{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:23:17Z","timestamp":1761895397751,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"internal grant of Lublin Medical University","award":["7\/7T\/2023"],"award-info":[{"award-number":["7\/7T\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Magnetisation Transfer (MT) MRI is used for neuro-degenerative disorders, including Multiple Sclerosis (MS), providing an indirect measure of large biomolecular MR signal sources which cannot be observed directly because their typical T2 is usually much shorter than the echo time (TE) of conventional MR sequences. We investigated a 3D-radial Zero Time of Echo (ZTE) MT-weighted sequence with potentially enhanced sensitivity to short-T2 MR signals indirectly (via MT weighting) and directly (due to the short TE). Methods: The sequence runs on a human 7T MR scanner, producing whole-brain MT-weighted images with isotropic 0.8 mm resolution in 6.5 minutes. One RF pulse is used to suppress the fat signal and generate MT weighting, reducing RF power deposition to moderate levels. The small excitation pulses and the \u201cquasi-adiabatic\u201d MT pulse mitigate the negative effects of inhomogeneous transmit RF fields observed at 7T in the human head, facilitating the generation of uniform Magnetisation Transfer Ratio (MTR) maps. Results: Results from a biologic phantom, a healthy volunteer, and an MS patient illustrate important imaging features of the \u201cSilentMT\u201d sequence. When the MS patient images were compared with Fluid Attenuated Inversion Recovery (FLAIR) images taken on the same patient at 1.5T and 7T, SilentMT was able to detect all the MS lesions observed on the \u201creference truth\u201d 1.5T FLAIR; 7T FLAIR, however, failed to detect some lesions in the temporal lobe and brain stem. SilentMT detected a lesion which was not immediately apparent on either FLAIR image. Increased MTR was observed in some regions of the brain of the MS patient, notably the left temporal lobe. Conclusions: This initial investigation of an MT-weighted ZTE sequence shows evidence that it may be more sensitive to pathology in a patient with MS.<\/jats:p>","DOI":"10.3390\/jcm14217722","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:28:43Z","timestamp":1761888523000},"page":"7722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetisation Transfer 3D-Radial Zero Echo Time MR Imaging at 7T"],"prefix":"10.3390","volume":"14","author":[{"given":"Mark","family":"Symms","sequence":"first","affiliation":[{"name":"Independent Researcher, Gerrards Cross, Buckinghamshire SL9 0RJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Kozio\u0142","sequence":"additional","affiliation":[{"name":"Department of Radiography, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Rua","sequence":"additional","affiliation":[{"name":"Antaros Medical, 43183 M\u00f6lndal, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stanford School of Medicine, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4940-5558","authenticated-orcid":false,"given":"Natalia","family":"Pietro\u0144","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, University Hospital No1 in Lublin, 20-400 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Wi\u015bniewska","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, University Hospital No1 in Lublin, 20-400 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-2945","authenticated-orcid":false,"given":"Anna","family":"Niedzia\u0142ek","sequence":"additional","affiliation":[{"name":"Department of Radiography, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jamroz-Wi\u015bniewska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Stepniewski","sequence":"additional","affiliation":[{"name":"ECOTECH-COMPLEX, Maria Curie-Sk\u0142odowska University in Lublin, 20-031 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rados\u0142aw","family":"Pietura","sequence":"additional","affiliation":[{"name":"Department of Radiography, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/jnnp.49.2.113","article-title":"The mystery of the origin of multiple sclerosis","volume":"49","author":"McDonald","year":"1986","journal-title":"Neurosurg. 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