{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T04:14:49Z","timestamp":1761797689229,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes","award":["CEI-RETRO-07-2025"],"award-info":[{"award-number":["CEI-RETRO-07-2025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Myomectomy is the preferred treatment for women with uterine fibroids who desire to preserve their fertility. This study aimed to compare perinatal outcomes between Mexican women with and without a history of myomectomy, matched in a 1:2 ratio based on maternal age and parity. Methods: A retrospective cohort study was conducted involving women with and without a history of myomectomy who received prenatal care and delivered at a tertiary care hospital in Mexico City. Women with comorbidities such as pregestational diabetes, chronic hypertension, autoimmune diseases, nephropathy, cardiomyopathy, and cancer were excluded from the study. Group 1 consisted of women with a history of myomectomy, and Group 2 included matched women without such a history. The following perinatal outcomes were evaluated: miscarriage, preterm birth, cesarean section, obstetric hemorrhage, placenta previa, surgical adhesions, and obstetric hysterectomy. Adjusted relative risk (aRR) with 95% confidence intervals (CI) was calculated. Results: A total of 122 women were analyzed in group 1, and 244 in group 2. The risk of obstetric hemorrhage aRR 7.5 (95% CI 3.9\u201311.9), surgical adhesions aRR 11.8 (5.3\u201320.7), and placenta accreta aRR 15.3 (1.3\u2013111) were significantly higher in Group 1 compared to Group 2. Other outcomes, including miscarriage, preterm birth, cesarean section, placenta previa, and obstetric hysterectomy, were similar between groups. Conclusions: Mexican pregnant women with a history of myomectomy have a higher risk of obstetric hemorrhage, surgical adhesions, and placenta accreta compared to those without such a history.<\/jats:p>","DOI":"10.3390\/jcm14217677","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T03:44:39Z","timestamp":1761795879000},"page":"7677","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perinatal Outcomes in Mexican Women with a History of Myomectomy: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-454X","authenticated-orcid":false,"given":"Fela Vanesa","family":"Morales-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Division of Education in Health Sciences, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Montes Urales 800, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn Andrea","family":"Almada-Balderrama","sequence":"additional","affiliation":[{"name":"Department of Reproductive Gynecology, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Montes Urales 800, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4740-7994","authenticated-orcid":false,"given":"Andrea Alicia","family":"Olgu\u00edn-Ortega","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Montes Urales 800, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0614-8094","authenticated-orcid":false,"given":"Pilar","family":"de Abiega-Franyutti","sequence":"additional","affiliation":[{"name":"Coordination of Gynecological and Perinatal Endocrinology, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Montes Urales 800, Mexico City 11000, Mexico"},{"name":"Science and Health Faculty, Universidad An\u00e1huac M\u00e9xico, Campus Norte, Huixquilucan 52786, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Reyes-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Coordination of Gynecological and Perinatal Endocrinology, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Montes Urales 800, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrna Souraye","family":"Godines-Enriquez","sequence":"additional","affiliation":[{"name":"Department of Reproductive Gynecology, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Montes Urales 800, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jmig.2018.01.016","article-title":"Comparison of long-term fertility outcomes after myomectomy: Relationship with number of myomas removed","volume":"25","author":"Shue","year":"2018","journal-title":"J. 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