{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:22:15Z","timestamp":1761895335497,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Proximal humerus fractures are common and complex; despite advances, malunion, nonunion, and osteonecrosis remain concerns. Three-dimensional (3D) imaging\/printing has emerged to improve classification, planning, and execution, especially in displaced patterns. Methods: Multiple databases have been searched using predefined terms (\u201cproximal humerus fractures\/sequelae\u201d, \u201cthree-dimensional\u201d, and \u201c3D printing\u201d). Inclusion criteria targeted human longitudinal studies (retrospective\/prospective) on 3D-assisted fracture or sequela management; expert opinion, prior reviews, and letters to editors were excluded. Data extracted included the design, the level of evidence (LoE), the sample size, 3D application (diagnostic, planning, intraoperative, and combined), outcomes, follow-up, and complications. Results: Nineteen studies were included (fourteen fractures and five sequelae; 636 and 28 patients, respectively). In fractures, 3D imaging was used chiefly for preoperative planning (57.1%) and diagnostic support (35.7%); no intraoperative PSI was reported. In sequelae, intraoperative\/PSI dominated (100%), with planning in 80% and combined uses in 80%. Fracture studies were mostly retrospective (50.0%; LoE III 78.6%), while all sequelae were LoE IV\u2013V (60% of case reports). Standardized outcomes were reported in 42.1% of studies; follow-up was available in 42.1% (means \u2248 18 months). Complications occurred in 14.3% of fracture studies and in none of the sequelae. Conclusions: Three-dimensional printing is primarily applied for planning in fractures and intraoperative guidance in sequelae. While feasibility and potential perioperative benefits are evident, small heterogeneous cohorts and limited outcome reporting warrant larger prospective studies with standardized endpoints.<\/jats:p>","DOI":"10.3390\/jcm14217711","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:28:43Z","timestamp":1761888523000},"page":"7711","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Review of 3D Imaging and Printing in Proximal Humerus Fractures and Sequelae"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9922-6135","authenticated-orcid":false,"given":"Roberto","family":"de Giovanni","sequence":"first","affiliation":[{"name":"Department of Public Health, Naples University Hospital \u201cFederico II\u201d, Via Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Coppola","sequence":"additional","affiliation":[{"name":"Department of Public Health, Naples University Hospital \u201cFederico II\u201d, Via Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-1000","authenticated-orcid":false,"given":"Valentina","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Public Health, Naples University Hospital \u201cFederico II\u201d, Via Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-5124","authenticated-orcid":false,"given":"Massimo","family":"Mariconda","sequence":"additional","affiliation":[{"name":"Department of Public Health, Naples University Hospital \u201cFederico II\u201d, Via Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6044-5907","authenticated-orcid":false,"given":"Andrea","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Department of Public Health, Naples University Hospital \u201cFederico II\u201d, Via Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jabran, A., Peach, C., and Ren, L. (2018). Biomechanical Analysis of Plate Systems for Proximal Humerus Fractures: A Systematic Literature Review. Biomed. Eng. Online, 17.","DOI":"10.1186\/s12938-018-0479-3"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jseint.2020.10.019","article-title":"Interobserver and Intraobserver Agreement of Three-Dimensionally Printed Models for the Classification of Proximal Humeral Fractures","volume":"5","author":"Bougher","year":"2020","journal-title":"JSES Int."},{"key":"ref_3","first-page":"457","article-title":"Reverse Shoulder Arthroplasty for Two-Parts Proximal Humerus Fractures with \u201cShish-Kebab\u201d Technique","volume":"4","author":"Malfi","year":"2024","journal-title":"JSES Rev. Rep. Tech."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1007\/s00068-021-01851-5","article-title":"3D Printing-Assisted Surgery for Proximal Humerus Fractures: A Systematic Review and Meta-Analysis","volume":"48","author":"Li","year":"2022","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/17585732221150785","article-title":"Computed Tomography Improves the Diagnostic Accuracy but Not the Interobserver Reliability of the Boileau Classification of Proximal Humerus Fracture Sequelae","volume":"15","author":"Cozzolino","year":"2023","journal-title":"Shoulder Elb."