{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:15:15Z","timestamp":1778260515319,"version":"3.51.4"},"reference-count":89,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Atrial septal defect (ASD) is characterized by an abnormal opening between the left (LA) and right atria (RA). Even though it\u2019s one of the most prevalent congenital heart defects, there are still many knowledge gaps and clinical uncertainties. This review aims to create a complex description of ASD and discuss its link with pulmonary arterial hypertension (PAH). An extensive literature search was conducted on sites such as PubMed, Google Scholar, and ScienceDirect. This study reviews the key findings of peer-reviewed articles with the keywords ASD, PAH, and congenital heart defects. The research showed that whilst there are multiple reviews, there is still a need for a deeper understanding, especially in areas of embryology, decision thresholds for closure, and pediatric-specific long-term outcomes. Current guidelines often extrapolate data only from adults or avoid certain topics. Those ambiguities often lead to variable medical practices, missed opportunities, and uncertainty for families. This review is divided into clear sections, creating a step-by-step characterization of the most important information, which can be useful to specialists. It touches on important subjects and controversies. It shows a clear timeline, starting with embryology, genetics, and anatomy, through pathophysiology and patient description, ending with recommendations and indications for specific treatment methods. Moreover, it creates a clear connection between ASD and PAH, outlining its danger and the need for prevention.<\/jats:p>","DOI":"10.3390\/jcm14217698","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:28:43Z","timestamp":1761888523000},"page":"7698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Atrial Septal Defects: From Embryology to Pediatric Pulmonary Hypertension"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-8248","authenticated-orcid":false,"given":"El\u017cbieta","family":"Bartoszewska","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroc\u0142aw, Poland"},{"name":"Students\u2019 Scientific Group of Pediatric Cardiology, 1st Department and Clinic of Pediatric, Allergology and Cardiology, Wroclaw Medical University, Cha\u0142ubi\u0144skiego 2a, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3987-8914","authenticated-orcid":false,"given":"Anna","family":"Chrapkowska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroc\u0142aw, Poland"},{"name":"Students\u2019 Scientific Group of Pediatric Cardiology, 1st Department and Clinic of Pediatric, Allergology and Cardiology, Wroclaw Medical University, Cha\u0142ubi\u0144skiego 2a, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6138-8079","authenticated-orcid":false,"given":"Oliwia","family":"Zieli\u0144ska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroc\u0142aw, Poland"},{"name":"Students\u2019 Scientific Group of Pediatric Cardiology, 1st Department and Clinic of Pediatric, Allergology and Cardiology, Wroclaw Medical University, Cha\u0142ubi\u0144skiego 2a, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3548-5458","authenticated-orcid":false,"given":"Maria","family":"Mordalska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroc\u0142aw, Poland"},{"name":"Students\u2019 Scientific Group of Pediatric Cardiology, 1st Department and Clinic of Pediatric, Allergology and Cardiology, Wroclaw Medical University, Cha\u0142ubi\u0144skiego 2a, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7689-3997","authenticated-orcid":false,"given":"Julia","family":"Lizon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroc\u0142aw, Poland"},{"name":"Students\u2019 Scientific Group of Pediatric Cardiology, 1st Department and Clinic of Pediatric, Allergology and Cardiology, Wroclaw Medical University, Cha\u0142ubi\u0144skiego 2a, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3275-5869","authenticated-orcid":false,"given":"Zuzanna","family":"Zalewska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroc\u0142aw, Poland"},{"name":"Students\u2019 Scientific Group of Pediatric Cardiology, 1st Department and Clinic of Pediatric, Allergology and Cardiology, Wroclaw Medical University, Cha\u0142ubi\u0144skiego 2a, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-5878","authenticated-orcid":false,"given":"Marek","family":"Wasicionek","sequence":"additional","affiliation":[{"name":"1st Department and Clinic of Pediatric, Allergology and Cardiology, Wroclaw Medical University, Cha\u0142ubi\u0144skiego 2a, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref_1","first-page":"e25402","article-title":"Transcatheter Occluder Devices for the Closure of Atrial Septal Defect in Children: How Safe and Effective Are They? 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