{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:58:34Z","timestamp":1762196314052,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: This study aimed to compare two methods for measuring the foveal avascular zone (FAZ) before and after phacoemulsification: a script-based semiautomated algorithm and a machine learning (ML)-based semiautomated algorithm. Methods: Optical coherence tomography angiography (OCTA) images were obtained with a Spectralis OCTA system (Heidelberg Engineering, Germany) preoperatively and in three postoperative visits. The FAZ was measured using both methods. Results: The study analyzed 708 OCTA scans from 59 eyes. Correlation analyses showed strong agreement between the semiautomated script-based and ML-based methods in the three plexuses, with Pearson correlation coefficients of r = 0.836 (95% CI: 0.74\u20130.89), r = 0.646 (95% CI: 0.45\u20130.78), and r = 0.861 (95% CI: 0.78\u20130.92), respectively (p &lt; 0.0001 for all). In longitudinal analysis, the FAZ in the SVP decreased significantly after phacoemulsification at 1 and 2 months postoperatively with both the script-based method (p = 0.017 and p = 0.039) and the ML-based method (p &lt; 0.0001 and p = 0.004). Conclusions: Our findings suggest that the ML-based approach is a reliable method for measuring the FAZ on OCTA, comparable to the semiautomated script-based algorithm, and may serve as a practical alternative. Moreover, a significant reduction in FAZ within the SVP was observed two months after phacoemulsification.<\/jats:p>","DOI":"10.3390\/jcm14217674","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T03:44:39Z","timestamp":1761795879000},"page":"7674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Automated Analysis of the Foveal Avascular Zone in Optical Coherence Tomography Angiography Before and After Phacoemulsification"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2369-7579","authenticated-orcid":false,"given":"Mar\u00eda S.","family":"Pighin","sequence":"first","affiliation":[{"name":"Institut Catal\u00e0 de Retina, 08022 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos","family":"Tsiroukis","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 de Retina, 08022 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7457-0709","authenticated-orcid":false,"given":"Agniezska","family":"Dyrda","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 de Retina, 08022 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-7880","authenticated-orcid":false,"given":"Ignasi","family":"J\u00fcrgens","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 de Retina, 08022 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"ref_1","first-page":"S1","article-title":"Angiograf\u00eda de retina por tomograf\u00eda de coherencia \u00f3ptica","volume":"9","author":"Arzabe","year":"2016","journal-title":"Oft. 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