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jseint.2025.01.004","article-title":"Which Is the Optimal Treatment and the Most Significant Prognostic Factor for Reverse Shoulder Arthroplasty in Case of PHAROS 2 Humeral Bone Loss? A Proportional Meta-Analysis of Non-Oncologic Patients","volume":"9","author":"Malfi","year":"2025","journal-title":"JSES Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s13018-019-1383-7","article-title":"3D Printing-Based Ganz Approach for Treatment of Femoral Head Fractures: A Prospective Analysis","volume":"14","author":"Wang","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tueni, N., and Amirouche, F. (2025). Branding a New Technological Outlook for Future Orthopaedics. Bioengineering, 12.","DOI":"10.3390\/bioengineering12050494"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Moldovan, F., Gligor, A., and B\u0103\u021bag\u0103, T. (2021). Structured Integration and Alignment Algorithm: A Tool for Personalized Surgical Treatment of Tibial Plateau Fractures. J. Pers. Med., 11.","DOI":"10.3390\/jpm11030190"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/BTH.0000000000000372","article-title":"Use of 3D Planning and Patient-Specific Guides for Proximal Humerus Corrective Osteotomy Associated With Shoulder Prosthesis Implantation in Proximal Humeral Varus Malunion","volume":"26","author":"Russo","year":"2021","journal-title":"Tech. Hand Up Extrem. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Baburaj, V., Patel, S., Kumar, V., and Dhillon, M.S. (2022). Utility of 3D Printing in the Surgical Management of Intra-Articular Distal Humerus Fractures: A Protocol for Systematic Review and Meta-Analysis. MedRxiv.","DOI":"10.1101\/2022.01.25.22269836"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40634-017-0111-7","article-title":"Prebending of Osteosynthesis Plate Using 3D Printed Models to Treat Symptomatic Os Acromiale and Acromial Fracture","volume":"4","author":"Biesmans","year":"2017","journal-title":"J. Exp. Orthop."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12891-023-06348-3","article-title":"Influence of Preoperative Simulation on the Reduction Quality and Clinical Outcomes of Open Reduction and Internal Fixation for Complex Proximal Humerus Fractures","volume":"24","author":"Wu","year":"2023","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jse.2012.01.009","article-title":"Diagnostic Accuracy of 2- and 3-Dimensional Imaging and Modeling of Distal Humerus Fractures","volume":"21","author":"Brouwer","year":"2012","journal-title":"J. Shoulder Elb. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.otsr.2016.06.009","article-title":"Application of 3D Printing Technology on the Treatment of Complex Proximal Humeral Fractures (Neer3-Part and 4-Part) in Old People","volume":"102","author":"You","year":"2016","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.2106\/JBJS.18.00477","article-title":"Computer-Assisted Virtual Surgical Technology Versus Three-Dimensional Printing Technology in Preoperative Planning for Displaced Three and Four-Part Fractures of the Proximal End of the Humerus","volume":"100","author":"Chen","year":"2018","journal-title":"J. Bone Jt. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13037-020-00258-2","article-title":"Three-Dimensional Models Increase the Interobserver Agreement for the Treatment of Proximal Humerus Fractures","volume":"14","author":"Cocco","year":"2020","journal-title":"Patient Saf. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13037-019-0195-3","article-title":"Inter-Observer Reliability of Alternative Diagnostic Methods for Proximal Humerus Fractures: A Comparison between Attending Surgeons and Orthopedic Residents in Training","volume":"13","author":"Cocco","year":"2019","journal-title":"Patient Saf. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12891-024-07202-w","article-title":"3D Printing Assisted MIPO for Treatment of Complex Middle-Proximal Humeral Shaft Fractures","volume":"25","author":"Hu","year":"2024","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Khanna, K., Brabston, E.W., Qayyum, U., Gardner, T.R., Levine, W.N., Jobin, C.M., and Ahmad, C.S. (2018). Proximal Humerus Fracture 3-D Modeling. Am. J. Orthop., 47.","DOI":"10.12788\/ajo.2018.0023"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00402-020-03676-0","article-title":"Why Locking Plates for the Proximal Humerus Do Not Fit Well","volume":"142","author":"Kim","year":"2020","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1302\/0301-620X.99B7.BJJ-2017-0014","article-title":"Prediction of the Pre-Morbid 3D Anatomy of the Proximal Humerus Based on Statistical Shape Modelling","volume":"99","author":"Poltaretskyi","year":"2017","journal-title":"Bone Jt. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5863813","DOI":"10.1155\/2022\/5863813","article-title":"3D-Printed Models versus CT Scan and X-Rays Imaging in the Diagnostic Evaluation of Proximal Humerus Fractures: A Triple-Blind Interobserver Reliability Comparison Study","volume":"2022","author":"Puglisi","year":"2022","journal-title":"Adv. Orthop."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.12659\/MSM.906355","article-title":"Assessment of Screw Length of Proximal Humerus Internal Locking System (PHILOS) Plate for Proximal Humeral Fractures Using Three-Dimensional Computed Tomography Scan","volume":"24","author":"Qiang","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1016\/j.jse.2020.02.022","article-title":"A New Classification of Impacted Proximal Humerus Fractures Based on the Morpho-Volumetric Evaluation of Humeral Head Bone Loss with a 3D Model","volume":"29","author":"Russo","year":"2020","journal-title":"J. Shoulder Elb. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/CORR.0000000000001921","article-title":"3D-Printed Handheld Models Do Not Improve Recognition of Specific Characteristics and Patterns of Three-Part and Four-Part Proximal Humerus Fractures","volume":"480","author":"Spek","year":"2021","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_27","first-page":"25","article-title":"Custom 3D Printed Jigs in Salvage Reverse Shoulder Arthroplasty for Failed Four-Part Proximal Humerus Fracture Fixation: A Case Report","volume":"10","author":"Thati","year":"2020","journal-title":"PubMed"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1016\/j.jse.2015.07.027","article-title":"Computer Algorithms for Three-Dimensional Measurement of Humeral Anatomy: Analysis of 140 Paired Humeri","volume":"25","author":"Vlachopoulos","year":"2015","journal-title":"J. Shoulder Elb. