{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:49:38Z","timestamp":1776106178164,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Although patients with breast cancer often undergo multiple oncologic procedures after primary tumor resection, an optimal postoperative analgesic strategy remains undefined. We evaluated the efficacy of acetaminophen\/ibuprofen as an adjunct to opioid-based patient-controlled analgesia (PCA) following oncoplastic breast surgery. Methods: In this double-blind randomized controlled trial, 79 patients were assigned to receive either acetaminophen\/ibuprofen or saline. A 100 mL solution containing 1000 mg acetaminophen and 300 mg ibuprofen was administered at the end of surgery, and 200 mL was incorporated into a fentanyl-based PCA for infusion over 48 h. The control group received an equivalent volume of saline. The primary outcome was pain intensity at 1 h postoperatively, assessed using an 11-point numerical rating scale. Secondary outcomes included pain scores at 6, 24, and 48 h, cumulative fentanyl consumption via PCA, additional analgesic use, and adverse effects. Results: Pain scores at 1 h postoperatively were significantly lower in the intervention group than in the control group (median [IQR], 2 [2, 2] vs. 2 [2, 3], p = 0.040). Cumulative fentanyl volume administered via PCA was lower in the intervention group at 24 h (252.4 [186.7, 289.9] mcg vs. 299.7 [208.3, 366.6] mcg, p &lt; 0.001) and 48 h (482.4 [283.2, 548.0] mcg vs. 537.0 [390.9, 586.0] mcg, p = 0.001). Fewer patients in the intervention group required rescue analgesics during the first 6 h (22 [56.4%] vs. 32 [80.0%], p = 0.024). Pain scores and rescue analgesic use thereafter did not differ between groups. Conclusions: Adjunctive acetaminophen\/ibuprofen with opioid-based PCA reduced early postoperative pain, opioid consumption, and rescue analgesia without increasing adverse effects.<\/jats:p>","DOI":"10.3390\/jcm14227901","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:55:15Z","timestamp":1762527315000},"page":"7901","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analgesic Efficacy of Acetaminophen\/Ibuprofen as an Adjuvant in Patient-Controlled Analgesia for Postoperative Pain After Oncoplastic Breast Surgery: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1398-3304","authenticated-orcid":false,"given":"Jin Ha","family":"Park","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-3139","authenticated-orcid":false,"given":"Dong Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-4188","authenticated-orcid":false,"given":"Jin Sun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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