{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:24:15Z","timestamp":1781925855583,"version":"3.54.5"},"reference-count":17,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Margarete Ammon Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: There is a lack of population-based and real-world data on sex and age differences in gastric cancer care. The aim of this study was to close this data gap and to analyze the sex and age differences in the clinicopathological characteristics of gastric adenocarcinoma. Methods: The analysis focused on patients diagnosed with gastric adenocarcinomas (ICD-10: C16.0\u2013C16.9) documented in the cancer registry of the Federal State of Brandenburg from 2000 to 2020. The patient variables include sex, age at time of tumor diagnosis and the ECOG performance status. The tumor variables included location, grading, clinical TNM classification, clinical UICC stage and synchronous distant metastasis. Results: Of n = 8582 patients, 38% (n = 3263) were women. Compared with males, females had fewer adenocarcinomas located in the cardia (24.1% vs. 12.5%, p &lt; 0.001), more signet ring cell carcinomas (13.2% vs. 22.8%, p &lt; 0.001), more high-grade tumors (55.4% vs. 63.1%, p &lt; 0.001) and a higher tumor cUICC stage (cUICC IV: 44.9% vs. 48.4%, p = 0.001). There was an interaction between sex and age modulating the differences between males and females. Conclusions: We were able to demonstrate several relevant prognostic differences in gastric cancer between men and women in terms of tumor location, stage, and metastases in a large patient cohort.<\/jats:p>","DOI":"10.3390\/jcm14227894","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T11:41:47Z","timestamp":1762515707000},"page":"7894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex and Age Differences in Clinicopathological Characteristics of Gastric Cancer"],"prefix":"10.3390","volume":"14","author":[{"given":"Claus","family":"Schildberg","sequence":"first","affiliation":[{"name":"Department of General and Viszeral Surgery, Brandenburg Medical School Theodor Fontane, University Hospital Brandenburg, 14770 Brandenburg, Germany"},{"name":"Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, 16816 Neuruppin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of General and Viszeral Surgery, Brandenburg Medical School Theodor Fontane, University Hospital Brandenburg, 14770 Brandenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of General and Viszeral Surgery, Brandenburg Medical School Theodor Fontane, University Hospital Brandenburg, 14770 Brandenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Seeland","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section Sex- and Gender-Sensitive Medicine and Prevention, Otto-von-Guericke University Magdeburg, 39106 Magdeburg, Germany"},{"name":"German Society of Gender-Specific Medicine, 14467 Potsdam, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Mantke","sequence":"additional","affiliation":[{"name":"Department of General and Viszeral Surgery, Brandenburg Medical School Theodor Fontane, University Hospital Brandenburg, 14770 Brandenburg, Germany"},{"name":"Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, 16816 Neuruppin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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