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1259255","DOI":"10.3389\/fbioe.2023.1259255","article-title":"3D-Printed Custom Implant for the Management of \u201cLocked\u201d Posterior Dislocation of the Shoulder Joint with Reverse Hill-Sachs Lesion: A Case Report","volume":"11","author":"Hu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jseint.2022.09.016","article-title":"Proximal Humerus Fracture Sequelae: Are Corrective Osteotomies Still a Taboo? The Role of Three-Dimensional Preoperative Planning and Patient-Specific Surgical Guides for Proximal Humerus Corrective Osteotomy in Combinazion with Reverse Shoulder Arthroplasty","volume":"7","author":"Cozzolino","year":"2023","journal-title":"JSES Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.rbo.2017.07.011","article-title":"Application of Three-Dimensional Prototyping in Planning the Treatment of Proximal Humerus Bone Deformities","volume":"53","author":"Mothes","year":"2018","journal-title":"Rev. Bras. Ortop. (Engl. Ed.)"},{"key":"ref_32","first-page":"e51551","article-title":"Advanced Preoperative Planning Techniques in the Management of Complex Proximal Humerus Fractures","volume":"16","author":"Yasen","year":"2024","journal-title":"Cureus"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13018-018-0908-9","article-title":"Proximal Third Humeral Shaft Fractures Fixed with Long Helical PHILOS Plates in Elderly Patients: Benefit of Pre-Contouring Plates on a 3D-Printed Model\u2014A Retrospective Study","volume":"13","author":"Wang","year":"2018","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10195-024-00754-6","article-title":"Three-Dimensional Printed Models Can Reduce Costs and Surgical Time for Complex Proximal Humeral Fractures: Preoperative Planning, Patient Satisfaction, and Improved Resident Skills","volume":"25","author":"Fidanza","year":"2024","journal-title":"J. Orthop. Traumatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s10195-025-00819-0","article-title":"Comparing the Efficacy of 3D-Printing-Assisted Surgery with Traditional Surgical Treatment of Fracture: An Umbrella Review","volume":"26","author":"Lin","year":"2025","journal-title":"J. Orthop. Traumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s40001-022-00830-9","article-title":"3D Accuracy and Clinical Outcomes of Corrective Osteotomies with Patient-Specific Instruments in Complex Upper Extremity Deformities: An Approach for Investigation and Correlation","volume":"27","author":"Weber","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Berhouet, J., Samargandi, R., Favard, L., Turbillon, C., Jacquot, A., and Gauci, M.-O. (2023). The Real Post-Operative Range of Motion Differs from the Virtual Pre-Operative Planned Range of Motion in Reverse Shoulder Arthroplasty. J. Pers. Med., 13.","DOI":"10.3390\/jpm13050765"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1038\/s41598-020-61267-w","article-title":"Diagnostic Accuracy of Intraoperative CT-Imaging in Complex Articular Fractures\u2014A Cadaveric Study","volume":"10","author":"Luxenhofer","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s42836-022-00146-3","article-title":"Funding Has No Effect on Clinical Outcomes of Total Joint Arthroplasty Emerging Technologies: A Systematic Review of Bibliometrics and Conflicts of Interest","volume":"4","author":"Via","year":"2022","journal-title":"Arthroplasty"},{"key":"ref_40","first-page":"8681","article-title":"3D Printing in Shoulder Surgery","volume":"12","author":"Campana","year":"2020","journal-title":"Orthop. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1186\/s12891-022-05581-6","article-title":"Efficacy and Safety of a 3D-Printed Arthrodesis Prosthesis for Reconstruction after Resection of the Proximal Humerus: Preliminary Outcomes with a Minimum 2-Year Follow-Up","volume":"23","author":"Liang","year":"2022","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Italia, K., Launay, M., Gilliland, L., Nielsen, J., Parey\u00f3n, R., Hollman, F., Salhi, A., Maharaj, J., Jomaa, M., and Cutbush, K. (2022). Single-Stage Revision Reverse Shoulder Arthroplasty: Preoperative Planning, Surgical Technique, and Mixed Reality Execution. J. Clin. Med., 11.","DOI":"10.3390\/jcm11247422"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11701-025-02485-0","article-title":"The Rise of Robotics and AI-Assisted Surgery in Modern Healthcare","volume":"19","author":"Wah","year":"2025","journal-title":"J. Robot. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Moolenaar, J.Z., T\u00fcmer, N., and Checa, S. (2022). Computer-Assisted Preoperative Planning of Bone Fracture Fixation Surgery: A State-of-the-Art Review. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.1037048"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/21\/7711\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:47:57Z","timestamp":1761889677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/21\/7711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":44,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["jcm14217711"],"URL":"https:\/\/doi.org\/10.3390\/jcm14217711","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]}}}