02.009","article-title":"Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: A 10-day, phase III, randomized, double-blind, active- and placebo-controlled study","volume":"31","author":"Hartrick","year":"2009","journal-title":"Clin. Ther."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40634-019-0204-6","article-title":"Tapentadol vs oxycodone\/naloxone in the management of pain after total hip arthroplasty in the fast-track setting: An observational study","volume":"6","author":"Martorelli","year":"2019","journal-title":"J. Exper. Orthop."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s10195-024-00812-z","article-title":"For many but not for all: The bikini incision direct anterior approach for total hip arthroplasty","volume":"25","author":"Faldini","year":"2024","journal-title":"A narrative review. J. Orthop. Traumatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s10195-025-00824-3","article-title":"Do all anatomic stems perform equally at long-term survival? A regional registry-based study on 12,010 total hip arthroplasty implants according to stem length and neck modularity","volume":"26","author":"Rossomando","year":"2025","journal-title":"J. Orthop. Traumatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1302\/0301-620X.107B1.BJJ-2024-0178.R1","article-title":"Stakeholder prioritization preferences for individuals awaiting hip and knee arthroplasty","volume":"107","author":"Farrow","year":"2025","journal-title":"Bone Jt. J."},{"key":"ref_100","first-page":"190","article-title":"Pain management in presurgery, discharge and rehabilitation in joint replacement: PRE.DI.RE","volume":"71","author":"Polati","year":"2020","journal-title":"Minerva Ortop. Traumatol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1185\/03007995.2015.1072088","article-title":"A holistic approach to chronic pain management that involves all stakeholders: Change is needed","volume":"31","author":"Kress","year":"2015","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s10195-024-00786-y","article-title":"Enhancing recovery: Surgical techniques and rehabilitation strategies after direct anterior hip arthroplasty","volume":"25","author":"Keating","year":"2024","journal-title":"J. Orthop. Traumatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/clinpract13030052","article-title":"Fast Track Protocols and Early Rehabilitation after Surgery in Total Hip Arthroplasty: A Narrative Review","volume":"13","author":"Brunello","year":"2023","journal-title":"Clin. Pract."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ocl.2015.09.008","article-title":"The painful total knee arthroplasty","volume":"47","author":"McDowell","year":"2016","journal-title":"Orthop. Clin. North Am."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"11868","DOI":"10.21037\/apm-21-3041","article-title":"Development and validation of a nomogram to predict chronic postoperative pain in elderly orthopedic patients","volume":"10","author":"Liu","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/rapm-2024-105614","article-title":"Chronic postsurgical pain and transitional pain services: A narrative review highlighting European perspectives","volume":"50","author":"Moka","year":"2025","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/art.30417","article-title":"Patterns of pharmacotherapy and health care utilization and costs prior to total hip or total knee replacement in patients with osteoarthritis","volume":"63","author":"Berger","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jcot.2018.08.008","article-title":"Patient expectations and satisfaction in orthopaedic surgery: A review of the literature","volume":"10","author":"Swarup","year":"2019","journal-title":"J. Clin. Orthop. Trauma"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11420-011-9203-6","article-title":"How often are patient and surgeon recovery expectations for total joint arthroplasty aligned? Results of a pilot study","volume":"7","author":"Ghomrawi","year":"2011","journal-title":"HSS J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/21\/7659\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T05:10:43Z","timestamp":1762060243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/21\/7659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":109,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["jcm14217659"],"URL":"https:\/\/doi.org\/10.3390\/jcm14217659","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]}}}